Ethanol Iris tenuifolia extract reduces brain damage in a mouse model of cerebral ischaemia

Abstract

In the previous experiments, the neuroprotective role of Iris tenuifolia Pall. (IT) in the model of middle cerebral artery occlusion (MCAO) was investigated. In addition, the concentrations of the cytokines tumour necrosis factor-alpha and interleukin-6 in blood plasma were measured. It was found that IT administered 1 hr prior to MCAO or immediately after MCAO reduced infarct volume significantly. IT application 1 and 4 hr after MCAO, respectively, was without any effect on infarct volume. There were no significant changes as regards tumour necrosis factor-alpha, whereas interleukin-6 concentrations were increased in blood plasma. This is the first evidence that flavonoids from Iris tenuifolia exert protective effects in the in vivo MCAO model. Our results suggest that these flavonoids are likely to be beneficial to humans by virtue of their ability to reduce infarct volume.

Exploring the Use of Iris Species: Antioxidant Properties, Phytochemistry, Medicinal and Industrial Applications

“…Similarly, the in vivo neuroprotective potential of I. tenuifolia Pall ethanolic extract was evaluated for the first time in a middle cerebral artery occlusion model (MCAO) using C57BL/6J mice [152]. Accordingly, the applications of I. tenuifolia Pall ethanolic extract one hour before or immediately after the surgery outstandingly decreased the infarct size.…”

“…Thus, different volatile organic compounds classes have been recognized in the essential oils of this plant. These compounds belong to monoterpenes (141)(142)(143)(144)(145)(146)(147)(148)(149)(150)(151)(152)(153), sesquiterpenes , diterpenes (179,180), triterpenes (181), fatty acids (182-197), aliphatic hydrocarbons (198-205), aldehydes (207-210) and cyclohexenones (211) (Table 5). Several studies have shown that essential oil (EO) from this plant is dominated by fatty acids regardless of the species and geographical origin, with various monomers as the major compounds.…”

Comparison Analysis Based on Complete Chloroplast Genomes and Insights into Plastid Phylogenomic of Four Iris Species

“…Iris species are also used as medicinal plants. Several pharmacological studies have shown that the rhizome extracts of Iris species have anticancer, anti-inflammatory, and α-glucosidase inhibitory effects and can reduce human infarct volume [5][6][7]. Few species are used to treat throat-swelling diseases [8].…”