Ethanol Narcosis in Mice: Effects of &lt;i&gt;L&lt;/i&gt;-dopa, its Metabolites and Other Experimental Variables

Messiha, F.S.; Morgan, MY; Geller, Irving

doi:10.1159/000136923

Cited by 16 publications

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both hypoxia, to which mice are particularly sensitive (Kent et al, 1977), and excess hypo thermia would be expected to increase sleep time (Mustala and SAzarnoff. 1969;Belaud et al, 1977;Cherkin and Catchpool, 1964;Messiha et al. 1975) and may have obscured a pressure-related antagonism.…”

Section: Introductionmentioning

confidence: 99%

Low-Level Hyperbaric Ethanol Antagonism in Mice

Alkana¹,

Malcolm²

1981

Pharmacology

View full text Add to dashboard Cite

Dose- and pressure-related interactions between ethanol anesthesia and low-level hyperbaric helium-oxygen environments were studied in mice using conditions which eliminated the possibility of hypoxia during compression and hyperbaric helium-induced hypothermia. Hyperbaric helium-oxygen (1–12 atmospheres absolute) reduced sleep time in a pressure-related manner. The degree of maximum ethanol antagonism decreased as the ethanol dose increased (3.2, 3.6, and 4.0g/kg). The results are consistent with membrane theories of general anesthesia and suggest a possible common mechanism between ethanol antagonism at low hyperbaric pressure and high-pressure reversal of anesthesia.

show abstract

Section: Introductionmentioning

confidence: 99%

Low-Level Hyperbaric Ethanol Antagonism in Mice

Alkana¹,

Malcolm²

1981

Pharmacology

View full text Add to dashboard Cite

show abstract

Differential response of NADP‐linked hepatic aldehyde dehydrogenase toward taurine: Implication for behavioural effects of ethanol

Messiha¹

1987

J of Applied Toxicology

View full text Add to dashboard Cite

The effects of taurine, its initial precursor L-cysteine, and the major metabolite taurocholic acid on two ethanol-mediated responses in rodents were studied. Administration of a single dose of taurocholic acid reduced voluntary intake of a 5% ethanol solution by the rat. In the mouse, taurine had no effect on alcohol drinking or on the central depressant action of ethanol, as measured by the duration of ET-produced loss of the righting reflex. Likewise, taurocholic acid and L-cysteine did not significantly influence the duration of ethanol-narcosis time from control mice. Also studied were the effects of acute and short-term (7 or 10 days) administration of these compounds on hepatic ethanol and acetaldehyde metabolizing enzymes. Short-term administration of an equimolar concentration of taurine enhanced endogenous NADP-linked rat liver aldehyde dehydrogenase (L-ALDH) as contrasted with inhibition of the same enzyme by L-cysteine. Short-term (7 days) treatment with L-cysteine induced rat liver NAD-linked ALDH, but acute (single dose) treatment did not. Taurocholic acid short-term administration caused an induction and an inhibition of endogenous mouse liver alcohol dehydrogenase (L-ADH) and L-ALDH, respectively. The results suggest that taurine does not directly interact with ethanol. However, its major metabolite, taurocholic acid, may cause rapid metabolic conversion of ethanol to acetaldehyde by induction of L-ADH, which is then slowly metabolized due to a concomitant inhibition of L-ALDH. This may cause a build-up of acetaldehyde and thereby produce adverse reactions similar to those resulting from the combination of disulfiram and ethanol.

show abstract

Alcohol- and Aldehyde-Dehydrogenase: Modulation By Biogenic Amine Metabolites, Neuropeptides and Psychoactive Agents

Messiha

1993

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

Ethanol Narcosis in Mice: Effects of <i>L</i>-dopa, its Metabolites and Other Experimental Variables

Cited by 16 publications

References 11 publications

Low-Level Hyperbaric Ethanol Antagonism in Mice

Low-Level Hyperbaric Ethanol Antagonism in Mice

Differential response of NADP‐linked hepatic aldehyde dehydrogenase toward taurine: Implication for behavioural effects of ethanol

Alcohol- and Aldehyde-Dehydrogenase: Modulation By Biogenic Amine Metabolites, Neuropeptides and Psychoactive Agents

Contact Info

Product

Resources

About