Ethanol inhibition of undifferentiated rat neural progenitor cell replication can be prevented by chlorogenic acid via the NFATc4/CSE signaling pathway
Abstract:BackgroundPrenatal ethanol exposure hinders oxidative stress‐mediated neuroblast/neural progenitor cell proliferation by inhibiting G1‐S transition, a process vital to neocortical development. We previously showed that ethanol elicits this redox imbalance by repressing cystathionine γ‐lyase (CSE), the rate‐limiting enzyme in the transsulfuration pathway in fetal brain and cultured cerebral cortical neurons. However, the mechanism by which ethanol impacts the CSE pathway in proliferating neuroblasts is not know… Show more
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