Ethanol perturbs the secretory pathway in astrocytes

Tomàs, Mariona; P, Marín; Megías, Luis; Egea, Gustavo; Renau‐Piqueras, Jaime

doi:10.1016/j.nbd.2005.05.012

Cited by 40 publications

(55 citation statements)

References 58 publications

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“…These data are consistent with recent evidence showing that ethanol disrupts the Golgi complex and microtubule-transport mechanisms (Azorin et al, 2004;Tomas et al, 2005), so that protein processing and secretion, rather than gene transcription per se, is the immediate ethanol target. Monocyte chemotactic protein-1 was an exception to the above observations, as the relative ethanol-induced suppression of MCP-1 mRNA levels was substantially greater than the observed suppression of the secreted protein product, suggesting that neural precursors at least partly compensate for the loss of MCP-1 mRNA.…”

Section: The Discrepancy Between Cytokine Secretion and Mrna Levels Ssupporting

confidence: 92%

Ethanol Regulates Angiogenic Cytokines During Neural Development: Evidence From an in Vitro Model of Mitogen‐Withdrawal–Induced Cerebral Cortical Neuroepithelial Differentiation

Camarillo

Kumar

Bake

et al. 2007

Alcoholism Clin & Exp Res

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Embryonic cerebral cortical neuroepithelial-derived precursors secrete high levels of several angiogenic and neural-growth-promoting cytokines as they differentiate into neurons. Our data collectively suggest that ethanol exposure during the period of neuroepithelial proliferation significantly disrupts cytokine signals that are required for the support of emerging neurovascular networks, and the maintenance of neural stem cell beds.

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Section: The Discrepancy Between Cytokine Secretion and Mrna Levels Ssupporting

confidence: 92%

Ethanol Regulates Angiogenic Cytokines During Neural Development: Evidence From an in Vitro Model of Mitogen‐Withdrawal–Induced Cerebral Cortical Neuroepithelial Differentiation

Camarillo

Kumar

Bake

et al. 2007

Alcoholism Clin & Exp Res

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“…We have characterized several mechanisms by which ethanol affects astrocyte secretion: Ethanol reduces the release of neuritogenic ECM proteins laminin and fibronectin stimulated by muscarinic receptors in astrocytes (35), which may be due to the perturbation of the secretory pathway induced by ethanol in astrocytes (118). …”

Section: Astrocytes and Fasdmentioning

confidence: 99%

Glia and Neurodevelopment: Focus on Fetal Alcohol Spectrum Disorders

et al. 2014

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During the last 20 years, new and exciting roles for glial cells in brain development have been described. Moreover, several recent studies implicated glial cells in the pathogenesis of neurodevelopmental disorders including Down syndrome, Fragile X syndrome, Rett Syndrome, Autism Spectrum Disorders, and Fetal Alcohol Spectrum Disorders (FASD). Abnormalities in glial cell development and proliferation and increased glial cell apoptosis contribute to the adverse effects of ethanol on the developing brain and it is becoming apparent that the effects of fetal alcohol are due, at least in part, to effects on glial cells affecting their ability to modulate neuronal development and function. The three major classes of glial cells, astrocytes, oligodendrocytes, and microglia as well as their precursors are affected by ethanol during brain development. Alterations in glial cell functions by ethanol dramatically affect neuronal development, survival, and function and ultimately impair the development of the proper brain architecture and connectivity. For instance, ethanol inhibits astrocyte-mediated neuritogenesis and oligodendrocyte development, survival and myelination; furthermore, ethanol induces microglia activation and oxidative stress leading to the exacerbation of ethanol-induced neuronal cell death. This review article describes the most significant recent findings pertaining the effects of ethanol on glial cells and their significance in the pathophysiology of FASD and other neurodevelopmental disorders.

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“…In chronically ethanoltreated rats, the rate of tubulin polymerization and the microtubule reorganization were altered, while the level of expression of tubulin was unchanged in the damaged liver (Yoon et al 1998). In an ethanol treated astrocyte culture, the actin cytoskeleton and the entire microtubular network appeared to be disrupted and disorganized (Tomas et al 2003;Tomas et al 2005). Acute ethanol treatment resulted in disruption of the actin network and enhanced ROS formation in the C6 rat glioma cell line.…”

Section: The Effects Of Alcohol On Cellular Physiologymentioning

confidence: 99%

Alcohol stress, membranes, and chaperones

Tóth

Vı́gh

Sántha

2014

Cell Stress and Chaperones

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Ethanol, which affects all body organs, exerts a number of cytotoxic effects, most of them independent of cell type. Ethanol treatment leads to increased membrane fluidity and to changes in membrane protein composition. It can also interact directly with membrane proteins, causing conformational changes and thereby influencing their function. The cytotoxic action may include an increased level of oxidative stress. Heat shock protein molecular chaperones are ubiquitously expressed evolutionarily conserved proteins which serve as critical regulators of cellular homeostasis. Heat shock proteins can be induced by various forms of stresses such as elevated temperature, alcohol treatment, or ischemia, and they are also upregulated in certain pathological conditions. As heat shock and ethanol stress provoke similar responses, it is likely that heat shock protein activation also has a role in the protection of membranes and other cellular components during alcohol stress.

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Ethanol perturbs the secretory pathway in astrocytes

Cited by 40 publications

References 58 publications

Ethanol Regulates Angiogenic Cytokines During Neural Development: Evidence From an in Vitro Model of Mitogen‐Withdrawal–Induced Cerebral Cortical Neuroepithelial Differentiation

Ethanol Regulates Angiogenic Cytokines During Neural Development: Evidence From an in Vitro Model of Mitogen‐Withdrawal–Induced Cerebral Cortical Neuroepithelial Differentiation

Glia and Neurodevelopment: Focus on Fetal Alcohol Spectrum Disorders

Alcohol stress, membranes, and chaperones

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