Ethanol, Wine, and Experimental Cardioprotection in Ischemia/Reperfusion: Role of the Prooxidant/Antioxidant Balance

Rakotovao, Andry; Berthonneche, Corinne; Guiraud, Annabelle; Lorgeril, Michel de; Salen, Patricia; Leiris, Joël de; Boucher, François

doi:10.1089/152308604322899503

Cited by 25 publications

(16 citation statements)

References 70 publications

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“…Red wine polyphenols exhibit antioxidant, vasorelaxant, and antithrombotic properties (Opie and Lecour 2007). Red wine polyphenols that have been implicated in protection against myocardial ischemic reperfusion injury in animal models include resveratrol and proanthocyanidins (Das et al 1999, Rakotovao et al 2004, Opie and Lecour 2007. There is evidence that white wine may also be cardioprotective due to alcohol and antioxidant (caffeic acid, tyrosol, and hydroxytyrosol) components (Bertelli 2007).…”

Section: Dose/effect a Finding Referencementioning

confidence: 99%

Wine and Health: A Review

Guilford

Pezzuto

2011

Am. J. Enol. Vitic.

168

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Abstract:As indicated by epidemiological studies, regular and moderate wine consumption, particularly red wine, has been associated with health benefits. Clinical studies and work performed with animal models indicate that wine may protect against cardiovascular disease, atherosclerosis, hypertension, certain types of cancer, type 2 diabetes, neurological disorders, and metabolic syndrome. The mechanism of action has been attributed to antioxidant, lipid regulating, and anti-inflammatory effects. A variety of wine constituents have been studied in various disease models. Both the alcoholic and polyphenolic components of wine are believed to contribute to these beneficial effects. As wine is a complex mixture, it is likely that a multitude of chemical constituents, as well as their metabolites, work synergistically to impact human health. In sum, although wine drinking may be contraindicated in certain individuals, in healthy people, regular consumption of moderate amounts of wine may protect against certain chronic health conditions.

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Section: Dose/effect a Finding Referencementioning

confidence: 99%

Wine and Health: A Review

Guilford

Pezzuto

2011

Am. J. Enol. Vitic.

168

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“…The results of a large number of epidemiologic studies indicate that consumption of red wine at low to moderate levels is cardioprotective, reducing the incidence and severity of myocardial infarction and stroke (1)(2)(3). Studies conducted in cultured cell and intact animal models attributed these beneficial effects to the polyphenolic antioxidants present in red wine (4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Ethanol preconditioning protects against ischemia/reperfusion-induced brain damage: Role of NADPH oxidase-derived ROS

Wang

Sun

Simonyi

et al. 2007

Free Radical Biology and Medicine

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Ethanol preconditioning (EtOH-PC) refers to a phenomenon in which tissues are protected from the deleterious effects of ischemia/reperfusion (I/R) by prior ingestion of ethanol at low to moderate levels. In this study, we tested whether prior (24 hrs) administration of ethanol as a single bolus that produced a peak plasma concentration of 42-46 mg/dl in gerbils would offer protective effects on neuronal damage due to cerebral I/R. In addition, we also tested whether reactive oxygen species (ROS)-derived from NADPH oxidase played a role as an initiator of these putative protective effects. Groups of gerbils were administered either ethanol or the same volume of water by gavage 24 hrs prior to transient global cerebral ischemia induced by occlusion of both common carotid arteries (CCA) for 5 min. In some experiments, apocynin, a specific inhibitor of NADPH oxidase, was administered (5 mg/kg body wt, i.p.) 10 min before ethanol administration. EtOH-PC ameliorated behavioral deficit induced by cerebral I/R and protected the brain against I/R-induced delayed neuronal death (DND), neuronal and dendritic degeneration, oxidative DNA damage, and glial cell activation. These beneficial effects were attenuated by apocynin treatment coincident with ethanol administration. Ethanol ingestion was associated with translocation of the NADPH oxidase subunit, p67 phox , from hippocampal cytosol fraction to membrane, increased NADPH oxidase activity in hippocampus within the first hour after gavage, and increased lipid peroxidation (4-hydroxy-2-nonenal, HNE) in plasma and hippocampus within the first 2 hrs after gavage. These effects were also inhibited by concomitant apocynin treatment. Our data are consistent with the hypothesis that antecedent ethanol ingestion at socially-relevant levels induces neuroprotective effects in I/R by a mechanism that is triggered by ROS produced through NADPH oxidase. Our results further suggest the possibility that preconditioning with other pharmacological agents that induce a mild oxidative stress may have similar therapeutic value for suppressing stroke-mediated damage in brain.

