Ethanol extracts of centella asiatica leaf improves memory performance in rats after chronic stress via reducing nitric oxide and increasing Brain-Derived Neurotrophic Factor (BDNF) Concentration

Hippocampal amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid GluA1 (AMPAGluA1) receptor subunit involves in learning and memory improvement following treatment withCentella asiaticaextract in adolescent rats

“…These benefits are due to the protective effect of the phytochemicals contained in the C. asiatica plant. Extracts from C. asiatica provide antioxidant properties due to the content of triterpenoids, such as asiaticoside, madecassoside, asiatic acid, and madecassic acid, and phenolics compounds, as reported previously (Nasir et al, 2015;Orhan, 2012;Sari et al, 2014;Tripathi, Mishra, Upadhyay, Purohit, & Dubey, 2015). Yolanda et al (2015) stated that some of these active substances of C. asiatica, including asiatic acid, madecassic acid, asiaticoside, and madecassoside, may be able to penetrate the blood brain barrier.…”

“…The graph shows the mean (±SEM) of escape latency in the reversal learning test. One way ANOVA showed no significant changes between the control and treatment animals (p > 0.05) with Cronbach's alpha: 1.000 reported health benefit of this herb is its improvement of brain function, particularly related to memory and learning, as the whole plant is very useful in improving these functions (Sari et al, 2014;Sirichoat et al, 2015;Yolanda et al, 2015). These benefits are due to the protective effect of the phytochemicals contained in the C. asiatica plant.…”

“…It is a tropical plant from the Apiaceae family and is widely distributed in Southeast Asian countries, such as India, China, Sri Lanka, Malaysia, and Indonesia, as well as South Africa and Madagascar (Orhan, 2012). The major chemical constituents found in C. asiatica are triterpenoid derivatives, such as asiatic acid, madecassic acid, asiaticoside, and flavonoids (Saoji et al, 2016;Sari et al, 2014;Vasavi, Arun, & Rekha, 2016). This plant has been widely used in Ayurvedic, African, and Chinese traditional medicine (Giribabu, Srinivasarao, Swapna Rekha, Muniandy, & Salleh, 2014;Vasavi et al, 2016).…”

Centella asiaticaPrevents Increase of Hippocampal Tumor Necrosis Factor-αIndependently of Its Effect on Brain-Derived Neurotrophic Factor in Rat Model of Chronic Stress

“…Recently, we reported that C. asiatica leaf ethanolic extract (CA) prevents the decrease of hippocampal brain-derived neurotrophic factor (BDNF) concentration in hippocampus upon chronic stress [7]. Luo et al similarly reported upregulation of hippocampal BDNF in chronic stress in mice receiving asiaticocide [8].…”

“…This study aimed to investigate the effect of CA on hippocampal TNF- α , IL-10, and SIRT1 as well as their possible involvement in inducing hippocampal BDNF concentration in rat model of chronic stress. Repetitive electrical foot shock was chosen for this study because this model was previously used in the report on C. asiatica effect in preventing memory impairment and the reduction of BDNF concentration upon chronic stress in rats [7]. In this study, the hippocampal tissue was directly obtained after 28 days of repetitive electrical foot shock and CA administration.…”