Ethanol‐Induced Oxygen Radical Formation and Lipid Peroxidation in Rat Brain: Effect of Chronic Alcohol Consumption

Montoliú, Carmina; Vallés, Soraya L; Renau‐Piqueras, Jaime; Guerri, Consuelo

doi:10.1046/j.1471-4159.1994.63051855.x

Cited by 252 publications

(137 citation statements)

References 35 publications

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“…Acute ethanol treatment results in an increased lipid peroxide level and a decreased glutathione level in rat brain homogenates (Uysal et al 1989). Both in vitro ethanol addition and chronic alcohol consumption have been demonstrated to lead to the enhanced formation of ROS and increased lipid peroxidation in the rat brain (Montoliu et al 1994). Higher levels of lipid peroxidation in different brain regions and also in the liver were measured after both acute and chronic ethanol administrations in rats (Calabrese et al 1996;Calabrese et al 1998).…”

Section: The Effects Of Alcohol On Cellular Physiologymentioning

confidence: 99%

Alcohol stress, membranes, and chaperones

Tóth

Vı́gh

Sántha

2014

Cell Stress and Chaperones

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Ethanol, which affects all body organs, exerts a number of cytotoxic effects, most of them independent of cell type. Ethanol treatment leads to increased membrane fluidity and to changes in membrane protein composition. It can also interact directly with membrane proteins, causing conformational changes and thereby influencing their function. The cytotoxic action may include an increased level of oxidative stress. Heat shock protein molecular chaperones are ubiquitously expressed evolutionarily conserved proteins which serve as critical regulators of cellular homeostasis. Heat shock proteins can be induced by various forms of stresses such as elevated temperature, alcohol treatment, or ischemia, and they are also upregulated in certain pathological conditions. As heat shock and ethanol stress provoke similar responses, it is likely that heat shock protein activation also has a role in the protection of membranes and other cellular components during alcohol stress.

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Section: The Effects Of Alcohol On Cellular Physiologymentioning

confidence: 99%

Alcohol stress, membranes, and chaperones

Tóth

Vı́gh

Sántha

2014

Cell Stress and Chaperones

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“…Human body has an oxidative stress defense system, which is both enzymatic (superoxide dismutase, catalase, and glutathione peroxidase) and non-enzymatic (glutathione, thiol, tocopherols, etc.) (31). The nervous tissue is more sensitive to oxidative stress than other tissues because of its low antioxidant activity (32).…”

Section: Discussionmentioning

confidence: 99%

“…In a previous study, excessive ethanol consumption increased the MDA levels of rat brain synaptosomes (9). Montoliu et al (31) showed that ethanol augments reactive oxygen species and lipid peroxidation in synaptosomes. Also, in another study, chronic ethanol consumption increased the MDA levels of rat brain synaptosomes (5).…”

Section: Discussionmentioning

confidence: 99%

In Vitro Protective Effect of Betaine on Peroxidative Injury Caused By Ethanol and Aspirin Exposure on Rat Brain Synaptosomes

Söğüt¹,

Kanbak²

2016

Erciyes Med J

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Objective: Aspirin intake of specific daily doses are advised by doctors to postmenapausal women and men above 40 years of age to prevent heart attack and even cancer in recent times. In vitro cytototoxic effects of different doses of ethanol (50 mM, 100 mM ve 200 mM) alone and together with 100 µg/mL aspirin, and possible protective role of 1 mM betaine on rat brain synaptosomes were investigated. Materials and Methods:Fifteen male Sprague Dawley rat forebrains were divided into equal pieces and pooled to form ten study groups. Synaptosomal fractions extracted from pooled rat brains were incubated with different doses of ethanol, aspirin and betaine, and malondialdehyde (MDA) levels, an important indicator of cellular damage, were measured.Results: A significant increase (p<0.05) was observed in MDA level of 200 mM ethanol group compared to control group. Different doses of ethanol (50 mM, 100 mM ve 200 mM) + aspirin exposure significantly increased (p<0.001) MDA levels compared to controls, whereas betaine administration significantly decreased (p<0.001) lipid peroxidation caused by ethanol+aspirin treatment. Conclusion:We conclude that ethanol and ethanol+aspirin administration increases lipid peroxidation in rat brain synaptosomes while betaine helps prevent this peroxidative membrane injury.

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“…The implicated mechanisms behind the neuropathy have found to link with the increased oxidative stress leading to free radical damage to the nerves. 19,20 Besides, direct effects to the human body, alcohol intoxication is also associated with the social problems, including domestic violence, traffic accidents, child neglect, abuse, absenteeism in the workplace and others. 21 The harmful use of alcohol becomes the leading risk factor for death in male ages from 15-59 due to the injuries, violence and diseases.…”

Section: Discussionmentioning

confidence: 99%

Adverse Consequences of Alcohol Consumption: A Preliminary Study

Pahade¹,

Kori²,

Singh³

et al. 2016

Toxicol Forensic Med Open J

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Alcohol is a depressant drug which slows down the activity of the central nervous system (CNS) and cause health related problems associated with various positive and negative social experiences. It has both pharmacological and toxic effects on mind and other organs of the human body. In spite of the fact that alcohol is addictive and injurious to health, more than 2 billion chronic alcoholics prevail throughout the world and the number is alarmingly increasing with the addition of new drinkers including teenagers every year. At the same time, young women are found to be more vulnerable towards the adverse consequences of alcohol consumption due to their intrinsic physical differences than men. In recent years, a drinking culture has been socially accepted among the women and it is a matter of great concern among the health scientists. Alcoholism sees as the world's highly prevalent public health problem and therefore it is a serious issue, not confined to any group, culture or country. In view of increasing incidences of alcohol consumption in India and other countries associated with health related and social problems, the present study is carried out to assess the consumption pattern of alcohol in a selected population and try to understand the ill-effects of this social malice on the drinker's social behavior.

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Ethanol‐Induced Oxygen Radical Formation and Lipid Peroxidation in Rat Brain: Effect of Chronic Alcohol Consumption

Cited by 252 publications

References 35 publications

Alcohol stress, membranes, and chaperones

Alcohol stress, membranes, and chaperones

In Vitro Protective Effect of Betaine on Peroxidative Injury Caused By Ethanol and Aspirin Exposure on Rat Brain Synaptosomes

Adverse Consequences of Alcohol Consumption: A Preliminary Study

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