Ethanolic Fenugreek Extract: Its Molecular Mechanisms against Skin Aging and the Enhanced Functions by Nanoencapsulation

Eaknai, Waleewan; Bunwatcharaphansakun, Phichaporn; Phungbun, Chutikorn; Jantimaporn, Angkana; Chaisri, Sasikan; Boonrungsiman, Suwimon; Nimmannit, Ubonthip; Khongkow, Mattaka

doi:10.3390/ph15020254

Cited by 8 publications

(10 citation statements)

References 62 publications

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“…To monitor the damaging effect caused by UV radiation, the decreased cell viability and the increased levels of proinflammatory cytokines, including IL-6 and IL-8, were shown. The free radical formation and the activation of inflammatory response are associated with the decreased viability of co-HaHF [14]. Interestingly, the protective effect of RBS and RBH after UV radiation in co-HaHF was revealed and was in agreement with the cellular protection in antioxidant activity assay in HF.…”

Section: Discussionsupporting

confidence: 66%

“…For cytotoxicity assay in single cells used for construction of co‐HaHF, HaCaT cells and HF were performed by MTT assay [14]. The co‐HaHF was constructed as shown in Figure S1 (Data S5) [14].…”

Section: Methodsmentioning

confidence: 99%

“…For cytotoxicity assay in single cells used for construction of co-HaHF, HaCaT cells and HF were performed by MTT assay [14]. The co-HaHF was constructed as shown in Figure S1 (Data S5) [14]. HF (8.5 × 10 4 cells/well) was seeded into 12-well insert culture plate (Corning, USA) and cultured for 24 h. The second and third layers of HF were added on consecutive days.…”

Section: Cytotoxicity Assaymentioning

confidence: 99%

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Anti‐skin ageing activities of rice (Oryza sativa) bran soft and hard waxes in cultured skin cells

Chaikul,

Kanlayavattanakul,

Khongkow

et al. 2023

Intern J of Cosmetic Sci

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ObjectiveRice (Oryza sativa) bran waxes, the by‐products of rice bran oil manufacturing, are widely used as inactive components in several preparations. Nevertheless, the function of rice bran waxes against skin aging has never been reported. This study aimed to investigate thermal property and fatty acid profile of rice bran waxes, including rice bran soft (RBS) and hard (RBH) waxes, and the activities against skin aging in cultured skin cells.MethodsThermal property and fatty acid profile of rice bran waxes were analyzed by differential scanning calorimetry and gas chromatography‐mass spectrometry, respectively. The cytotoxicity assay of waxes was performed in B16F10 melanoma cells, human skin fibroblasts, and co‐culture cells of HaCaT cells and human skin fibroblasts. The non‐cytotoxic concentrations of waxes were evaluated for their activities against skin aging, including melanogenesis assay, antioxidant activity, collagen content analysis, matrix metalloproteinase‐1 and matrix metalloproteinase‐2 inhibitory assay, and anti‐inflammatory activity.ResultsThermal property indicated the endotherm peaks with melting temperatures at 40.89 ± 0.27°C and 69.64 ± 0.34°C for RBS and RBH, respectively. The main fatty acids in RBS were oleic (31.68 ± 0.75%) and linoleic acids (27.19 ± 0.40%), whereas those in RBH were palmitic (36.24 ± 1.08%) and stearic acids (35.21 ± 4.51%). The cytotoxicity assay in single cells and co‐culture cells showed the non‐cytotoxicity of RBS (0.0001 ‐ 1 mg/mL) and RBH (0.0001 ‐ 0.1 mg/mL). The anti‐skin aging activities of 1 mg/mL RBS and 0.1 mg/mL RBH included the melanogenesis inhibition by suppression of tyrosinase and tyrosinase‐related protein‐2 enzymes, the antioxidant activity by cellular protection against cell damage and cell death, the collagen stimulation, the matrix metalloproteinase‐1 and matrix metalloproteinase‐2 suppression, and the anti‐inflammation.ConclusionsThe study results suggest that RBS and RBH can potentially be applied as the functional ingredients in formulations against skin aging as well as provide the superior benefit on skin moisturization.