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“…Epidemiological studies suggested that red wine consumption is associated with a reduction of mortality and morbidity from ischemic heart disease, but there is no direct evidence to support wine as antiarrhythmic [6,11,15,16,18]. The antiarrhythmic mechanisms of natural drugs are usually deductions based on physiopathological reasoning, in vitro determinations and theoretical conclusions [38].…”

Section: Discussionmentioning

confidence: 99%

“…Antioxidants are potential therapeutic strategies against cardiovascular diseases, including reperfusion injury [6][7][8][9]. Particularly, wine attracted much attention as cardioprotective due to the so-called French paradox [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…Particularly, wine attracted much attention as cardioprotective due to the so-called French paradox [10][11][12]. Prospective studies suggest that wine is more protective against cardiovascular diseases than other alcoholic beverages like beer or liqueur [6,13,14]. Alcohol addictive properties and the damage associated with abuse make the wine difficult to recommend [15].…”

Section: Introductionmentioning

confidence: 99%

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Antiarrhythmic mechanisms of Malbec wine and resveratrol in isolated rat heart

Nj¹,

Dj²,

Parra³

et al. 2017

Cardiovasc Disord Med

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Oxidative stress during myocardial reperfusion contributes to ventricular arrhythmias onset. We aim to evaluate the antiarrhythmic effect of Malbec wine and resveratrol and compare them with the synthetic antioxidant tiron. Since alcohol use is controversial, we also assessed dealcoholized wine.Isolated hearts from male Sprague Dawley rats were perfused with Krebs-Henseleit solution added with: Malbec wine (5 ml/L), resveratrol (10 μM,) compared to controls with alcohol (0.5 ml/L); dealcoholized wine (5 ml/L), tiron (10 mM) were compared with controls without alcohol. Epicardial action potentials were analyzed during basal state, regional ischemia and reperfusion (10 minutes each period). The incidence of arrhythmias was determined. The antioxidant effect was assessed in left ventricle homogenates and expressed as a percentage of inhibition of the ABTS•+ radical.Malbec wine and resveratrol reduced reperfusion arrhythmias in 56% and 50%, respectively, compared to 100% incidence in the control group with alcohol.Dealcoholized wine reduced arrhythmias to 50% compared to non-alcoholic control (90.5%), but tiron did not protect (69%). The free radicals inhibitory effect increased with all the compounds (resveratrol 54.2%, tiron 43.2%, Malbec wine 42.9%, dealcoholized wine 40.2%) with respect to the control groups (with alcohol 23.5%, without alcohol 21.2%). Resveratrol shortened action potential duration and prevented ischemic depolarization. Malbec prevented ischemic-induced action potential shortening.We conclude that Malbec wine and resveratrol are antiarrhythmic beyond their antioxidant properties. Alcohol content or was not essential. Protection from ischemic action potential changes could be relevant to the antiarrhythmic effect of both resveratrol and wine.

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Ethanol, Wine, and Experimental Cardioprotection in Ischemia/Reperfusion: Role of the Prooxidant/Antioxidant Balance

Cited by 25 publications

References 70 publications

Wine and Health: A Review

Wine and Health: A Review

Ethanol preconditioning protects against ischemia/reperfusion-induced brain damage: Role of NADPH oxidase-derived ROS

Antiarrhythmic mechanisms of Malbec wine and resveratrol in isolated rat heart

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