Ethanol Extract of<i>Cordyceps militaris</i>Grown on Germinated Soybeans Attenuates Dextran-Sodium-Sulfate- (DSS-) Induced Colitis by Suppressing the Expression of Matrix Metalloproteinases and Inflammatory Mediators

Park, Dong Ki; Park, Hye-Jin

doi:10.1155/2013/102918

Cited by 24 publications

(20 citation statements)

References 25 publications

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“…In the animal-based studies, it was stated, that isoflavone intake may diminish the secretion or overexpression of tumor necrosis factor-α[ 11 , 13 , 33 ], interleukin (IL)-1β[ 11 ], IL-6[ 12 ], IL-12p40[ 12 ], interferon-γ[ 11 , 12 ], cyclooxygenase-2[ 34 ] and inducible nitric oxide synthase[ 13 , 35 ]. In animal model, while disease activity index (including inter alia body weight loss, diarrhea, gross bleeding) of colitis was assessed, isoflavone intake was also stated to be beneficial[ 13 ]. As a result, isoflavone was indicated among natural compounds positively influencing cytokines in inflammatory bowel diseases[ 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…The first study proving the association between dietary isoflavone intake and ulcerative colitis development, indicated, that isoflavone intake may be associated with an increased risk of the disease[ 10 ]. However, a number of animal-model studies indicated, that isoflavone intake may prevent exacerbations by inhibiting the colitis[ 11 - 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Influence of dietary isoflavone intake on gastrointestinal symptoms in ulcerative colitis individuals in remission

Głąbska¹,

Guzek²,

Grudzińska³

et al. 2017

WJG

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AIMTo analyse the association between isoflavone intake and ulcerative colitis motility symptoms in individuals in remission.METHODSCross-sectional study was conducted in a group of ulcerative colitis remission individuals, in sub-groups characterised by various intestinal motility and functioning characteristics (abdominal pain, flatulence, constipations, tenesmus). Total of 56 individuals with ulcerative colitis in remission (19 males and 37 females) were recruited for the study. Assessment of diet was based on self-reported data from each patient’s dietary records taken over a period of three typical, random days (2 weekdays and 1 d of the weekend). The daily isoflavone intake (daidzein, genistein, glycitein and total isoflavones) and daily isoflavone intake per 1000 kcal of diet were assessed.RESULTSNo correlations between isoflavone intake levels and number of bowel movements per day were observed both in the case of intake and intake per 1000 kcal of diet. In the group of individuals declaring lack of abdominal pain, the higher intakes of daidzein (P = 0.0075), daidzein per 1000 kcal of diet (P = 0.0358) and total isoflavone (P = 0.0358) were stated, than in the group of individuals declaring abdominal pain. In the group of individuals declaring lack of constipations, the lower intakes of glycitein (P = 0.0213) and glycitein per 1000 kcal of diet (P = 0.0213) were stated, than in the group of individuals declaring presence of constipations. No differences were observed in isoflavone intake between groups of ulcerative colitis individuals declaring lack of flatulence and declaring presence of flatulence, as well as between groups declaring lack of tenesmus and declaring presence of tenesmus.CONCLUSIONThe moderate dietary isoflavone intake may be beneficial for individuals with ulcerative colitis in remission, however, before including it into recommendations, further prospective studies are needed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of dietary isoflavone intake on gastrointestinal symptoms in ulcerative colitis individuals in remission

Głąbska¹,

Guzek²,

Grudzińska³

et al. 2017

WJG

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“…Cordyceps militaris (CM) extracts have been shown to exert strong anti-inflammatory and anticancer activities (Cho et al, 2007) and are widely used among traditional medicines in East Asia to treat inflammatory diseases. Since CM is difficult to obtain in large amounts due to the high unit cost of production, germinated soybeans were used as culture media for CM (Park & Park, 2013)…”

Section: Effect Of Therapeutic Intervention On Mmps and Timps In Expementioning

confidence: 99%

The molecular biology of matrix metalloproteinases and tissue inhibitors of metalloproteinases in inflammatory bowel diseases

