Ethanolic Extract of<i>Vitis thunbergii</i>Exhibits Lipid Lowering Properties via Modulation of the AMPK-ACC Pathway in Hypercholesterolemic Rabbits

Pan, Chun Hsu; Tsai, Chia Hua; Lin, Wen-Hsin; Chen, Guo Yan; Wu, Chieh Hsi

doi:10.1155/2012/436786

Cited by 16 publications

(22 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In total, 1 × DSW, and 2 × DSW significantly improved the TC level by 1.18-, and 1.21-fold, respectively. The results have been consistent with findings in other studies [28,29], and the results were similar to the effects in the MgCl 2 and lovastatin groups (Figure 1a).…”

Section: Resultssupporting

confidence: 93%

See 1 more Smart Citation

Deep Sea Water Modulates Blood Pressure and Exhibits Hypolipidemic Effects via the AMPK-ACC Pathway: An in Vivo Study

et al. 2013

Self Cite

View full text Add to dashboard Cite

Deep sea water (DSW), originally pumped from the Pacific Rim off the coast of Hualien County (Taiwan), and its mineral constituents, were concentrated by a low-temperature vacuum evaporation system to produce a hardness of approximately 400,000 mg/L of seawater mineral concentrate. The primary composition of this seawater mineral concentrate was ionic magnesium (Mg2+), which was approximately 96,000 mg/L. Referring to the human recommended daily allowance (RDA) of magnesium, we diluted the mineral concentrate to three different dosages: 0.1 × DSW (equivalent to 3.75 mg Mg2+/kg DSW); 1 × DSW (equivalent to 37.5 mg Mg2+/kg DSW); and 2 × DSW (equivalent to 75 mg Mg2+/kg DSW). Additionally, a magnesium chloride treatment was conducted for comparison with the DSW supplement. The study indicated that 0.1 × DSW, 1 × DSW and 2 × DSW decreased the systolic and diastolic pressures in spontaneous hypertensive rats in an eight-week experiment. DSW has been shown to reduce serum lipids and prevent atherogenesis in a hypercholesterolemic rabbit model. Our results demonstrated that 1 × DSW and 2 × DSW significantly suppressed the serum cholesterol levels, reduced the lipid accumulation in liver tissues, and limited aortic fatty streaks. These findings indicated that the antiatherogenic effects of DSW are associated with 5′-adenosine monophosphate-activated protein kinase (AMPK) stimulation and the consequent inhibition of phosphorylation of acetyl-CoA carboxylase (ACC) in atherosclerotic rabbits. We hypothesize that DSW could potentially be used as drinking water because it modulates blood pressure, reduces lipids, and prevents atherogenesis.

show abstract

Section: Resultssupporting

confidence: 93%

“…Previously, Pan et al reported the methods for the quantification of atherosclerotic lesions in the aortic root [29]. To determine the effect of DSW on the fatty streak formation, six-week-old male New Zealand white rabbits were fed with the 0.5% cholesterol diet for eight weeks.…”

Section: Resultsmentioning

confidence: 99%

Deep Sea Water Modulates Blood Pressure and Exhibits Hypolipidemic Effects via the AMPK-ACC Pathway: An in Vivo Study

et al. 2013

Self Cite

View full text Add to dashboard Cite

show abstract

“…Composition analysis revealed that the dry root of V. thunbergii contained several kinds of polyphenols. Moreover, Pan et al [12] reported that ethanolic extract of V. thunbergii exhibited lipid lowering properties possibly by the activation of 5 -adenosine monophosphate-activated protein kinase (AMPK). Since AMPK is a critical regulator of glucose and lipid metabolism, our results and relevant findings suggest that the events of hypoglycemic and hypolipidemic effects might be pharmacological targets of polyphenolic compounds in ethanolic extract of V. thunbergii roots and the AMPK signaling pathway is a potential linking bridge.…”

Section: Discussionmentioning

confidence: 99%

“…The root of it has widely been used as folk medicine for treating fracture and injury, diarrhea, hepatitis and arthritis in Taiwan [8]. Recent studies have also indicated that it possesses a variety of efficacies such as antiplatelet [9], antimicrobial [10], antihypertensive [2], neuroprotective [11], and lipid-lowering [12] effect. These multiple health-promoting effects underscore the need to further investigate its action characteristics.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Vitis thunbergii supplementation demonstrates an anti-obesity effect in developing obese mice

Hsu

Chen

Pan

et al. 2014

European Journal of Integrative Medicine

View full text Add to dashboard Cite

Perfluorooctane sulfonate promotes hepatic lipid accumulation and steatosis in high‐fat diet mice through AMP‐activated protein kinase/acetyl‐CoA carboxylase (AMPK/ACC) pathway

Ling

Hua

Qin

et al. 2022

J of Applied Toxicology

View full text Add to dashboard Cite

Perfluorooctane sulfonate (PFOS) is a hepatotoxic environmental organic pollutant that can cause aberrant lipid accumulation in the liver. However, the molecular mechanism underlying PFOS‐induced hepatic steatosis remains unclear. Our research showed that subchronic PFOS exposure inhibited AMP‐activated protein kinase (AMPK) phosphorylation, leading to increased acetyl‐CoA carboxylase (ACC) activity, attenuated fatty acid β‐oxidation, and consequent liver lipid accumulation. We found that 1 mg/kg/day PFOS exposure significantly aggravated steatosis in high‐fat diet (HFD)‐fed mice, along with reduced AMPK activity. Oil Red O results showed that PFOS exposure caused fat accumulation in HepG2 cells. As predicted, PFOS treatment reduced the level of phosphorylated AMPK in a concentration‐dependent manner, leading to subsequent increase in ACC activity and lipid droplet accumulation in HepG2 cells. Treatment with 200‐μM AMPK agonist AICAR alleviated PFOS‐induced ACC activation and lipid accumulation. In summary, our data highlight a crucial role of AMPK/ACC pathway in PFOS‐mediated liver lipid metabolic disorders.

show abstract

Ethanolic Extract ofVitis thunbergiiExhibits Lipid Lowering Properties via Modulation of the AMPK-ACC Pathway in Hypercholesterolemic Rabbits

Cited by 16 publications

References 54 publications

Deep Sea Water Modulates Blood Pressure and Exhibits Hypolipidemic Effects via the AMPK-ACC Pathway: An in Vivo Study

Deep Sea Water Modulates Blood Pressure and Exhibits Hypolipidemic Effects via the AMPK-ACC Pathway: An in Vivo Study

Vitis thunbergii supplementation demonstrates an anti-obesity effect in developing obese mice

Perfluorooctane sulfonate promotes hepatic lipid accumulation and steatosis in high‐fat diet mice through AMP‐activated protein kinase/acetyl‐CoA carboxylase (AMPK/ACC) pathway

Contact Info

Product

Resources

About