Ethanol extracts of Saururus chinensis suppress ovalbumin-sensitization airway inflammation

Quan, Zhejiu; Lee, Youn Ju; Yang, Ju Hye; Lu, Yue; Liu, Ying; Lee, Yeun-Kyung; Jin, Meihua; Kim, Jong-Yeon; Choi, Joon Hyuk; Son, Jong Keun; Chang, Hyeun Wook

doi:10.1016/j.jep.2010.08.002

Cited by 26 publications

(11 citation statements)

References 40 publications

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“…Recently, Korean medicine has been the subject of increased interest for its potential in the treatment of inflammatory diseases, including atopic dermatitis and airway inflammation [16, 17, 25, 26]. The present study demonstrates that oral administration of Korean herbal mixture extract, CP001, inhibits DNCB-induced AD.…”

Section: Discussionsupporting

confidence: 55%

Oral Administration of Herbal Mixture Extract Inhibits 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in BALB/c Mice

Kim

Choi

Seo

et al. 2014

Mediators of Inflammation

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CP001 is four traditional herbal medicine mixtures with anti-inflammatory properties. In this study, we investigated the effect of oral administration of CP001 ethanol extract on the 2,4-dinitrochlorobenzene- (DNCB-) induced AD mouse models. For that purpose, we observed the effects of oral administration of CP001 on skin inflammatory cell infiltration, skin mast cells, production of serum IgE, and expression of Th2 cytokine mRNA in the AD skin lesions of DNCB treated BALB/c mice. Histological analyses demonstrated that CP001 decreased dermis and epidermis thickening as well as dermal infiltration induced by inflammatory cells. In addition, CP001 decreased mast cell infiltration in count as well as dermal infiltration induced by inflammatory cells. In the skin lesions, mRNA expression of interleukin- (IL-) 4 and IL-13 was inhibited by CP001. CP001 also reduced the production of IgE level in mouse plasma. In addition, we investigated the effect of CP001 on the inflammatory allergic reaction using human mast cells (HMC-1). In HMC-1, cytokine production and mRNA levels of IL-4, IL-13, IL-6, and IL-8 were suppressed by CP001. Taken together, our results showed that oral administration of CP001 exerts beneficial effects in AD symptoms, suggesting that CP001 might be a useful candidate for the treatment of AD.

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Section: Discussionsupporting

confidence: 55%

Oral Administration of Herbal Mixture Extract Inhibits 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in BALB/c Mice

Kim

Choi

Seo

et al. 2014

Mediators of Inflammation

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“…We found that TNF-α protein levels did not decrease in a dose-dependent manner after SCWE or DSCWE treatment compared to that in untreated control cells, suggesting that TNF-α, a potent proinflammatory cytokine with immunoregulatory activities, responded strongly at low concentrations of SCWE or DSCWE. Quan et al [28] reported that allergy-related cytokines such as IL-4 and IL-13 do not change in a dose-dependent manner following treatment with anti-allergic extract ( Saururus chinensis ethanol extract) and that IL-4 and IL-13 levels decreased significantly at a doses of 10 and 100 mg/kg S. chinensis ethanol extract with similar levels. It is possible that some types of anti-allergic extracts and anti-allergy drugs may dose-dependently decrease allergy-related cytokines levels, whereas others may not.…”

Section: Discussionmentioning

confidence: 99%

Suppressive effects ofSchizandra chinensisBaillon water extract on allergy-related cytokine generation and degranulation in IgE-antigen complex-stimulated RBL-2H3 cells

Chung

Kim

Lee³

et al. 2012

Nutr Res Pract

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Schizandra chinensis Baillon is a traditional folk medicine plant that is used to treat and prevent several inflammatory diseases and cancer in Korea, but the underlying mechanisms involved in its anti-allergic activity are not fully understood. This study was designed to investigate mechanisms of anti-allergic activity of a Schizandra chinensis Baillon water extract (SCWE) in immunoglobulin E (IgE)-antigen complex-stimulated RBL2H3 cells and to assess whether gastric and intestinal digestion affects the anti-allergic properties of SCWE. Oxidative stress is an important consequence of the allergic inflammatory response. The antioxidant activities of SCWE increased in a concentration-dependent manner. RBL-2H3 cells were sensitized with monoclonal anti-dinitrophenol (DNP) specific IgE, treated with SCWE, and challenged with the antigen DNP-human serum albumin. SCWE inhibited β-hexosaminidase release and expression of interleukin (IL)-4, IL-13, and tumor necrosis factor-alpha (TNF-α) mRNA and protein in IgE-antigen complex-stimulated RBL2H3 cells. We found that digested SCWE fully maintained its antioxidant activity and anti-allergic activity against the IgE-antigen complex-induced activation of RBL-2H3 cells. SCWE may be useful for preventing allergic diseases, such as asthma. Thus, SCWE could be used as a natural functional ingredient for allergic diseases in the food and/or pharmaceutical industries.

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“…Previously, our group reported that ethyl acetate extract of the roots of S. chinensis and isolated twelve lignans showed antiseptic activity and ethanol extract of S. chinensis suppresses ovalbuminsensitization airway inflammation [2,3]. Furthermore, we reported on the isolation and cytotoxic activity of lignans from the roots of S. chinensis including four new lignans saucerneol F (SF) (Fig.…”

Section: Introductionmentioning

confidence: 99%

Saucerneol F, a new lignan, inhibits iNOS expression via MAPKs, NF-κB and AP-1 inactivation in LPS-induced RAW264.7 cells

Suh

Kwak

et al. 2012

International Immunopharmacology

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Ethanol extracts of Saururus chinensis suppress ovalbumin-sensitization airway inflammation

Cited by 26 publications

References 40 publications

Oral Administration of Herbal Mixture Extract Inhibits 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in BALB/c Mice

Oral Administration of Herbal Mixture Extract Inhibits 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in BALB/c Mice

Suppressive effects ofSchizandra chinensisBaillon water extract on allergy-related cytokine generation and degranulation in IgE-antigen complex-stimulated RBL-2H3 cells

Saucerneol F, a new lignan, inhibits iNOS expression via MAPKs, NF-κB and AP-1 inactivation in LPS-induced RAW264.7 cells

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