Bruyn¹,

Vandooren

Ugarte-Berzal

et al. 2016

Critical Reviews in Biochemistry and Molecular Biology

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Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are thought to be predominant proteases and protease inhibitors involved in the pathogenesis of inflammatory bowel diseases (IBD) through their ability to remodel the extracellular matrix (ECM) in response to inflammatory stimuli and by their immunomodulating effects. An imbalance between MMPs and TIMPs has been linked with acute and chronic inflammation and aberrant tissue remodeling, as seen in IBD. Moreover, recurrent phases of tissue destruction and subsequent tissue repair can cause serious complications in IBD patients such as fistulas and fibrosis. The aims of this review are (i) to summarize current literature on genetic association, mRNA, and protein expression studies with regard to MMPs and TIMPs in IBD patients and various animal models, including those with transgenic and knockout mice; (ii) to compare biochemical and molecular biological data in humans with those obtained in animal model studies and (iii) to critically evaluate and translate how this knowledge may be used in practical terms to understand better the pathophysiology and mechanisms operating in IBD and to apply this for improvement of clinical outcomes at diagnostic, prognostic and therapeutic levels.

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“…Currently, traditional treatments for UC include aminosalicylates (sulfasalazine or mesalazine) and immunosuppressants (glucocorticoids, azathioprine, and methotrexate), which can produce adverse effects when used over the long term [23]. Natural products and their derivatives have been proposed as a source for new drug research and development due to their broad spectrum of therapeutic effects and their less severe side effects [10,34].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, there is a need to search for new therapeutic options that are effective and have fewer side effects. Thus, natural products and their chemical compounds have been proposed as candidates for the development of new drugs due to their broad therapeutic spectrum, low toxicity, low occurrence of side effects, and low cost [10].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory and Antioxidant Activities of the Methanolic Extract of Cyrtocarpa procera Bark Reduces the Severity of Ulcerative Colitis in a Chemically Induced Colitis Model

Rodriguez-Canales

Martínez-Galero

Nava-Torres

et al. 2020

Mediators of Inflammation

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Cyrtocarpa procera is a plant used in traditional Mexican medicine to treat different gastrointestinal problems. Here, we investigated the effects of a C. procera methanolic extract in DSS-induced colitis mice. Ulcerative colitis (UC) was induced by administering 4% DSS in drinking water to female BALB/c mice. Compared to untreated mice with UC, the treatment group receiving the C. procera extract presented less severe UC symptoms of diarrhea, bleeding, and weight loss. Additionally, colon shortening was significantly reduced, and at the microscopic level, only minor damage was observed. Levels of proinflammatory cytokines such as TNF-α, IL-1β, and IFNγ in serum as well as the MPO activity in the colon were significantly reduced in the C. procera methanolic extract-treated group. Moreover, the extract of C. procera reduced oxidative stress during UC, preventing the deterioration of the activity of antioxidant enzymes such as SOD, CAT, and GPx. Additionally, the extract decreased lipid peroxidation damage and its final products, such as malondialdehyde (MDA). In agreement with this, in vitro assays with the C. procera extract displayed good antioxidant capacity, probably due to the presence of polyphenolic compounds, in particular the flavonoids that were identified, such as chrysin, naringenin, kaempferol, and catechin, which have been reported to have anti-inflammatory and antioxidant activities. Therefore, the improvement of UC by the C. procera methanolic extract may be related to the action mechanisms of these compounds.

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Ethanol Extract ofCordyceps militarisGrown on Germinated Soybeans Attenuates Dextran-Sodium-Sulfate- (DSS-) Induced Colitis by Suppressing the Expression of Matrix Metalloproteinases and Inflammatory Mediators

Cited by 24 publications

References 25 publications

Influence of dietary isoflavone intake on gastrointestinal symptoms in ulcerative colitis individuals in remission

Influence of dietary isoflavone intake on gastrointestinal symptoms in ulcerative colitis individuals in remission

The molecular biology of matrix metalloproteinases and tissue inhibitors of metalloproteinases in inflammatory bowel diseases

Anti-Inflammatory and Antioxidant Activities of the Methanolic Extract of Cyrtocarpa procera Bark Reduces the Severity of Ulcerative Colitis in a Chemically Induced Colitis Model

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