“…Dentin dehydration occurs with application of increasing concentrations of ethanol solutions, allowing the subsequent infiltration of a hydrophobic primer followed by a hydrophobic adhesive resin (3,6). This hybrid layer is less hydrophilic and more resistant to overtime hydrolytic degradation caused by the endogenous enzymes, such as metalloproteinases (MMPs), due to a more effective collagen protection (19,20) and prevention of phase separation (8,18,21,22). Some laboratory studies demonstrated higher adhesive interface bond strengths when ethanol solutions were used to dehydrate dentin prior to primer and adhesive application, compared with the strengths achieved using conventional adhesive techniques (4,7,18,21).…”