Diseases in the maxillofacial sphere and especially the dysfunctional syndrome of the stomatognathic system have many connections and interferences with the psychiatric pathology and why not last, but not least the appearance and aesthetics that have an impact on social life and success. On the other hand, there has been a significant increase in the use of antipsychotics in recent decades. The negative impact on oral health has also increased. The ability to diagnose mental illness is essential due to the social stigma associated with these disorders and a correct differential diagnose as well. This article describes the oro-dental rehabilitation of one case, psychiatrically treated, with mandibular and maxilla missing teeth and dental destruction and prosthetic damage, temporomandibular disorders pathology due to the disbalanced occlusion and depression and anxiety, with specific medication, fixed and removable hybrid prosthesis and intra oral complex rehabilitation.