Ethanol-induced Suppression of Resistance to Experimental Infection by<i>Salmonella typhimurium</i>in Mice

Galdiero, F; Nuzzo, I.; Bentivoglio, C.; Galdiero, Massimiliano; Romano-Carratelli, Caterina

doi:10.3109/13590849509000213

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…Moreover, in our earlier studies, we demonstrated that mice maintained on a lipid diet showed an all‐round lowered immunoresponse. In particular, we demonstrated an impaired resistance to experimental infection by Salmonella typhimurium , with increased number of circulating bacteria, diminished adherence and migration capacity of polymorphonuclear leucocytes, diminished response of lymphocytes to polyclonal stimuli and reduced release of cytokines from lymphocytes and monocytes [14, 15].…”

Section: Introductionmentioning

confidence: 96%

The effect of dietary lipid manipulation on murine splenic lymphocytes apoptosis and heat shock protein over expression

Carratelli¹,

Nuzzo²,

Vitiello³

et al. 1999

FEMS Immunology &Amp; Medical Microbiology

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In this study, we kept BALB/c mice on a hyperlipidic diet for 120 days and then assessed the predisposition to apoptosis and the appearance of heat shock protein (Hsp) on splenic lymphocytes. By immunoblot analysis, bands corresponding to Hsp 60 and Hsp 70 in cells from mice kept on a saturated fatty acid diet showed a greater expression already after 1 month while two other bands, which correspond to Hsp 25 and Hsp 27, were slightly present after 1 month of treatment. In cells from mice kept on a diet rich in unsaturated fatty acid, there was a marked expression of Hsp 25 and Hsp 27 after only 30 days of treatment, which was maintained constant for up to 4 months; while for bands corresponding to Hsp 60 and Hsp 70, a significant minor signal was only detectable after 2^4 months from the beginning of the treatment. Splenic lymphocytes from animals kept on a lipidic diet containing saturated fatty acids were more susceptible to death by apoptosis, while cells of animals treated with unsaturated fatty acid were shown to be more resistant. z 1999 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

show abstract

Section: Introductionmentioning

confidence: 96%

The effect of dietary lipid manipulation on murine splenic lymphocytes apoptosis and heat shock protein over expression

Carratelli¹,

Nuzzo²,

Vitiello³

et al. 1999

FEMS Immunology &Amp; Medical Microbiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Moreover, in our earlier studies, we demonstrated that mice maintained on a lipid diet showed an all-round lowered immunoresponse. In particular, we demonstrated an impaired resistance to experimental infection by Salmonella typhimurium, with increased number of circulating bacteria, diminished adherence and migration capacity of polymorphonuclear leucocytes, diminished response of lymphocytes to polyclonal stimuli and reduced release of cytokines from lymphocytes and monocytes [14,15].…”

Section: Introductionmentioning

confidence: 97%

The effect of dietary lipid manipulation on murine splenic lymphocytes apoptosis and heat shock protein over expression

Carratelli

1999

FEMS Immunology and Medical Microbiology

View full text Add to dashboard Cite

In this study, we kept BALB/c mice on a hyperlipidic diet for 120 days and then assessed the predisposition to apoptosis and the appearance of heat shock protein (Hsp) on splenic lymphocytes. By immunoblot analysis, bands corresponding to Hsp 60 and Hsp 70 in cells from mice kept on a saturated fatty acid diet showed a greater expression already after 1 month while two other bands, which correspond to Hsp 25 and Hsp 27, were slightly present after 1 month of treatment. In cells from mice kept on a diet rich in unsaturated fatty acid, there was a marked expression of Hsp 25 and Hsp 27 after only 30 days of treatment, which was maintained constant for up to 4 months; while for bands corresponding to Hsp 60 and Hsp 70, a significant minor signal was only detectable after 2-4 months from the beginning of the treatment. Splenic lymphocytes from animals kept on a lipidic diet containing saturated fatty acids were more susceptible to death by apoptosis, while cells of animals treated with unsaturated fatty acid were shown to be more resistant.

show abstract

Ethanol-induced Suppression of Resistance to Experimental Infection bySalmonella typhimuriumin Mice

Cited by 2 publications

References 12 publications

The effect of dietary lipid manipulation on murine splenic lymphocytes apoptosis and heat shock protein over expression

The effect of dietary lipid manipulation on murine splenic lymphocytes apoptosis and heat shock protein over expression

The effect of dietary lipid manipulation on murine splenic lymphocytes apoptosis and heat shock protein over expression

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