Ethanol Extract of <i>Cudrania tricuspidata</i> Leaf Ameliorates Hyperuricemia in Mice via Inhibition of Hepatic and Serum Xanthine Oxidase Activity

Song, Seung-Hui; Park, Dae-Hun; Bae, Min‐Suk; Choi, Chulyung; Shim, Jung‐Hyun; Yoon, Goo; Cho, Young-Chang; Oh, Deog‐Hwan; Yoon, In‐Soo; Cho, Seung‐Sik

doi:10.1155/2018/8037925

Cited by 24 publications

(13 citation statements)

References 36 publications

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“…Similar comparisons can be made with other studies like Hypouricemic effect of ethanolic extract of Aster glehni leaves (p < 0.05) 22 , soursop leaves Siegesbeckia orientalis L ( p< 0..05) 23 Chondrot T (<0.05) 24 , crudrania tricuspidata leaves (p <0.05) 25 , Davillia formosana (<0.001) 26 and Citrus unshiu fruit extract (<0.01) 27 . All these agents including our test agent Ficus carica showed dose dependant reduction in serum uric acid levels.…”

Section: Discussionsupporting

confidence: 82%

Ficus Carica Reduces Serum Uric Acid Level in Hyperuricemic Rats

Irum¹,

Khan²,

Parveen³

et al. 2022

PJMHS

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Background: Ficus carica has been broadly used as traditional medicine around the world. Less toxicity of this plant represent its possible uses as therapeutic remedy for several disorders. In folk medicine, Ficus carica fruit has been used to treat hyperuricemia and associated conditions like gout and renal stones. However, no scientific work has been done so far to observe these effects. Aim and Objective: To assess that Ficus carica (Fig fruit) extract can lessen the elevated blood levels of uric acid in hyperuricemia induced by potassium oxonate in rats. Place and Duration of Study: The study was carried out at the Pharmacology Department of Post Graduate Medical Institute, Lahore and completed in six months. Methods: Thirty-six rats were divided randomly into six groups. Group A was the negative control. Group B was the positive control and rats in this group were given potassium oxonate intraperitoneally (250 mg/kg) to induce hyperuricemia. Group C received potassium oxonate and allopurinol (5mg/kg) also. Group D, E, & F received potassium oxonate and Ficus carica in three different doses low (250mg/kg), medium (500 mg/kg), and high (750 mg/kg) respectively. In all groups, potassium oxonate was administered on days one, three and seven while test agents were administered for seven consecutive days. Sampling was done on day zero, one, three and seven. Results: In experimental animals, Ficus carica fruit extract decreased serum levels of uric acid in dose dependent manner. It reduced uric acid levels significantly (p value < 0.001) in medium and high dose extract groups as compared to hyperuricemic control group. Serum uric acid levels in medium dose group E (2.8 + 0.54) and low dose group F (2.5 + 0.31) were comparable to that of allopurinol group C (2.2 + 0.27) though this effect was observed earlier in allopurinol group C indicating quicker onset of allopurinol action. Conclusion: Fiscus carica features antihyperuricemic effects. It resulted in significant decrease in levels of uric acid in serum of the extract treated animals in doses of 500mg/kg and 750mg/kg. Keywords: Ficus carica, Hyperuricemia, Potassium oxonate, Serum uric acid (SUA), Xanthine Oxidase.

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Section: Discussionsupporting

confidence: 82%

Ficus Carica Reduces Serum Uric Acid Level in Hyperuricemic Rats

Irum¹,

Khan²,

Parveen³

et al. 2022

PJMHS

View full text Add to dashboard Cite

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“…Flavones are the most common flavonoids being contacted and investigated, such as luteolin, apigenin, and baicalein. The flavone amounts have been related to the XO inhibitory activities of some herb extracts for treating gout (Pereira, Catarino, Afonso, Silva, & Cardoso, 2018; Song et al., 2018). When the site 3 on C‐ring of flavone is substituted by hydroxyl group, it turns into flavonol.…”

Section: Flavonoidsmentioning

confidence: 99%

Advances in structures required of polyphenols for xanthine oxidase inhibition

et al. 2020

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Polyphenols have been used as natural medicaments for the management of hyperuricemia for a long history. They have been attracted many interests because of the little side effects in curing hyperuricemia, which is an important advantage over the antihyperuricemic drugs. In this review, the structure-activity relationships for polyphenols as xanthine oxidase (XO) inhibitors were discussed. It is concluded that the presence of hydroxyl groups, which influences the inhibitory effects, is closely related to whether the substitutions increase the steric hindrance or disturb the interaction of flavonoid with the catalytic site of XO, and the increased size of the molecule after glycosylation may increase the steric hindrance between flavonoid and XO, and consequently reducing the competitive inhibition behaviors. However, there is no obtained simple general rule that can comprehensively describe the effects of structural alteration on the inhibition activity because the results are varied among different subclasses of polyphenols. In addition, the inhibition mechanisms are mainly assumed as polyphenol binding to the active site of XO and hindering the entrance of xanthine or the discharge of uric acid and diffusion of O 2− radical.

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“…Dodecanoic acid showed peak (intensity %): m/z 55.10 (100%), m/z 60.10 (98.41%), m/z 73.20 (92.89%), [34]. n-Hexadecanoic acid showed peak (intensity %): m/z 73.10 (100%), m/z 60.00 (93.86%), m/z 55.20 (92.04%), m/z 57.00 (56.69%), m/z 69.20 (55.05%), while in the literature it had peak (intensity %): m/z 73 (100%), m/z 129 (30%), m/z 97 (12%), m/z 256 (12%), m/z 213 (11%) [36].…”

Section: Orthogonal Projection To the Least Square (Opls) Analysis Of...mentioning

confidence: 87%

GC-MS Based Metabolite Profiling and Antibacterial Activity of Torch Ginger (<i>Etlingera elatior</i>) Flowers Extract

et al. 2022

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Torch ginger (Etlingera elatior) flowers are well known for their antibacterial effects against Staphylococcus aureus, however, the active compounds are still unknown. The purpose of this study was to conduct GC-MS-based metabolite profiling of torch ginger flower and identify compounds correlated with its S. aureus antibacterial activity using Orthogonal Projection to Latent Structure (OPLS). Using the well diffusion method, the antibacterial activity of ethanol extract, hexane, chloroform, and ethyl acetate fractions with a concentration of 80 mg/mL were investigated. The ethyl acetate fraction inhibited S. aureus growth the most (diameter of inhibition zone, DIZ 13.00–13.20 mm), while the hexane (DIZ 9.55–10.05 mm) and chloroform (DIZ 10.00–11.00 mm) fractions had moderate inhibitory activity, but the ethanol extract had no antibacterial effect. Using OPLS analysis, the GC-MS metabolite profile of all extracts and fractions was linked with the profile of antibacterial activity. This analysis revealed that Dodecanoic acid, 5-Tetradecene, and n-Hexadecanoic acid were identified as the compounds that were significantly connected with antibacterial activity.

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Ethanol Extract of Cudrania tricuspidata Leaf Ameliorates Hyperuricemia in Mice via Inhibition of Hepatic and Serum Xanthine Oxidase Activity

Cited by 24 publications

References 36 publications

Ficus Carica Reduces Serum Uric Acid Level in Hyperuricemic Rats

Ficus Carica Reduces Serum Uric Acid Level in Hyperuricemic Rats

Advances in structures required of polyphenols for xanthine oxidase inhibition

GC-MS Based Metabolite Profiling and Antibacterial Activity of Torch Ginger (<i>Etlingera elatior</i>) Flowers Extract

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