Ethanolic extract of Boswellia ovalifoliolata bark and leaf attenuates doxorubicin-induced cardiotoxicity in mice

Mahesh, B.; Shrivastava, Shweta; Madhusudhana, K.; Sahu, Bidya Dhar; Challa, Veerabhadra Swamy; Pragada, Rajeswara Rao; Naidu, V.G.M.; Sistla, Ramakrishna

doi:10.1016/j.etap.2013.07.016

Cited by 19 publications

(4 citation statements)

References 22 publications

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“…Our results revealed that the ST and QT intervals were significantly extended in mice exposed to free DOX in comparison with those in the control group. Several studies have shown a positive association between DOX cardiotoxicity and QT and ST-interval duration [27][28][29]. ST-interval elongation in DOX-injected mice is due to an increase in action potential duration [30].…”

Section: Ast (U/l) Alt (U/l) Ldh (U/l) Ck-mb (U/l)mentioning

confidence: 99%

The Comparison of Biodistribution, Efficacy and Toxicity of Two PEGylated Liposomal Doxorubicin Formulations in Mice Bearing C-26 Colon Carcinoma: a Preclinical Study

et al. 2016

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Section: Ast (U/l) Alt (U/l) Ldh (U/l) Ck-mb (U/l)mentioning

confidence: 99%

The Comparison of Biodistribution, Efficacy and Toxicity of Two PEGylated Liposomal Doxorubicin Formulations in Mice Bearing C-26 Colon Carcinoma: a Preclinical Study

et al. 2016

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“…Previous investigators predominantly use alcoholic extractions to evaluate the biological activity of Boswellia oleoresins ( Uma Mahesh et al, 2013 ; Ahmed et al, 2015 ; Zhang et al, 2016 ; Alipanah and Zareian, 2018 ). However, it wasn’t clear if alcoholic solvents are optimal given that no previous studies have directly compared the extraction yield and biological activity of alternative solvent extracts.…”

Section: Discussionmentioning

confidence: 99%

Boswellia carterii oleoresin extracts induce caspase-mediated apoptosis and G1 cell cycle arrest in human leukaemia subtypes

Jones,

Borun,

Greensmith

2023

Front. Pharmacol.

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Background: Leukemias are a common cancer in adults and children. While existing treatments are effective, they are associated with severe side-effects compounded by the emergence of drug resistance. This necessitates the need to develop new drugs and phytopharmaceuticals offer a largely untapped source. Oleoresins produced by plants in the genus Boswellia have been used for centuries in traditional medicine and recent work suggests they may exhibit anti-cancer activity. However, the underlying mechanisms remain unclear and most existing research focusses on Boswellia serrata; just one of many species in the Boswellia genus. To address these limitations, we elucidated the anti-cancer potential and associated mechanisms of action of Boswellia carterii.Methods: A methanolic solvent extraction method was optimised. The effect of methanolic extracts of B. carterii on leukaemia (K562, MOLT-4 and CCRF-CEM) and normal (PBMC) cell line viability was assessed using MTT assay and flow cytometry. Cell morphology, apoptosis (Annexin-V/propidium iodide), mitochondrial membrane potential (Rhodamine-123) and the cell cycle (propidium iodide) were evaluated using flow cytometry. Regulatory protein expression was quantified using Western Blot.Results: Methanolic extracts of B. carterii oleoresin reduced the viability of K562, MOLT-4 and CCRF-CEM cell lines with selectivity indexes of between 1.75 and 2.68. Extracts increased the proportion of cells in late apoptosis by 285.4% ± 51.6%. Mitochondrial membrane potential was decreased by 41% ± 2% and the expression of cleaved caspase-3, -7, and -9 was increased by 5.7, 3.3, and 1.5-fold respectively. Extracts increased the proportion of cells in subG1 and G1 phase by 867.8% ± 122.9% and 14.0 ± 5.5 and decreased those in S phase and G2/M by 63.4% ± 2.0% and 57.6% ± 5.3%. Expression of CDK2, CDK6, cyclin D1, and cyclin D3 were decreased by 2.8, 4.9, 3.9, and 2.5-fold.Conclusion: We are the first to report that methanolic extracts of B. carterii are selectively cytotoxic against three leukemia cell lines. Cytotoxic mechanisms likely include activation of the intrinsic apoptotic pathway and cell cycle arrest through downregulation of CDK2, CDK6, cyclin D1, and cyclin D3. Our findings suggest that B. carterii may be an important source of novel chemotherapeutic drugs and justifies further investigation.

