Ethanol's Effects on Gait Dynamics in Mice Investigated by Ventral Plane Videography

Kale, Ajit; Amende, Ivo; Meyer, G.; Crabbe, John C.; Hampton, Thomas G.

doi:10.1097/01.alc.0000148103.09378.81

Cited by 52 publications

(49 citation statements)

References 44 publications

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“…Ventral plane videography captured the gait of each mouse through a transparent, motor-driven treadmill belt (Kale et al, 2004;Amende et al, 2005). Digital images of the paws of each mouse were taken at 150 frames/s as mice walked at a speed of 24 cm/s.…”

Section: Motor Behavior Analysismentioning

confidence: 99%

Intervention with 7,8-dihydroxyflavone blocks further striatal terminal loss and restores motor deficits in a progressive mouse model of Parkinson’s disease

et al. 2015

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Section: Motor Behavior Analysismentioning

confidence: 99%

Intervention with 7,8-dihydroxyflavone blocks further striatal terminal loss and restores motor deficits in a progressive mouse model of Parkinson’s disease

et al. 2015

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“…Ventral plane videography, as previously described, captured the gait of each mouse through a transparent, motor-driven treadmill belt (Kale et al, 2004;Amende et al, 2005). Digital images of the paws of each mouse were taken at 150 frames/sec as mice walked at a speed of 24 cm/sec.…”

Section: Gait Dynamicsmentioning

confidence: 99%

Profiling changes in gait dynamics resulting from progressive 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced nigrostriatal lesioning

Goldberg

Hampton

McCue

et al. 2011

J of Neuroscience Research

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Current behavioral measurements for motor impairment are not consistently sensitive in rodent models of partial nigrostriatal dopamine (DA) depletion. In addition to exploratory and somatosensory behavior, motor skills that are thought to be directly translatable to human Parkinson's disease patients are assessed. However, many of these motor tests require the training and learning of particular tasks, so it cannot be determined whether impairments are due to motor or to learning deficit. Therefore, we have quantified multiple temporal and spatial indices of gait dynamics in a model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced partial nigrostriatal lesioning using a treadmill apparatus requiring no prior training. Three days following the cessation of progressively increased MPTP administration, rearing and foot-fault behaviors showed significant deficit. Ten days after the final MPTP injection, gait dynamics were assessed and indicated differences between MPTP- and vehicle-treated animals. The major significant changes were in stride length, frequency, duration, and number of steps. Three weeks following a progressively increased dose of MPTP (administered 5 days per week over the course of 4 weeks), mice showed a 63% decrease in tyrosine hydroxylase-immunoreactive (TH-ir) nigrostriatal neurons in the substantia nigra pars compacta and a 72% decrease in TH-ir terminals in the caudate-putamen. This suggests that there is a continued effect of progressively increased MPTP on nigrostriatal DA neurons, correlated with rearing and foot-fault behaviors and further characterized by differences in temporal and spatial measurements of gait dynamics.

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“…A ventral plane videography apparatus using a clear treadmill [15,22] was chosen to analyze the gait indices of mice at a constant speed (Fig. 3), compared to traditional "paw painting" techniques that do not control speed.…”

Section: Behavioral Effects Of Msra Targeted Deletionmentioning

confidence: 99%

MsrA knockout mouse exhibits abnormal behavior and brain dopamine levels

Oien

Osterhaus

Latif

et al. 2008

Free Radical Biology and Medicine

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Oxidative stress can cause methionine oxidation that has been implicated in various proteins malfunctions, if not adequately reduced by the methionine sulfoxide reductase system. Recent evidence has found oxidized methionine residues in neurodegenerative conditions. Previously, we have described elevated levels of brain pathologies and an abnormal walking pattern in the methionine sulfoxide reductase A knockout (MsrA −/− ) mouse. Here we show that MsrA −/− mice have compromised complex task learning capabilities relative to wild-type mice. Likewise, MsrA −/− mice exhibit lower locomotor activity and altered gait that exacerbated with age. Furthermore, MsrA −/− mice were less responsive to amphetamine treatment. Consequently, brain dopamine levels were determined. Surprisingly, relative to wild-type mice, MsrA −/− brains contained significantly higher levels of dopamine up to 12 months of age, while lower level of dopamine was observed at 16 months of age. Moreover, striatal regions of MsrA −/− mice showed an increase of dopamine release parallel to observed dopamine levels. Similarly, the expression pattern of tyrosine hydroxylase activating protein correlated with the age-dependent dopamine levels. Thus, it is suggested that dopamine regulation and signaling pathway are impaired in MsrA −/− mice, which may contribute to their abnormal bio-behavior. These observations may be relevant to age-related neurological diseases associated with oxidative stress.

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Ethanol's Effects on Gait Dynamics in Mice Investigated by Ventral Plane Videography

Cited by 52 publications

References 44 publications

Intervention with 7,8-dihydroxyflavone blocks further striatal terminal loss and restores motor deficits in a progressive mouse model of Parkinson’s disease

Intervention with 7,8-dihydroxyflavone blocks further striatal terminal loss and restores motor deficits in a progressive mouse model of Parkinson’s disease

Profiling changes in gait dynamics resulting from progressive 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced nigrostriatal lesioning

MsrA knockout mouse exhibits abnormal behavior and brain dopamine levels

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