Ethical Aspects of Tissue Engineering: A Review

Vries, Rob B. M. de; Oerlemans, Anke; Trommelmans, Leen; Dierickx, Kris; Gordijn, Bert

doi:10.1089/ten.teb.2008.0199

Cited by 66 publications

(57 citation statements)

References 146 publications

(207 reference statements)

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“…Although embryonic SCs present interesting properties, such as the ability to differentiate into hundreds of other cell types, the bioethical aspects involved in the study of these cells, especially for human embryos, have hindered advances in this field and research has thus been focused on adult SCs [1,[10][11][12] . Adult SCs can be obtained from adult specialized tissues, such as bone marrow [13][14][15][16] , skin [17,18] and fat [19][20][21][22][23] , where they likely act to renew cell populations and maintain tissue homeostasis, or help to repair the tissue in case of injury [18,24,25] .…”

Section: Introductionmentioning

confidence: 99%

Tooth-derived stem cells: Update and perspectives

Saito¹,

Silvério²,

Casati³

et al. 2015

WJSC

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Section: Introductionmentioning

confidence: 99%

Tooth-derived stem cells: Update and perspectives

Saito¹,

Silvério²,

Casati³

et al. 2015

WJSC

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“…Ethical issues regarding the use of cells for tissue engineering have been debated in both scientific and popular publications and mainly focus on the source of the cells used in TEMPs and the donation of cells 5,7 . Several of the ethical discussions have highlighted the controversies regarding the use of human embryonic stem cells.…”

Section: Clinical Researchmentioning

confidence: 99%

“…Another issue is sponsorship of clinical trials 6 . A recent study indicates that physicians overall have less confidence in industry-funded clinical trials and believe that government-sponsored clinical trials remain the best option to avoid any bias 7 .…”

Section: Clinical Researchmentioning

confidence: 99%

Tissue Engineered Constructs: Perspectives on Clinical Translation

Arbit²,

Herrick

et al. 2015

Ann Biomed Eng

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In this article, a “bedside to bench and back” approach for developing tissue engineered medical products (TEMPs) for clinical applications is reviewed. The driving force behind this approach is unmet clinical needs. Preclinical research, both in vitro and in vivo using small and large animal models, will help find solutions to key research questions. In clinical research, ethical issues regarding the use of cells and tissues, their sources, donor consent, as well as clinical trials are important considerations. Regulatory issues, at both institutional and government levels, must be addressed prior to the translation of TEMPs to clinical practice. TEMPs are regulated as drugs, biologics, devices, or combination products by the US Food and Drug Administration (FDA). Depending on the mode of regulation, applications for TEMP introduction must be filed with the FDA to demonstrate safety and effectiveness in premarket clinical studies, followed by 510(k) premarket clearance or premarket approval (for medical devices), biologics license application approval (for biologics), or New Drug Application approval (for drugs). A case study on nerve cuffs is presented to illustrate the regulatory process. Finally, perspectives on commercialization such as finding a company partner and funding issues, as well as physician culture change, are presented.

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“…The use of hESCs raises ethical concerns [49,50], but the debate is much quieter today than it was 10 years ago, mainly because the vast majority of researchers changed to hiPSCs which are widely available now and lack these concerns. Immunogenicity of the cell source is an important issue in clinical application.…”

Section: Advantages and Disadvantages Of The Different Pluripotent Cementioning

confidence: 99%

Engineering Cardiovascular Regeneration

et al. 2015

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The human heart has very limited regenerative capacity, making the loss of heart muscle tissue during myocardial infarction essentially irreversible. Regenerative medicine aims at promoting the formation of new functional heart muscle in an injured heart, either by stimulating myocyte proliferation, formation of myocytes from preexisting stem cells, direct reprogramming of fibroblasts into myocytes, or adding new muscle tissue from exogenous stem cell sources. Recent advances in stem cell research make these goals more realistic. This review provides a short overview about different approaches for cardiovascular regeneration, stem cell sources, and modes of application, focusing on current cardiac tissue engineering techniques and their way towards clinical application.

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Ethical Aspects of Tissue Engineering: A Review

Cited by 66 publications

References 146 publications

Tooth-derived stem cells: Update and perspectives

Tooth-derived stem cells: Update and perspectives

Tissue Engineered Constructs: Perspectives on Clinical Translation

Engineering Cardiovascular Regeneration

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