Ethanolic extract of Pyrus pashia buch ham ex. D. Don (Kainth): A bioaccessible source of polyphenols with anti-inflammatory activity in vitro and in vivo

Prakash, Om; Gopinath, Madhumala; Kumar, Prashant; Kumar, Shiv; Kudachikar, V. B.

doi:10.1016/j.jep.2021.114628

Cited by 10 publications

(2 citation statements)

References 38 publications

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“…The biomolecules obtained from pear and its extracts has also many cardioprotective functions. The extracts of Pyrus , commonly known as Himalayan pear have rich content of arbutin, catechin, and chlorogenic acid and were known to inhibit the COX-2 activities and reduce IL-6 and TNF-α expression in LPS-stimulated RAW macrophages ( Figure 2 ; Om et al, 2022 ). The arbutin treatment could also protect against LPS-induced myocardial injury via ER pathway in an in vivo model system through the modulation of TNF-α and IL-6 levels ( Zhang et al, 2019 ).…”

Section: Management Of Cardiovascular Diseases and Blood Lipid Profilementioning

confidence: 99%

Fruit waste: a current perspective for the sustainable production of pharmacological, nutraceutical, and bioactive resources

Sha,

Modak,

Sarkar

et al. 2023

Front. Microbiol.

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Fruits are crucial components of a balanced diet and a good source of natural antioxidants, that have proven efficacy in various chronic illnesses. Various kinds of waste generated from fruit industries are considered a global concern. By utilizing this fruit waste, the international goal of “zero waste” can be achieved by sustainable utilization of these waste materials as a rich source of secondary metabolites. Moreover, to overcome this waste burden, research have focused on recovering the bioactive compounds from fruit industries and obtaining a new strategy to combat certain chronic diseases. The separation of high-value substances from fruit waste, including phytochemicals, dietary fibers, and polysaccharides which can then be used as functional ingredients for long-term health benefits. Several novel extraction technologies like ultrasound-assisted extraction (UAE), pressurized liquid extraction (PLE), and supercritical fluid extraction (SFE) could provide an alternative approach for successful extraction of the valuable bioactives from the fruit waste for their utilization as nutraceuticals, therapeutics, and value-added products. Most of these waste-derived secondary metabolites comprise polyphenols, which have been reported to have anti-inflammatory, insulin resistance-treating, cardiovascular disease-maintaining, probiotics-enhancing, or even anti-microbial and anti-viral capabilities. This review summarizes the current knowledge of fruit waste by-products in pharmacological, biological, and probiotic applications and highlights several methods for identifying efficacious bioactive compounds from fruit wastes.

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Section: Management Of Cardiovascular Diseases and Blood Lipid Profilementioning

confidence: 99%

Fruit waste: a current perspective for the sustainable production of pharmacological, nutraceutical, and bioactive resources

Sha,

Modak,

Sarkar

et al. 2023

Front. Microbiol.

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“…Pyrus pashia, known as the Himalayan pear, extracts, rich in chlorogenic acid, catechin, epicatechin, and arbutin, inhibited 5-lipoxygenase, cyclooxygenase-2 activities and reduced IL-6 and TNF-α expression in vitro. Moreover, these extracts demonstrated similar anti-inflammatory properties in an in vivo mouse model [ 126 ]. Oleanolic acid, a pentacyclic triterpenoid detected in pear peels, is known to exhibit anti-inflammatory properties.…”

Section: Pearmentioning

confidence: 99%

Agri-Food Waste from Apple, Pear, and Sugar Beet as a Source of Protective Bioactive Molecules for Endothelial Dysfunction and Its Major Complications

et al. 2022

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Endothelial damage is recognized as the initial step that precedes several cardiovascular diseases (CVD), such as atherosclerosis, hypertension, and coronary artery disease. It has been demonstrated that the best treatment for CVD is prevention, and, in the frame of a healthy lifestyle, the consumption of vegetables, rich in bioactive molecules, appears effective at reducing the risk of CVD. In this context, the large amount of agri-food industry waste, considered a global problem due to its environmental and economic impact, represents an unexplored source of bioactive compounds. This review provides a summary regarding the possible exploitation of waste or by-products derived by the processing of three traditional Italian crops—apple, pear, and sugar beet—as a source of bioactive molecules to protect endothelial function. Particular attention has been given to the bioactive chemical profile of these pomaces and their efficacy in various pathological conditions related to endothelial dysfunction. The waste matrices of apple, pear, and sugar beet crops can represent promising starting material for producing “upcycled” products with functional applications, such as the prevention of endothelial dysfunction linked to cardiovascular diseases.

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Coffee leaf polyphenol-rich extracts alleviated lipopolysaccharide-induced intestinal barrier dysfunction: Insights from a Caco-2/U937 co-culture model

Mei,

Kitts,

Chen

2024

Food Bioscience

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Ethanolic extract of Pyrus pashia buch ham ex. D. Don (Kainth): A bioaccessible source of polyphenols with anti-inflammatory activity in vitro and in vivo

Cited by 10 publications

References 38 publications

Fruit waste: a current perspective for the sustainable production of pharmacological, nutraceutical, and bioactive resources

Fruit waste: a current perspective for the sustainable production of pharmacological, nutraceutical, and bioactive resources

Agri-Food Waste from Apple, Pear, and Sugar Beet as a Source of Protective Bioactive Molecules for Endothelial Dysfunction and Its Major Complications

Coffee leaf polyphenol-rich extracts alleviated lipopolysaccharide-induced intestinal barrier dysfunction: Insights from a Caco-2/U937 co-culture model

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