Precision Medicine encompasses decision making about prevention, diagnosis, and treatment of a particular disease in a patient tailored based on the information derived from a patient's genetic profile, environment, and lifestyle. It is patient-specific based on their specific clinical and biological characteristics with minimum side effects. With advancements in DNA sequencing technology, this concept gained attention among scientists. The projects like Human Genome Project and International HapMap Project provided deep insight into human genomics and information about specific disease-associated gene variants. Moreover, pharmacogenetics and pharmacogenomics have helped in understanding molecular basis of diseases and corresponding therapeutic strategy designed for individuals for a particular drug and the effect of multiple variations in genome on drug treatment, helping biomarker identification, influencing pathogen and drug effects on body, establishing the need for genomic biomarkers discovery for designing patient-specific treatment modalities for a specific disease.