Ethanol stimulates apolipoprotein A-I secretion by human hepatocytes: Implications for a mechanism for atherosclerosis protection

Amarasuriya, Rowan N.; Gupta, Alok; Civen, Morton; Horng, Yeong-Chuan; Maeda, Toshio; Kashyap, Moti L.

doi:10.1016/0026-0495(92)90162-4

Cited by 60 publications

(13 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increased plasma apo A-I concentration is associated with an increased synthesis of apo A-I in the liver, [105][106][107] which may be related to the alcohol-induction of liver 105,108 There are only a few studies exploring the effects of alcohol consumption on HDL apo A-I and apo A-II turnover in human subjects and the results are partly contradictory. 88,103,106 The transport rate of apo A-I has been reported to be unchanged 88 or increased, 103,106 and the fractional catabolic rate of apo A-I unchanged 88,103 or increased, but to a lesser extent than the synthetic rate, 106 leading to an increased plasma concentration of apo A-I.…”

Section: E Apolipoproteinsmentioning

confidence: 97%

Effect of Alcohol on Lipids and Lipoproteins in Relation to Atherosclerosis

Hannuksela

Liisanantti

Savolainen

2002

Critical Reviews in Clinical Laboratory Sciences

View full text Add to dashboard Cite

Several studies indicate that light-to-moderate alcohol consumption is associated with a low prevalence of coronary heart disease. An increase in high-density lipoprotein (HDL) cholesterol is associated with alcohol intake and appears to account for approximately half of alcohol's cardioprotective effect. In addition to changes in the concentration and composition of lipoproteins, alcohol consumption may alter the activities of plasma proteins and enzymes involved in lipoprotein metabolism: cholesteryl ester transfer protein, phospholipid transfer protein, lecithin:cholesterol acyltransferase, lipoprotein lipase, hepatic lipase, paraoxonase-1 and phospholipases. Alcohol intake also results in modifications of lipoprotein particles: low sialic acid content in apolipoprotein components of lipoprotein particles (e.g., HDL apo E and apo J) and acetaldehyde modification of apolipoproteins. In addition, "abnormal" lipids, phosphatidylethanol, and fatty acid ethyl esters formed in the presence of ethanol are associated with lipoproteins in plasma. The effects of lipoproteins on the vascular wall cells (endothelial cells, smooth muscle cells, and monocyte/macrophages) may be modulated by ethanol and the alterations further enhanced by modified lipids. The present review discusses the effects of alcohol on lipoproteins in cholesterol transport, as well as the novel effects of lipoproteins on vascular wall cells.

show abstract

Section: E Apolipoproteinsmentioning

confidence: 97%

Effect of Alcohol on Lipids and Lipoproteins in Relation to Atherosclerosis

Hannuksela

Liisanantti

Savolainen

2002

Critical Reviews in Clinical Laboratory Sciences

View full text Add to dashboard Cite

show abstract

“…More convincingly, when healthy human subjects are switched from 4 weeks of abstinence to 4 weeks of moderate alcohol consumption (13), there is a significant rise in plasma HDL at the end of that period that falls once more when alcohol is withdrawn (Figure 2). Experiments with cultured human liver cells have shown that alcohol acts directly upon these cells to increase their production of the A-lipoproteins that form the structure of the HDL particle (14).…”