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Section: Discussionsupporting

confidence: 66%

Section: Methodsmentioning

confidence: 99%

Section: Cytotoxicity Assaymentioning

confidence: 99%

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Anti‐skin ageing activities of rice (Oryza sativa) bran soft and hard waxes in cultured skin cells

Chaikul,

Kanlayavattanakul,

Khongkow

et al. 2023

Intern J of Cosmetic Sci

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“…The cell viability was measured by the MTT assay [ 30 ]. An MTT solution (1 mg/mL) was added to each well and incubated for 4 h at 37 °C.…”

Section: Methodsmentioning

confidence: 99%

Eight Indole Alkaloids from the Roots of Maerua siamensis and Their Nitric Oxide Inhibitory Effects

et al. 2022

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Maerua siamensis (Capparaceae) roots are used for treating pain and inflammation in traditional Thai medicine. Eight new indole alkaloids, named maeruanitriles A and B, maeroximes A–C, and maeruabisindoles A–C, were isolated from them. Spectroscopic methods and computational analysis were applied to determine the structure of the isolated compounds. Maeroximes A–C possesses an unusual O-methyloxime moiety. The bisindole alkaloid maeruabisindoles A and B possess a rare azete ring, whereas maeruabisindole C is the first indolo[3,2-b]carbazole derivative found in this plant family. Five compounds [maeruanitriles A and B, maeroxime C, maeruabisindoles B, and C] displayed anti-inflammatory activity by inhibiting nitric oxide (NO) production in the lipopolysaccharide-induced RAW 264.7 cells. Maeruabisindole B was the most active inhibitor of NO production, with an IC50 of 31.1 ± 1.8 μM compared to indomethacin (IC50 = 150.0 ± 16.0 μM) as the positive control.

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“…Conversely, methanol extract of Amygdalus communis exhibited weak inhibition toward tyrosinase (Tlili et al., 2019). A study on anti‐elastase property of Alkanna tinctoria revealed that acetone extract possessed the best activity with IC 50 10.02 µg/mL (Jaradat et al., 2018), whereas ethanol extract of Trigonella foenum‐graecum seed exhibited moderate inhibition of collagenase activity (IC 50 : 560 µg/mL) (Eaknai et al., 2022).…”

Section: Experimental Models Of Agingmentioning

confidence: 99%

Medicinal foods and plants with antiaging properties: A review of in vitro and in vivo studies

Kazeem,

Mellem,

Sabiu

2023

Food Frontiers

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Aging is a natural process by which organisms experience physiological decline leading to susceptibility to morbidity and mortality. There are no known antiaging drugs but there is a myriad of medicinal foods and plants that have been used in managing the state. Several studies have also been conducted on the antiaging properties of medicinal plants and foods, but these pieces of information are scattered. This paper attempts to integrate available information on medicinal foods and plants as well as isolated chemical compounds with antiaging potential. It also provides different models (in vitro and in vivo) that are used in evaluating the potency of natural products. Current literature on the subject was obtained from different databases such as PubMed, Google Scholar, and Web of Science. A total of 119 medicinal plants and 50 isolated compounds were reported in this study. Different models were also used to evaluate the efficacy of these plants which include in vitro (enzyme inhibition, use of cell lines) and in vivo (Caenorhabditis elegans, yeast, fruit fly, mice, and rats) models. It can be concluded that medicinal foods and plants are reservoirs of potential therapeutic agents that can efficiently modulate metabolic processes implicated in aging and its associated disorders.

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Ethanolic Fenugreek Extract: Its Molecular Mechanisms against Skin Aging and the Enhanced Functions by Nanoencapsulation

Cited by 8 publications

References 62 publications

Anti‐skin ageing activities of rice (Oryza sativa) bran soft and hard waxes in cultured skin cells

Anti‐skin ageing activities of rice (Oryza sativa) bran soft and hard waxes in cultured skin cells

Eight Indole Alkaloids from the Roots of Maerua siamensis and Their Nitric Oxide Inhibitory Effects

Medicinal foods and plants with antiaging properties: A review of in vitro and in vivo studies

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