Ethical priority of the most actionable system of biomolecules: the metabolome

Lewis, Cecil M.; McCall, Laura Isobel; Spicer, Paul

doi:10.1002/ajpa.23943

Cited by 12 publications

(4 citation statements)

References 27 publications

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“…Enquanto a metabolômica, em média, levanta menos preocupações éticas em relação à ancestralidade e é mais dinâmica do que a genômica, oferecendo oportunidades para intervenção, existem diferenças substanciais que exigem atenção, tais quais: a detecção de substâncias, como cocaína, em bancos de dados durante estudos populacionais, destaca a capacidade da metabolômica de rastrear o comportamento e a história de objetos, levantando questões sobre a privacidade e a interpretação precisa dessas descobertas (Lewis et al, 2019).…”

Section: éTica E Considerações Práticasunclassified

Exploring the Transformative Potential of Personalized Metabolomics in Osteogenesis Imperfecta

Carvalho,

Binda,

Destefani

et al. 2024

REASE

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O artigo científico aborda a importância da metabolômica como uma ferramenta essencial na pesquisa biomédica, destacando seu papel na ampliação do conhecimento molecular sobre doenças e no avanço da medicina personalizada. A metabolômica personalizada é reconhecida por seu potencial significativo em melhorar a assistência à saúde, identificando biomarcadores, alvos terapêuticos e compreendendo variações na resposta e metabolismo de medicamentos. O estudo ressalta a relevância da metabolômica na pesquisa biomédica, especialmente no contexto da Osteogênese Imperfeita (OI). Reconhecendo a capacidade da metabolômica personalizada de ampliar o conhecimento molecular sobre a OI, identificando metabólitos específicos, potenciais biomarcadores e alvos terapêuticos para essa condição genética rara, o estudo destaca, também, a necessidade de superar desafios, como a padronização de protocolos e a complexidade da análise de dados, enfatizando a importância da colaboração entre cientistas, profissionais médicos e pacientes para traduzir essas descobertas em práticas clínicas eficazes no manejo da OI.

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Section: éTica E Considerações Práticasunclassified

Exploring the Transformative Potential of Personalized Metabolomics in Osteogenesis Imperfecta

Carvalho,

Binda,

Destefani

et al. 2024

REASE

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“…To effectively address these ethical concerns, it is crucial to foster collaboration among researchers, ethicists, policy makers, and healthcare professionals. Together, they can develop guidelines, regulations, and best practices that promote the responsible and equitable advancement of metabolomics, microbial research, and personalized nutrition, maximizing their benefits for society while minimizing potential risks [37].…”

Section: Metabolomic Approaches To Decode Diet-microbiome Relationshipsmentioning

confidence: 99%

Bridging the Gap from Enterotypes to Personalized Dietary Recommendations: A Metabolomics Perspective on Microbiome Research

Bartsch,

Hahn,

Berkemeyer

2023

Metabolites

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Advances in high-throughput DNA sequencing have propelled research into the human microbiome and its link to metabolic health. We explore microbiome analysis methods, specifically emphasizing metabolomics, how dietary choices impact the production of microbial metabolites, providing an overview of studies examining the connection between enterotypes and diet, and thus, improvement of personalized dietary recommendations. Acetate, propionate, and butyrate constitute more than 95% of the collective pool of short-chain fatty acids. Conflicting data on acetate’s effects may result from its dynamic signaling, which can vary depending on physiological conditions and metabolic phenotypes. Human studies suggest that propionate has overall anti-obesity effects due to its well-documented chemistry, cellular signaling mechanisms, and various clinical benefits. Butyrate, similar to propionate, has the ability to reduce obesity by stimulating the release of appetite-suppressing hormones and promoting the synthesis of leptin. Tryptophan affects systemic hormone secretion, with indole stimulating the release of GLP-1, which impacts insulin secretion, appetite suppression, and gastric emptying. Bile acids, synthesized from cholesterol in the liver and subsequently modified by gut bacteria, play an essential role in the digestion and absorption of dietary fats and fat-soluble vitamins, but they also interact directly with intestinal microbiota and their metabolites. One study using statistical methods identified primarily two groupings of enterotypes Bacteroides and Ruminococcus. The Prevotella-dominated enterotype, P-type, in humans correlates with vegetarians, high-fiber and carbohydrate-rich diets, and traditional diets. Conversely, individuals who consume diets rich in animal fats and proteins, typical in Western-style diets, often exhibit the Bacteroides-dominated, B-type, enterotype. The P-type showcases efficient hydrolytic enzymes for plant fiber degradation but has limited lipid and protein fermentation capacity. Conversely, the B-type features specialized enzymes tailored for the degradation of animal-derived carbohydrates and proteins, showcasing an enhanced saccharolytic and proteolytic potential. Generally, models excel at predictions but often struggle to fully elucidate why certain substances yield varied responses. These studies provide valuable insights into the potential for personalized dietary recommendations based on enterotypes.

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“…Using the definition from the Human Metabolome Database, these endogenous metabolites (synthesized by the host) are supplemented by exogenous small molecules acquired from external sources, such as cosmetics, medication, dietary sources, and pollution ( 6 ). The human metabolome thus contains both endogenous and exogenous metabolites, representing the nexus of genetic and environmental influences ( 5 , 7 – 9 ).…”

Section: Introductionmentioning

confidence: 99%

Untargeted Fecal Metabolomic Analyses across an Industrialization Gradient Reveal Shared Metabolites and Impact of Industrialization on Fecal Microbiome-Metabolome Interactions

et al. 2022

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Ethical priority of the most actionable system of biomolecules: the metabolome

Cited by 12 publications

References 27 publications

Exploring the Transformative Potential of Personalized Metabolomics in Osteogenesis Imperfecta

Exploring the Transformative Potential of Personalized Metabolomics in Osteogenesis Imperfecta

Bridging the Gap from Enterotypes to Personalized Dietary Recommendations: A Metabolomics Perspective on Microbiome Research

Untargeted Fecal Metabolomic Analyses across an Industrialization Gradient Reveal Shared Metabolites and Impact of Industrialization on Fecal Microbiome-Metabolome Interactions

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