Ethanol reduces bone formation and may cause osteoporosis

Diamond, Terrence; Stiel, Daniel; Lunzer, Michael; Wilkinson, M. C.; Posen, Solomon

doi:10.1016/0002-9343(89)90297-0

Cited by 263 publications

(139 citation statements)

References 40 publications

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“…This investigation verified that the effects of alcoholism on the bone tissue are related to several osteopathologies, as described by other authors (Baran et al, 1980;Lorenz and Lorenz, 1984;Crilly et al, 1988;Lieber, 1988;Friday e Howard, 1991;Compston, 1992;Felson, 1995;Garcia-Sanchez et al, 1995;Klein, 1997), also leading to an increased propensity to fractures, as stated by other authors (Erhart, 1962;Johnell et al, 1982;Diamont et al, 1989;Fortes and Cardo, 1991;Levy, 1991;Bikle, 1993;Chavassieux, 1993;Balzan, 2001). However, they make no mention about the effects of alcoholism on the process of fracture regeneration.…”

Section: Discussion Discussion Discussionsupporting

confidence: 89%

“…It was found that the protein synthesis, the fosfatase alkaline activity and the cellular proliferation diminished after ethanol treatment. These finds agree with the results obtained by Grilly and Anderson (1988) and Diamont et al (1989), which evidenced through histomorphomeric analysis a reduction in osseous formation with deficit in number of osteoblast per osseous surface in alcohol addicted patients.…”

Section: Introduction Introduction Introduction Introductionsupporting

confidence: 92%

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Indução à ingestão de álcool etílico retarda o processo de regeneração pós-fratura em rato

Pereira

Conegero

2007

Acta Sci. Biol. Sci.

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Section: Discussion Discussion Discussionsupporting

confidence: 89%

Section: Introduction Introduction Introduction Introductionsupporting

confidence: 92%

Indução à ingestão de álcool etílico retarda o processo de regeneração pós-fratura em rato

Pereira

Conegero

2007

Acta Sci. Biol. Sci.

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“…Diminished BMD has been reported in patients with alcoholic liver disease, [10][11][12][13][14] alcoholic subjects without cirrhosis, 15,16 patients with pri- mary biliary cirrhosis, [3][4][5] and patients with hemochromatosis, 8,9 but little has been published on viral cirrhotic patients without a history of alcohol consumption. In our study, bone densities in the FN and LS were significantly lower in viral cirrhotic patients than in the reference population, and this reduction was more severe in LS (trabecular bone) than FN (cortical bone), probably because the rate of turnover in cortical bone is much lower than in trabecular bone.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2] Several studies have shown diminished bone formation rates in patients with cholestatic liver disease, [3][4][5] corticosteroid-treated chronic active hepatitis, [6][7] hemochromatosis, [8][9] and alcoholic liver disease. [10][11][12][13][14] Some studies also showed reduced bone formation rates in alcoholic subjects without cirrhosis. [15][16] Nevertheless, little is known about the effect of viral cirrhosis and of the severity of liver disease on bone mass and bone turnover.…”

mentioning

confidence: 99%

Bone mineral density, serum insulin-like growth factor I, and bone turnover markers in viral cirrhosis

et al. 1998

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Previous studies suggest that low bone mass is a complication of alcoholic liver disease. Nevertheless, little is known about bone mass and bone metabolism in viral cirrhosis. To evaluate the prevalence and magnitude of hepatic osteopenia in these patients, bone remodeling status, and its relationship with the severity of liver disease and serum levels of insulin-like growth factor I (IGF-I), we studied 32 consecutive patients with viral cirrhosis and no history of alcohol intake. Bone mineral density (BMD) was measured by dual x-ray absorptiometry in the lumbar spine (LS) and femoral neck (FN), and the values were expressed as the z score. Bone metabolism markers and hormone profiles were measured. Patients with viral cirrhosis showed reduced BMD in all sites (LS: ؊1.27 ؎ 1.06, P F .001; FN: ؊0.48 ؎ 0.96; P F .01). Of the 32 patients, 53% met the diagnostic criteria for osteoporosis. In patients, urine deoxypyridinoline (D-Pyr) as a marker of bone resorption and serum bone alkaline phosphatase (b-AP) as a marker of bone formation were significantly higher than in control subjects (P F .001 and P F .01, respectively). Serum IGF-I was lower than in control subjects (P F .001), and significant differences were also found between patients with and without osteoporosis (P F .05). BMD in LS correlated with severity of the disease, with serum levels of IGF-I, and with urine D-Pyr. Our findings show that viral cirrhosis is a major cause of osteoporosis in men, and that low serum IGF-I levels seem to play a role in the bone mass loss in these patients. The biochemical markers of bone remodeling suggest high-turnover osteoporosis in patients with viral cirrhosis. (HEPATOLOGY 1998;28:695-699.)

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“…Reduction in the grade of bone formation has been observed in alcoholic patients by bone biopsies, with low serum levels of osteocalcin during alcohol intake, which normalizes with abstinence [30]. Some authors demonstrate that alcoholic men, with or without mild liver disease, have significantly lower lumbar BMD than controls, and 29% have osteoporosis.…”

Section: Alcoholic Liver Diseasementioning

confidence: 99%

Osteodystrophy in chronic liver diseases

et al. 2012

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Osteoporosis and osteomalacia are, to date, among the most common metabolic diseases in the world. Lately, an association between metabolic bone diseases and chronic liver disease has been increasingly reported, inducing many authors to create a new nosographic entity known as 'hepatic osteodystrophy. ' The importance of such a condition is further increased by the morbidity of these two diseases, which greatly reduce the quality of life because of frequent fractures, especially vertebral and femoral neck ones. For this reason, early identification of high-risk patients should be routinely performed by measuring bone mass density. The explanation for the association between bone diseases and chronic liver disease is still uncertain, and involves many factors: from hypogonadism to use of corticosteroid drugs, from genetic factors to interferon therapy. To date, few studies have been conducted, and all with a small number of patients to establish definitive conclusions about the possible treatment, but some evidence is beginning to emerge about the safety and efficacy of bisphosphonates.

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Ethanol reduces bone formation and may cause osteoporosis

Cited by 263 publications

References 40 publications

Indução à ingestão de álcool etílico retarda o processo de regeneração pós-fratura em rato

Indução à ingestão de álcool etílico retarda o processo de regeneração pós-fratura em rato

Bone mineral density, serum insulin-like growth factor I, and bone turnover markers in viral cirrhosis

Osteodystrophy in chronic liver diseases

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