Ethanolic leaf extract from <i>Strophanthus gratus</i> (Hook.) Franch. (Apocynaceae) exhibits anti-inflammatory and antioxidant activities

Baah, Samuel Ofori –; Borquaye, Lawrence Sheringham

doi:10.1080/23312025.2019.1710431

Cited by 12 publications

(14 citation statements)

References 36 publications

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“…In evaluating their anti-inflammatory effects, the carrageenan-induced paw oedema assay in day-old chicks (cockerels) was employed because of its sensitivity in testing new oral anti-inflammatory candidates (Roach and Sufka, 2003;Ofori-Baah and Borquaye, 2019). The intra-plantar injection of carrageenan causes the release of inflammatory markers.…”

Section: Discussionmentioning

confidence: 99%

“…The intra-plantar injection of carrageenan causes the release of inflammatory markers. This results in a biphasic phenomenon which involves different inflammatory mediators that work in sequence to produce the inflammatory response (Ofori-Baah and Borquaye, 2019). This biphasic phenomenon begins with the early phase (first phase) that ensues from the 0 th to 2 nd hour post-carrageenan injection.…”

Section: Discussionmentioning

confidence: 99%

“…One of the most common tests used in screening newer antiinflammatory agents is carrageenan-induced paw oedema. This method measures how much an agent (extract/drug) is able to reduce oedema caused by injecting carrageenan (an irritant agent) into the paw of an animal (chicks, mice or rats) (Roach and Sufka, 2003;Ofori-Baah and Borquaye, 2019). The anti-inflammatory effects of the extracts were evaluated using the above-mentioned model, as described by Boakye-Gyasi et al (2008).…”

Section: Carrageenan-induced Pedal Oedema Testmentioning

confidence: 99%

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In-vivo anti-inflammatory activity of different parts of Adansonia Digitata

Quartey¹,

Ayensu²,

Orman³

et al. 2021

J. Med. Plants Res.

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The aim of the study is to investigate the anti-inflammatory property of the different parts of Adansonia digitata (Malvaceae) extracts. A. digitata is an important medicinal plant to West Africa including Ghana. The plant is used effectively in folk medicine to treat inflammatory diseases such as joint disorders, asthma, toothache and painful swelling. Carrageenan-induced pedal oedema in 7-day old chicks was was the model used to determine the anti-inflammatory property of the extracts obtained from six different parts of A. digitata. The extracts were also assessed for their acute toxicity. The results from the acute toxicity test showed there were no behavioural changes, toxic signs, or death in the rats when given the highest dose (3000 mg/kg) of the extracts orally. The six extracts demonstrated varying degrees of anti-inflammatory effects, in a dose-dependent manner; with the stem extract giving the most potent activity with an ED 50 of 145.3 ± 7.6 mg/kg, followed by the flower (167.5 ± 10.42 mg/kg), leaves (169.7 ± 8.76 mg/kg), root bark (187.8 ± 11.2 mg/kg), fruit pulp (218.8 ± 6.86 mg/kg), and the seed (267.1 ± 12.3 mg/kg) as compared to the positive control (diclofenac, ED 50 = 55.08±6.11 mg/kg) (p < 0.0001).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Carrageenan-induced Pedal Oedema Testmentioning

confidence: 99%

See 1 more Smart Citation

In-vivo anti-inflammatory activity of different parts of Adansonia Digitata

Quartey¹,

Ayensu²,

Orman³

et al. 2021

J. Med. Plants Res.

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“…The carrageenan-induced edema model of inflammation in 7-day-old chicks was used to evaluate anti-inflammatory activity. The method used has been described in detail in our earlier publications (Borquaye et al, 2017, Ofori-Baah et al, 2019. Group sample size of five randomly selected chicks was used in this study.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Anti-inflammatory and antioxidant activities of extracts ofReissantia indica, Cissus cornifoliaandGrosseria vignei

