Ethanol perturbs lipid organization in models of stratum corneum membranes: An investigation combining differential scanning calorimetry, infrared and 2H NMR spectroscopy

Kwak, Sungjong; Brief, Elana; Langlais, Denis; Kitson, Neil; Lafleur, Michel; Thewalt, Jenifer

doi:10.1016/j.bbamem.2012.02.013

Cited by 50 publications

(42 citation statements)

References 59 publications

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“…30) In addition, ethanol has been reported to extract and fluidize SC lipids. [31][32][33] Dimethyl sulfoxide has been shown to change keratin conformation and also interact with SC lipids. 34,35) However, the interactions of these CPEs with SC lipids was mainly on the polar head region.…”

Section: Discussionmentioning

confidence: 99%

Potential of Stratum Corneum Lipid Liposomes for Screening of Chemical Skin Penetration Enhancers

Sakdiset

Todo

Sugibayashi

2017

CHEMICAL & PHARMACEUTICAL BULLETIN

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The evaluation of effective skin chemical penetration enhancers (CPEs) is a crucial process in the development of transdermal and dermal formulations with the capacity to overcome the stratum corneum barrier. In the present study, we aimed to investigate the potential of stratum corneum lipid liposomes (SCLLs) as an alternative tool for the screening of various types and concentrations of CPEs. SCLLs were prepared using a thin-film hydration technique, and two types of fluorescent probes ( Key words stratum corneum lipid liposome; chemical skin penetration enhancer; liposome; high-throughput screening Skin has been recognized as an application site of therapeutic drugs for several decades. However, only small numbers of drugs are available nowadays intended for systemic absorption through the skin. The stratum corneum (SC), the outermost layer of the skin, provides a strong barrier to protect against extraneous molecules from entering the body, and thus limits the skin penetration of drugs. The structure of the SC consists of keratin-rich corneocytes embedded in an intercellular lipid matrix.

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Section: Discussionmentioning

confidence: 99%

Potential of Stratum Corneum Lipid Liposomes for Screening of Chemical Skin Penetration Enhancers

Sakdiset

Todo

Sugibayashi

2017

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…Treatment of the skin with some chemicals such as acetone and ethanol causes barrier disruption due to extraction of SC lipids [71,72]. Imokawa et al [73] reported that the application of 5% SDS aqueous solution to human forearm skin resulted in a chapped and scaly SC without any inflammatory reaction.…”

Section: Factors Affecting the Composition And Organization Of Sc Lipidsmentioning

confidence: 99%

Skin Diseases Associated with the Depletion of Stratum Corneum Lipids and Stratum Corneum Lipid Substitution Therapy

Sahle

Gebre‐Mariam²,

Dobner³

et al. 2014

Skin Pharmacol Physiol

170

164

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The skin is the largest organ of the body, whose main function is to protect the body against the loss of physiologically important components as well as harmful environmental insults. From the inside to the outside, the skin comprises three major structural layers: the hypodermis, the dermis and the epidermis. The epidermis contains four different sublayers, the stratum corneum (SC), stratum granulosum, stratum spinosum and stratum basale, where the barrier function of the skin mainly lies in the outermost layer of the epidermis, the SC. The SC contains corneocytes that are embedded in a lipid matrix existing in the form of lipid bilayers. The lipid bilayers are formed mainly from ceramides, free fatty acids and cholesterol, constitute the only continuous pathway across the SC and are responsible for the barrier function of the skin. However, the depletion or disturbance of SC lipids in the SC leads to a perturbation of the barrier function of the skin, and, conversely, several skin diseases such as psoriasis and atopic dermatitis are associated with the depletion of these SC lipids. Therefore, it is of paramount importance to understand the interrelationship between the depletion of SC lipids and skin diseases as well as factors that affect the composition and organization of SC lipids in order to assess the potential benefit of a direct replacement of the missing SC lipids as a means of treating affected, aged or diseased skin. i 2014 S. Karger AG, Basel

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“…Ethanol-induced oxidative stress is the result of the combined impairment of antioxidant defenses and the production of reactive oxygen species (ROS) by the mitochondrial electron transport chain, the alcohol-inducible cytochrome P450 (CYP) 2E1 and activated phagocytes and hydroxyethyl free radicals generated during alcohol metabolism by CYP 2E1 [6,9]. ROS, in turn, are able to damage or cause complete degradation of essential complex molecules in the cells, including lipids, proteins and DNA [6,10,11,12]. …”

Section: Introductionmentioning

confidence: 99%

Alcohol Consumption Decreases the Protection Efficiency of the Antioxidant Network and Increases the Risk of Sunburn in Human Skin

Darvin

Sterry

Lademann

et al. 2012

Skin Pharmacol Physiol

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In recent years, epidemiological data has demonstrated that alcohol consumption is a risk factor for sunburn, melanoma and nonmelanoma skin cancer. We hypothesized that if the concentration of the antioxidants in the skin has already decreased due to alcohol consumption, then an adequate neutralization of the free radicals induced by ultraviolet light cannot be performed. Based on this hypothesis, we determined the carotenoid concentration in the skin and the minimal erythema dose (MED) of 6 male human volunteers before and after consumption of alcohol or alcohol and orange juice combined. The results showed a significant decrease in the carotenoid concentration in the skin and the MED after alcohol consumption, but no significant decrease after a combined intake of alcohol and orange juice.

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Ethanol perturbs lipid organization in models of stratum corneum membranes: An investigation combining differential scanning calorimetry, infrared and 2H NMR spectroscopy

Cited by 50 publications

References 59 publications

Potential of Stratum Corneum Lipid Liposomes for Screening of Chemical Skin Penetration Enhancers

Potential of Stratum Corneum Lipid Liposomes for Screening of Chemical Skin Penetration Enhancers

Skin Diseases Associated with the Depletion of Stratum Corneum Lipids and Stratum Corneum Lipid Substitution Therapy

Alcohol Consumption Decreases the Protection Efficiency of the Antioxidant Network and Increases the Risk of Sunburn in Human Skin

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