Ethanol extract of lotus (Nelumbo nucifera) root exhibits an anti-adipogenic effect in human pre-adipocytes and anti-obesity and anti-oxidant effects in rats fed a high-fat diet

You, Jeong Soon; Lee, Yun Ju; Kim, Kyoung Soo; Kim, Sung Hoon; Chang, Kyung Ja

doi:10.1016/j.nutres.2014.01.003

Cited by 63 publications

(47 citation statements)

References 53 publications

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“…Such combination was not studied previously; therefore, the obtained results in improving the lipid spectra and antioxidant capacities are found for the first time in this research. Our conclusions are in line with others, where it was reported that watermelon, the ethanol extract of lotus root, and apple flavonols, rich in antioxidants and other bioactive components, may be a viable method to improve cardiovascular disease risk factors through reduced oxidative stress [33][34][35]. It is assumed that snails, which are a source of polyphenolic compounds and essential nonstaturated fatty acids, given to rats involving Chol diets can interact like other seafood (clams), and this effect was determined in the previous work.…”

Section: Discussionsupporting

confidence: 92%

Rapana venosa consumption improves the lipid profiles and antioxidant capacities in serum of rats fed an atherogenic diet

Leontowicz

Namieśnik

et al. 2015

Nutrition Research

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Section: Discussionsupporting

confidence: 92%

Rapana venosa consumption improves the lipid profiles and antioxidant capacities in serum of rats fed an atherogenic diet

Leontowicz

Namieśnik

et al. 2015

Nutrition Research

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“…Anti-obesity effect. In a study, ethanolic extract of N. nucifera seeds decreased body weight and serum lipid levels in a high-fat diet-induced obese rats by inhibiting adipogenic factors, such as PPAR-γ, GLUT4, and leptin (You et al, 2014b). In line with this study, kaempferol, isolated from water extract of N. nucifera leaves, reduced the expression of different adipogenic transcription factors and their target genes.…”

Section: Phytochemical Profiling Of Lotussupporting

confidence: 63%

“…Several papers reported that the mixture of N. nucifera leaf extract with other natural remedies synergistically decreased the lipid profiles and body weight in high-fat diet-induced obese animals, suggesting that N. nucifera can also be consumed as a mixed natural remedy (Du et al, 2010;. Similarly, You et al reported that ethanol extract of N. nucifera seed inhibited adipogenesis in human pre-adipocytes and decreased body weight and lipid biomarkers in high-fat diet-induced obese rats (You et al, 2014b). In addition, N. nucifera leaves have been reported to have antiobesity effects.…”

mentioning

confidence: 99%

A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development

Sharma

Gautam

Adhikari³

et al. 2016

Phytotherapy Research

143

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Nelumbo nucifera, also known as sacred lotus, has primarily been used as food throughout the Asian continent, and its medicinal values have been described in Ayurvedic and Traditional Chinese Medicine. The purpose of this study is to systematically characterize the chemical profiling and pharmacological activities of N. nucifera. Herein, we critically reviewed and analysed the phytochemical and pharmacological reports of N. nucifera. Our search for the keyword 'Nelumbo nucifera pharmacology' in all databases reported in Web of Science yielded 373 results excluding reviews and abstracts in document types. Two hundred and forty-three spectrum natural compounds from different parts of N. nucifera belonging to diverse chemical groups, including alkaloids, flavonoids, glycosides, terpenoids, steroids, fatty acids, proteins, minerals, and vitamins have been reported. In addition, distinct pharmacological activities, mainly against cancer, microbial infection, diabetes, inflammation, atherosclerosis, and obesity, have been associated with crude extracts, fractions, and isolated compounds. This review highlights potential use of neferine, liensinine, isoliensinine, and nuciferine in clinical trials. In depth, mechanism of the potential chemical entities from N. nucifera via structure activity relationship needs to be explored to guarantee the stability and safety for the clinical use. Copyright © 2016 John Wiley & Sons, Ltd.

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“…; You et al . ). Lotus seeds are regarded as a well‐known health food for protein, amino acids, vitamins, unsaturated fatty acids.…”

Section: Introductionmentioning

confidence: 97%

Chemical Deterioration of Lotus Seeds During Storage

Luo

Liu

Huang

et al. 2016

Journal of Food Quality

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Starch, protein and lipids, the major components in lotus seeds, affected taste and cooking properties of the food. The chemical compositions, gelatinization properties, crystal structure of the starch, compositions of fatty acids and soluble protein of lotus seeds, stored for 24 months, 12 months and as fresh were studied. The overall starch, protein and lipid contents in lotus seeds remained unchanged during storage, but structural changes occurred. The contents of amylose and free fatty acid increased significantly during prolonged storage, but the solubility of protein decreased dramatically. The increases of onset temperature, peak temperature and gelatinization enthalpy of lotus seed starch were also studied by a differential scanning calorimetry. Its content especially for disulfide bonds, increased from 63.24 to 95.59 μ mol/g. All changes had significant correlation with storage time and ultimately denatured the sensory quality of selected aged lotus seeds. The study could be conductive to fresh lotus seed discrimination from stale seed, and dynamic monitoring of lotus seed, by determination chemical deterioration of lotus seeds during storage. Practical Applications This study is helpful to discriminate fresh lotus seed from stale seed, and explain aging mechanism, and put forward the improvement measures of lotus seed storage conditions.

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Ethanol extract of lotus (Nelumbo nucifera) root exhibits an anti-adipogenic effect in human pre-adipocytes and anti-obesity and anti-oxidant effects in rats fed a high-fat diet

Cited by 63 publications

References 53 publications

Rapana venosa consumption improves the lipid profiles and antioxidant capacities in serum of rats fed an atherogenic diet

Rapana venosa consumption improves the lipid profiles and antioxidant capacities in serum of rats fed an atherogenic diet

A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development

Chemical Deterioration of Lotus Seeds During Storage

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