The availability, affordability and usability of communication technologies have created new ways to conduct interpersonal qualitative research. Access to digital communications remains uneven, but the online environment provides an alternative, and at times a potentially preferable, research space. As Covid-19 has interrupted and disrupted the dominant assumption that qualitative research must be conducted in person, this paper outlines possibilities and reservations of online interpersonal methods. Though the standard ethical considerations of qualitative research hold true, we argue that these are necessary, but often inadequate, in the contexts of conducting online synchronous interpersonal research. Through centring relational and reflexive practice, we consider the associated pragmatic, methodological and ethical domains from feminist and virtual–material positional perspectives. Unpacking the complexities and possibilities of researching digital environments, we present six guiding principles to inform ethically responsive, methodologically robust and pragmatically feasible approaches to conducting online interpersonal qualitative research.