Abstract-In general, the applications of robots have shifted rapidly from industrial uses to social uses. This provides robots with the ability to naturally interact with human beings and socially fit into the human environment. The deployment of social robots in the healthcare system is becoming extensive as a result of the shortage of healthcare professionals, rising costs of healthcare and the exponential growth in the number of vulnerable populations such as the sick, the aged and children with developmental disabilities. Consequently, social robots are used in healthcare for providing health education and entertainment for patients in the hospital and for providing aids for the sick and aged. They are also used for dispensing drugs and providing rehabilitation as well as emotional and aging care. Hence, social robots improve the efficiency and quality of healthcare services. The interaction between social robots and human beings is known as human-robot interaction. Human-robot interaction in healthcare is faced with numerous challenges such as the fear of displacement of caregivers by robots, safety, usefulness, acceptability as well as appropriateness. These challenges ultimately lead to a low rate of acceptance of the robotic technology. Consequently, this paper extensively appraises humanrobot interaction in healthcare, their applications and challenges. Design, ethical and usability issues such as privacy, trust, safety, users' attitude, culture, robot morphology as well as emotions and deception arising from the interaction between humans and robots in healthcare are also reviewed in this paper.