Ethanol-mediated synthesis of γ-cyclodextrin-based metal-organic framework as edible microcarrier: performance and mechanism

Wang, Zonghan; Zhou, Da‐Yong; Liu, Donghong; Zhu, Beiwei

doi:10.1016/j.foodchem.2023.136000

Cited by 17 publications

(23 citation statements)

References 29 publications

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“…Within the framework, EGCG molecules had an ordered anchor in both the inherent cavity of cyclodextrin and the newly formed tunnels in the frameworks. 11 Here, a series of well-defined diffraction peaks in the X-ray diffraction (XRD) pattern for EGCG@CD-MOFs also demonstrated the presence of a framework structure. Specifically, the well-defined diffraction peaks at 4.9, 5.7, 7.0, 8.9, 9.8, 13.3, 16.1, 16.6, 17.1, and 17.5 were attributed to the (110), ( 200), ( 211), (310), ( 222), ( 332), ( 440), ( 433), (600), and (611) crystal planes, respectively.…”

Section: Structural Transformation Of Egcg@cd-mofs In Aqueous Solutio...mentioning

confidence: 69%

“…This superiority in arrangement brought a unique framework in EGCG@CD-MOFs, where EGCG molecules obtained ordered encapsulation within cavities and tunnels of the framework. 11 Furthermore, this ordered encapsulation of EGCG molecules has even been verified to contribute to their stability and functionality as a cross-linker in the thermal−gelation process of shrimp surimi products (unpublished data). In this study, shrimp surimi was selected as a model to investigate the feasibility of ordered encapsulation within EGCG@CD-MOFs as an effective method to mitigate the auto-browning of EGCG in high-humidity conditions.…”

Section: Introductionmentioning

confidence: 86%

“…The EGCG@CD-MOFs used in this work were synthesized using an ethanol-mediated method published in our initial work. 11 Operating details are presented in the Supporting Information. The loading capability of EGCG within EGCG@CD-MOF was determined as 249.8 ± 0.57 mg/g through a typical method, with more details present in the Supporting Information.…”

Section: Methodsmentioning

confidence: 99%

“…The static structure mode of EGCG@CD-MOF was obtained through molecular docking, according to the published program in our initial work. 11 The crystallographic data for CD-MOF was acquired from CCDC 773709 (https://www.ccdc.cam.ac.uk/). The structural data for EGCG was acquired from the PubChem database (https://pubchem.ncbi.nlm.nih.…”

Section: Molecular Dynamics (Md) Simulationsmentioning

confidence: 99%

“…In preliminary studies, we have constructed an edible cyclodextrin metal–organic framework (CD-MOF) as an efficient microcarrier for EGCG . Different from the random arrangement mode of the inclusion structure in complexes, a periodic arrangement linked by coordinate bonds was achieved in EGCG@CD-MOFs.…”

Section: Introductionmentioning

confidence: 99%

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Encapsulation Alleviates the Auto-browning of Epigallocatechin-3-gallate in Aqueous Solutions through Regulating Molecular Self-Aggregation Behavior

Wang,

Yin,

et al. 2023

J. Agric. Food Chem.

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Catechins are widely recognized for superb antioxidant capability, but their application as food antioxidants is hindered by susceptibility to auto-browning under high-moisture conditions. Here, we proposed a strategy of ordered encapsulation with cyclodextrin-based metal–organic frameworks (CD-MOFs) to alleviate the auto-browning phenomenon of catechins while preserving their antioxidant capability and demonstrated the feasibility of this strategy via selecting epigallocatechin-3-gallate (EGCG) as a model. Even in aqueous solutions, EGCG@CD-MOFs still possessed delayed browning, in contrast with pristine EGCG, characterized by suppressed efficiencies on the generation of oxidative dimers (theasinensin A) and semiquinone radicals. Mechanism insights revealed that ordered encapsulation brought dual regulations on the self-aggregation behavior of EGCG: EGCG@CD-MOFs exhibited a gradual structural collapse from the framework toward irregular aggregates as O–K bonds broke progressively, which restricted molecular mobility of EGCG, and EGCG molecular conformations became constrained by the structure of EGCG@CD-MOFs as well as rich intermolecular forces, even after structural collapse.

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Section: Structural Transformation Of Egcg@cd-mofs In Aqueous Solutio...mentioning

confidence: 69%

Section: Introductionmentioning

confidence: 86%

Section: Methodsmentioning

confidence: 99%

Section: Molecular Dynamics (Md) Simulationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Encapsulation Alleviates the Auto-browning of Epigallocatechin-3-gallate in Aqueous Solutions through Regulating Molecular Self-Aggregation Behavior

Wang,

Yin,

et al. 2023

J. Agric. Food Chem.

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Application of Metal‐Organic Frameworks in Imaging‐Guided Therapy

Zhu,

Ke,

Zhao

et al. 2023

Analysis & Sensing

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Metal‐organic frameworks (MOFs) are formed by the self‐assembly of metal centres/clusters and organic ligands. A diverse range of organic ligands can be employed, including nucleobases, amino acids, peptides, proteins, and saccharides et al. Due to the characteristics of large surface area, high porosity, easy surface functionalization and adjustable internal pore size, et al. MOFs have been used as a significant emerging class of biological imaging agents and have attracted great research interest in optical imaging (OI), photoacoustic imaging (PAI), magnetic resonance imaging (MRI), computer tomography (CT) and positron emission tomography (PET) in recent years. This review provides a comprehensive overview of the diverse range of organic ligands utilized in metal‐organic frameworks, while also delving into the recent advancements, opportunities, and challenges encountered in the realm of bioimaging in recent years.

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