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“…The elemental composition of ZnO nanoparticle obtained from EDAX analysis (Figure 4c) was Zinc (48.52%), Oxygen The strong emission of nanoparticle in aqueous solution encouraged us to explore their possible application as chemosensor for the detection of nitroaromatic compounds such as picric acid (PA), dinitrotoluene (DNT), nitrobenzene (NB), nitrophenol (NP), 4-nitrobenzaldehyde (BAO), dinitrobenzene (BNB), dinitrophenol (DNP), 4-nitrobenzoic acid (NBA) and nitrotoluene (NT). The detection of nitroaromatic compounds has attracted many researchers to fight against terrorism and environmental impact 26 . A number of techniques used for the detection of nitroaromatic compounds, but fluorescence-based detection offers many advantages like high sensitivity, short response time and specificity 1 .…”

Section: Scanning Electron Microscopy (Sem)mentioning

confidence: 99%

“…Different methods have been employed for the detection of NACs such as ionic liquids, X-ray diffraction, organic gels, neutron activation, Raman spectroscopy, electrochemical, metal-organic frameworks, nanoparticle, polymers, quantum dots, ion mobility in solution and vapor phase which are high cost effective and are not easily accessible 5,6,12 . Hence, fluorescence quenching based sensing is widely used and proven to be highly sensitive 6 , selective 26 , fast, low cost 1 , and simple instrumentation 6 .…”

Section: Introductionmentioning

confidence: 99%

Fluorescent zinc oxide nanoparticles of Boswellia ovalifoliolata for selective detection of picric acid

et al. 2019

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The use of Boswellia ovalifoliolata bark extract for the synthesis of zinc oxide nanoparticles (ZnO NPs) with benefits of eco-friendliness, low cost and compatibility for pharmaceutical and biological applications. In this paper, we report the biosynthesis of zinc oxide nanoparticles using plant extract and its application for the detection of picric acid (PA). The synthesized ZnO nanoparticles were characterized using UV-Vis spectroscopy, scanning electron microscopy (SEM), X-ray diffraction pattern (XRD), fourier transform infrared spectroscopy (FT-IR) and fluorescene spectroscopy. ZnO NPs in aqueous solution shows maximum absorption bands at 278 nm and fluorescence emission at 317 nm. The fluorescence emission of zinc oxide nanoparticle shows high selectivity towards picric acid (PA) and can be used as a fluorescent probe for the detection of PA via fluorescence quenching mechanism. The fluorescence quenching mechanism of picric acid may be due to the electron transfer process between ZnO NPs and picric acid which is confirmed by cyclic voltammetry (CV). The quenching efficiency of nanoparticle was calculated using Stern-Volmer equation. The limit of detection was found to be 1.83 µM for picric acid. The fluorescence property of the ZnO NPs can be utilized for cell imaging application as biosensors and also in the field of drug delivery.

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Ethanolic extract of Boswellia ovalifoliolata bark and leaf attenuates doxorubicin-induced cardiotoxicity in mice

Cited by 19 publications

References 22 publications

The Comparison of Biodistribution, Efficacy and Toxicity of Two PEGylated Liposomal Doxorubicin Formulations in Mice Bearing C-26 Colon Carcinoma: a Preclinical Study

The Comparison of Biodistribution, Efficacy and Toxicity of Two PEGylated Liposomal Doxorubicin Formulations in Mice Bearing C-26 Colon Carcinoma: a Preclinical Study

Boswellia carterii oleoresin extracts induce caspase-mediated apoptosis and G1 cell cycle arrest in human leukaemia subtypes

Fluorescent zinc oxide nanoparticles of Boswellia ovalifoliolata for selective detection of picric acid

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