et al. 2020

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Unpleasant side effects associated with prolonged use of current anti-inflammatory drugs have necessitated a need for new drugs with limited side effects. Plants rich in antioxidants have been suggested as potential sources of anti-inflammatory compounds. Thus, the antiinflammatory and antioxidant activities of extracts of Reissantia indica, Grosseria vignei and Cissus cornifolia-medicinal plants with widespread use in folkloric medicine in Ghana-were evaluated in this study. The phytochemical composition and total phenolic content (TPC) of these extracts were determined using standard methods. Antioxidant potential was screened using the ferric reducing antioxidant activity, nitric oxide and hydrogen peroxide scavenging, and the phosphomolybdenum assays. The anti-inflammatory activities were evaluated using an in vivo assay. Alkaloids, flavonoids, terpenoids, glycosides and coumarins were present in extracts of all three plants. The TPC of Reissantia indica (38.44 µg/g GAE) was twice that of Grosseria vignei (19.12 µg/g GAE) whereas Cissus cornifolia (7.59 µg/g GAE) had the lowest TPC. In all antioxidant tests, activities of the plant extracts varied in the order; Reissantia indica > Grosseria vignei > Cissus cornifolia, which was in agreement with the TPC data. All extracts exhibited potent anti-inflammatory activities, with the dose of extract required to cause half-maximal reduction in edema (ED 50 ) below 80 mg/ kg. Reissantia indica was the most potent anti-inflammatory extract with an ED 50 of 47.23 mg/kg. The ethanol extracts of Reissantia indica, Grosseria vignei, and Cissus cornifolia thus exhibited potent anti-inflammatory and antioxidant activities and may be important sources of novel antioxidant and anti-inflammatory agents.

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“…Bandawane et al investigated the anti-inflammatory and analgesic activities of the seed of Tamarindus indica and demonstrated a dosedependent activity of the leaf extracts on carrageenan-induced inflammation in rats (Bandawane et al, 2013). The methanol extract of the fruits of the plant has also been classified as possessing moderate anti-inflammatory activity (Mohammed et al, 2015) whereas the stem bark extracts were shown to possess substantial analgesic activity (Ukwuani & Hassan, 2014). Recently, Gupta and Singh showed that the aqueous and ethanolic extracts of the root of Tamarindus indica possess antiinflammatory activity, similar to the findings of this study.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Anti-inflammatory and anti-oxidant activities of ethanolic extracts of Tamarindus indica L. (Fabaceae)

et al. 2020

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Various parts of Tamarindus indica L are used to treat inflammatory disorders. This study evaluated the anti-inflammatory and antioxidant activities of the ethanolic extracts of the root and stem bark of the plant. The carrageenan-induced paw edema model of inflammation in chicks was used to assess anti-inflammatory activity. The phosphomolybdenum (PM) assay, 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical and hydrogen peroxide scavenging assays were used to investigate antioxidant potential. Total phenolic content was evaluated by the Folin-Ciocalteu method. Both stem bark and root extracts possessed similar total phenolic content (11-13 g/100 g AAE) and had comparable total antioxidant capacities (about 27 g/ 100 g GAE). However, the stem bark extract was a better scavenger of both DPPH radicals and hydrogen peroxide, with lower IC 50 values than the root extract. In the anti-inflammation test, both extracts exhibited dose-dependent reduction of edema, similar to the standard drugs used. The root extract, with ED 50 of 118.1 ± 1.9 mg/kg, proved superior to the stem bark extract, whose ED 50 was 154.5 ± 2.6 mg/kg. The results showed that both stem bark and root extracts possess potent antiinflammatory and anti-oxidant activity and confirm their use in folkloric medicine.

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Ethanolic leaf extract from Strophanthus gratus (Hook.) Franch. (Apocynaceae) exhibits anti-inflammatory and antioxidant activities

Cited by 12 publications

References 36 publications

In-vivo anti-inflammatory activity of different parts of Adansonia Digitata

In-vivo anti-inflammatory activity of different parts of Adansonia Digitata

Anti-inflammatory and antioxidant activities of extracts ofReissantia indica, Cissus cornifoliaandGrosseria vignei

Anti-inflammatory and anti-oxidant activities of ethanolic extracts of Tamarindus indica L. (Fabaceae)

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