Ethanolic Extract of Butea monosperma Leaves Elevate Blood Insulin Level in Type 2 Diabetic Rats, Stimulate Insulin Secretion in Isolated Rat Islets, and Enhance Hepatic Glycogen Formation

Abstract

We measured a vast range of parameters, in an attempt to further elucidate previously claimed antihyperglycemic activity of Butea monosperma. Our study clearly negates the possibility of antidiabetic activity by inhibited gastrointestinal enzyme action or by reduced glucose absorption. Reduction of fasting and postprandial glucose level was reconfirmed (P < 0.05). Improved serum lipid profile via reduced low density lipoprotein (LDL), cholesterol, triglycerides (TG), and increased high density lipoprotein (HDL) was also reestablished (P < 0.05). Significant insulin secretagogue activity of B. monosperma was found in serum insulin assay of B. monosperma treated type 2 diabetic rats (P < 0.01). This was further ascertained by our study on insulin secretion on isolated rat islets (P < 0.05). Improved sensitivity of glucose was shown by the significant increase in hepatic glycogen deposition (P < 0.05). Hence, we concluded that antihyperglycemic activity of B. monosperma was mediated by enhanced insulin secretion and enhanced glycogen formation in the liver.

Review on Medicinal Importance of Butea monosperma Lam. (Taub)

“…The interesting fact of the investigation is the formation of hepatic glycogen and secretion of insulin in isolated rats. 17 The powder of Dhak fruits was administered orally at various dosages in usual and diabetic subjects and it not only shows a noteworthy decrease in blood glucose, LDL cholesterol, urine sugar, and total lipids but also showed an upsurge in HDL cholesterol. 18 In a study, methanolic excerpts of Dhak fruits at the dose of 3 gm/30 ml of water for 30 days have shown a reduction in blood urine sugar, glucose levels, and plasma glycoprotein.…”