Ethanol Extract of <i>Blighia sapida</i> Stem Bark Show Remarkable Prophylactic Activity in Experimental <i>Plasmodium berghei</i>–Infected Mice

Otegbade, Olayinka O; Ojo, J. S.; Adefokun, Dolapo I; Abiodun, Olufunmilola Adunni; Thomas, Bolaji N.; Ojurongbe, Olusola

doi:10.1177/1177392817728725

Cited by 9 publications

(8 citation statements)

References 30 publications

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“…This might suggest that very low doses of LED Spirulina extract-related active molecules can affect endpoints (Vandenberg 2014 ). A similar effect was shown in other plant-based whole extracts, exhibiting the highest activity at the lowest concentration (Otegbade et al 2017 ).…”

Section: Discussionsupporting

confidence: 81%

Photosynthetically Controlled Spirulina, but Not Solar Spirulina, Inhibits TNF-α Secretion: Potential Implications for COVID-19-Related Cytokine Storm Therapy

et al. 2021

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An array of infections, including the novel coronavirus (SARS-CoV-2), trigger macrophage activation syndrome (MAS) and subsequently hypercytokinemia, commonly referred to as a cytokine storm (CS). It is postulated that CS is mainly responsible for critical COVID-19 cases, including acute respiratory distress syndrome (ARDS). Recognizing the therapeutic potential of Spirulina blue-green algae (Arthrospira platensis), in this in vitro stimulation study, LPS-activated macrophages and monocytes were treated with aqueous extracts of Spirulina, cultivated in either natural or controlled light conditions. We report that an extract of photosynthetically controlled Spirulina (LED Spirulina), at a concentration of 0.1 µg/mL, decreases macrophage and monocyte-induced TNF-α secretion levels by over 70% and 40%, respectively. We propose prompt in vivo studies in animal models and human subjects to determine the putative effectiveness of a natural, algae-based treatment for viral CS and ARDS, and explore the potential of a novel anti-TNF-α therapy. Graphical abstract

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Section: Discussionsupporting

confidence: 81%

Photosynthetically Controlled Spirulina, but Not Solar Spirulina, Inhibits TNF-α Secretion: Potential Implications for COVID-19-Related Cytokine Storm Therapy

et al. 2021

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“…Natural products, especially medicinal plants, have been used to treat malaria or manage conditions associated with it in various parts of the world [ 5 , 7 ]. We show, in this study, that S. occidentalis root extract inhibits malaria parasites growth in vitro and in mice .…”

Section: Discussionmentioning

confidence: 99%

“…There were an estimated 247 million malaria cases and 619,000 deaths globally in 2021 [ 3 ]. Although malaria control has proven to be very effective when vector control is combined with prompt treatment, drug resistance to the insecticides used in vector control and antimalarial drugs pose a significant challenge to malaria control programs [ 1 , 4 – 7 ]. Furthermore, some of the available antimalarial drugs have been linked to adverse side effects such as headache, diarrhea, nausea, pruritus, anxiety, seizures and hair discoloration.…”

Section: Introductionmentioning

confidence: 99%

Senna occidentalis (L.) Link root extract inhibits Plasmodium growth in vitro and in mice

Mogaka

Molu

Kagasi

et al. 2023

BMC Complement Med Ther

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Background Senna occidentalis (L.) Link has been used worldwide in traditional treatment of many diseases and conditions including snakebite. In Kenya, a decoction from the plant roots taken orally, is used as a cure for malaria. Several studies have demonstrated that extracts from the plant possess antiplasmodial activity, in vitro. However, the safety and curative potency of the plant root against established malaria infection is yet to be scientifically validated, in vivo. On the other hand, there are reports on variation in bioactivity of extracts obtained from this plant species, depending on the plant part used and place of origin among other factors. In this study, we demonstrated the antiplasmodial activity of Senna occidentalis roots extract in vitro, and in mice. Methods Methanol, ethyl acetate, chloroform, hexane and water extracts of S. occidentalis root were tested for in vitro antiplasmodial activity against Plasmodium falciparum, strain 3D7. Cytotoxicity of the most active solvent extracts was determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and the curative potency in Plasmodium berghei infected mice evaluated by Rane’s test. Results All of the solvent extracts tested in this study inhibited the propagation of P. falciparum, strain 3D7, in vitro, with polar extracts being more active than non-polar ones. Methanolic extracts had the highest activity (IC50 = 1.76) while hexane extract displayed the lowest activity (IC50 = 18.47). At the tested concentrations, methanolic and aqueous extracts exhibited high selectivity index against P. falciparum strain 3D7 (SI > 10) in the cytotoxicity assay. Further, the extracts significantly suppressed the propagation of P. berghei parasites (P < 0.05) in vivo and increased the survival time of the infected mice (P < 0.0001). Conclusions Senna occidentalis (L.) Link root extract inhibits the propagation of malaria parasites in vitro and in BALB/c mice.

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“…The result of this study is also supported by other studies which discovered that traditional plants have an effect as prophylactic against Plasmodium. 19,18 Several in vitro and in vivo studies had also investigated the antiplasmodial activity of the K. galanga's family. 20 The best prophylactic effect was discovered in low concentration, whereas at the high dose, the parasitemia was not lower than low and middle concentration.…”

Section: The Prophylactic Effect Of Kaempferia Galangamentioning

confidence: 99%

Prophylactic effects of Kaempferia Galanga against Plasmodium berghei: in vivo study

Lusiyana

2022

J. Teknol. Laboratorium

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Recently, medicinal plants have been the main source in treating malaria. Kaempferia galanga was investigated as an antioxidant, and anti-inflammation. In vivo study of K. galanga had been verified as antimalarial for severe malaria. The objective of this study is to investigate the chemoprophylactic effect, body composition, and blood parameters of K. galanga against Plasmodium berghei. The prophylactic effects were determined by employing K. galanga (50; 100 and 200 mg/kg) in mice infected with P. berghei. Mice were subdivided into 4 groups (control negative and 3 treatment groups). The treatment groups received K. galanga daily for 3 days before the inoculation of P. berghei. Each mice were inoculated with the infected blood containing 106 of P. berghei. Parasitemia and body weight were calculated every day until 5 days post-inoculation, and the blood parameters was monitored in day 5. The parasitemia on the fifth days after inoculation revealed a significant suppresses effect compared to control (p<0.05). The suppressed effect by doses 50 mg/kg; 100 mg/kg; 200 mg/kg and negative control were 0.83%; 1.96%; 2.82%, and 17.8% respectively. The body weight on treatment groups was normal, but the control group decreased (p<0.05). The blood parameters on treatment groups were normal compared to control group. The K. galanga possess the prophylactic effect, normal weight and blood parameters against Plasmodium berghei.

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Ethanol Extract of Blighia sapida Stem Bark Show Remarkable Prophylactic Activity in Experimental Plasmodium berghei–Infected Mice

Cited by 9 publications

References 30 publications

Photosynthetically Controlled Spirulina, but Not Solar Spirulina, Inhibits TNF-α Secretion: Potential Implications for COVID-19-Related Cytokine Storm Therapy

Photosynthetically Controlled Spirulina, but Not Solar Spirulina, Inhibits TNF-α Secretion: Potential Implications for COVID-19-Related Cytokine Storm Therapy

Senna occidentalis (L.) Link root extract inhibits Plasmodium growth in vitro and in mice

Prophylactic effects of Kaempferia Galanga against Plasmodium berghei: in vivo study

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