Ethanol Extract of Chaenomeles sinensis Inhibits the Development of Benign Prostatic Hyperplasia by Exhibiting Anti-oxidant and Anti-inflammatory Effects

Abstract

Chaenomeles sinensis is known to inhibit the development and progression of many age-related diseases, but the underlying molecular mechanisms are largely unclear. In the present study, we observed that the ethanol extract of Chaenomeles sinensis scavenged 2,2’-diphenylpicrylhydrazyl and 2,2’-azinobis diammonium radicals in vitro. The ethanol extract of Chaenomeles sinensis activated antioxidant response element-luciferase activity and induced expression of NRF2 target genes in HaCaT cells. The ethanol extract of Chaenomeles sinensis also suppressed LPS-induced expression of COX-2 and iNOS proteins, and mRNA expression of TNF-α and IL-2 in RAW264.7 cells. Finally, the ethanol extract of Chaenomeles sinensis significantly suppressed testosterone propionate-induced benign prostatic hyperplasia in mice. Together, our study provides the evidence that the ethanol extract of Chaenomeles sinensis inhibits the development of benign prostatic hyperplasia by exhibiting anti-oxidant and anti-inflammatory effects.

Chaenomeles sinensis Extract Ameliorates Ovalbumin-Induced Allergic Rhinitis by Inhibiting the IL-33/ST2 Axis and Regulating Epithelial Cell Dysfunction

“…CSE is a polyphenol-rich product. It contains anti-inflammatory and antioxidant compounds such as quercetin, kaempferol, and various flavonoids [51]. Moreover, most of the positive implications of CSE can be attributed to the presence of procyanidins and other polyphenols like rutin and baicalin/apigenin 7-glucuronide; the UPLC data suggest that CSE contains significant quantities of these bioactive compounds.…”

Novel Psychopharmacological Herbs Relieve Behavioral Abnormalities and Hippocampal Dysfunctions in an Animal Model of Post-Traumatic Stress Disorder

“…In addition, a combination of herbal medicines can yield synergistic effects and minimize side effects, resulting in enhanced benefits in the treatment of various diseases [18][19][20][21]. The medicinal herbs Chaenomeles sinensis, Glycyrrhiza uralensis, and Atractylodes macrocephala are well known for their neuroprotective, anti-inflammatory, antioxidant, and anticancer activities [22][23][24][25]. The neuroprotective effect of Chaenomeles sinensis has been studied in a murine model of trimethyltin-induced memory deficits through increased choline acetyltransferase activity and attenuated learning and memory abilities [26].…”