Section: High-density Lipoproteinsmentioning

confidence: 99%

Wine and Health: A Paradigm for Alcohol and Antioxidants

Goldberg¹,

Soleas²

2011

Journal of Medical Biochemistry

View full text Add to dashboard Cite

Kratak sadr`aj: Mnoga epidemiolo{ka istra`ivanja su poka zala da umereno konzumiranje alkohola produ`ava o~e -kivani `ivotni vek tako {to smanjuje rizik od izvesnih bolesti. Pomenuti smanjeni rizik najva`niji je kod koronarne sr~ane bolesti i ishemijskog mo`danog udara, koje izaziva ate rosklerotska vaskularna bolest. Postoje tvrdnje da takvi efekti zavise od vrste pi}a, kao i da crno vino ima najmo } nije dejstvo. Ovaj pregled ispita}e relativni doprinos etanola i polifenolskih antioksidanata iz crnog vina, razmatraju}i njihov potencijal da inhibiraju aterogenezu i njene meha nizme. Postoji valjani dokazi, kako in vitro tako i in vivo, da etanol pove}ava produkciju i cirkuli{u}e nivoe HDL-holeste rola i smanjuje formiranje ugru{aka tako {to blokira aktiv nost trombina i inhibiciju fibrinolize. Na taj na~in spreava migraciju glatkih mi{i}nih }elija u intimalni sloj arterija i sni`ava incidencu dijabetes melitusa tipa 2, kao va`nog faktora rizika za aterosklerotsku bolest. Crno vino pored etanola sadr`i mnoge polifenolske antioksidante tako|e prisutne u vo}u i povr}u (npr. katehin i kvercetin), kao i rezveratrol koji se gotovo isklju~ivo nalazi u gro`|u i crnom vinu. U in vitro eksperimentima pokazano je da ti polifenoli, naro~ito rezveratrol, iskazuju mo}na svojstva koja omogu}avaju spre~avanje ateroskleroze. Pored toga {to smanjuju formiranje ugru{aka, oni ubla`avaju inflamatorne reakcije regulisanjem produkcije eikozanoida i citokina, spre~avaju oksidaciju LDL, smanjuju ekspresiju molekula }elijske adhezije i pove}avaju produkciju NO. Me|utim, istra`ivanja nà ivotinjama i ljudima dala su protivre~ne rezultate. Taj paradoks mogu objasniti studije koje pokazuju da te polifenole, uzete oralno, mukoza tankog creva brzo konjuguje sa glukuronidom i sulfatom pre apsorpcije, posle ~ega bubrezi Summary: Moderate alcohol consumption has been shown in many epidemiological investigations to prolong overall life expectancy by reducing the risk of certain diseases. Those that account most for this reduction are coronary heart disease and ischemic stroke, both of which are caused by atherosclerotic vascular disease. It has been claimed that these effects are beverage-specific, with red wine being the most potent. This review examines the relative contributions of ethanol and the polyphenolic antioxidants of red wine by considering their potential to inhibit atherogenesis and the mechanisms involved. There is good evidence, both in vitro and in vivo, that ethanol increases production and circulating levels of HDL-Cholesterol, and reduces clot formation by blocking thrombin activity as well as by inhibition of fibrinolysis. It also prevents migration of smooth-muscle cells to the intimal layer of arteries and reduces the incidence of Type II Diabetes Mellitus, a major risk factor for atherosclerotic disease. Red wine, in addition to ethanol, contains many polyphenolic antioxidants that are also present in fruit and vegetables (such as catechin and quercetin), as well as resveratrol that is almost restricted to grapes and red w...

show abstract

“…Proposed mechanisms include an increased supply of lipids, lipoprotein particles, and apolipoproteins (apo) by the liver, and in the long term, an enhanced synthesis of nascent HDL particles (Amarasuriya et al, 1992;Rakic et al, 1998). Another discussed mechanism focusses on an enhanced lipolysis of triglyceride-rich lipoprotein particles, for instance by an alteration in the activity of lipoprotein lipase, cholesterol ester transfer protein, hepatic lipase, and lecithin:cholesterol acyltransferase, although not confirmed by all studies (Hannuksela et al, 1992;Välimäki et al, 1993;Nishiwaki et al, 1994).…”

Section: Alcohol and Risk Factors Of Cardiovascular Disease M Burger mentioning

confidence: 99%

Alcohol consumption and its relation to cardiovascular risk factors in Germany

Burger

Mensink

Brönstrup³

et al. 2004

Eur J Clin Nutr

View full text Add to dashboard Cite

Objective: To analyse the association of alcohol consumption and blood lipids, haemostatic factors, and homocysteine in German adults by gender and age groups. Design: Cross-sectional population-based survey. Setting: Data from the German National Health Interview and Examination Survey 1998, representative for age, gender, community size, and federal state. Subjects: From a sample of 7124 Germans between 18 and 79 y old, 2420 women and 2365 men were selected. Only individuals who were not currently receiving medical treatment or did not have disorders related to cardiovascular disease were selected for this study. Results: Using analyses of variance, mean blood levels of total cholesterol, HDL cholesterol, HDL/total cholesterol ratio, total glycerides, fibrinogen, antithrombin III, and homocysteine adjusted for age, socioeconomic status, East/West Germany residence, body mass index, tobacco use, sports activity, and coffee consumption, if appropriate are presented by alcohol consumption groups (0, 40-10, 410-20, 420-30 and 430 g/day). The HDL/total cholesterol ratio increased with higher alcohol groups up to 10-20 g/day ( þ 15%) for women and 430 g/day ( þ 18%) for men, showing the strongest rise among men aged 55-79 y. Fibrinogen decreased with higher alcohol groups up to 10-20 g/day for women and 20-30 g/day for men. Among women, homocysteine levels showed a U-shaped curve with a minimum of 8.49 mmol/l at 10-20 g alcohol/day (À8%, reference: nondrinking), whereas an inverse association was observed for men. Conclusions: Moderate alcohol consumption is associated with favourable levels of several cardiovascular risk factors. The most favourable cardiovascular risk factor profile among women was observed among those drinking 10-20 g alcohol/day. Beneficial effects seem to be more pronounced among older men.

show abstract

Ethanol stimulates apolipoprotein A-I secretion by human hepatocytes: Implications for a mechanism for atherosclerosis protection

Cited by 60 publications

References 42 publications

Effect of Alcohol on Lipids and Lipoproteins in Relation to Atherosclerosis

Effect of Alcohol on Lipids and Lipoproteins in Relation to Atherosclerosis

Wine and Health: A Paradigm for Alcohol and Antioxidants

Alcohol consumption and its relation to cardiovascular risk factors in Germany

Contact Info

Product

Resources

About