Ethnic and Geographical Distributions of CYP2C19 Alleles in the Populations of Southeast Asia

Yusuf, Irawan; Djojosubroto, Meta W.; Ikawati, Risma; Lum, Koji; Kaneko, Akira; Marzuki, Sangkot

doi:10.1007/978-1-4615-0059-9_3

Cited by 13 publications

(12 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The combination of a high * 2 and * 3 allele frequency in the Iruna population of PNG, however, results in a high incidence of genotypic PMs (48.9 per cent). This PM incidence is intermediate between that reported for Indonesia (34 per cent [22]) and for Vanuatu (61.0-70.5 per cent [7,20]) but higher than that reported previously for PNG (36 per cent [12]). 10.6 per cent of the Iruna population were homozygous * 3 /* 3 , whereas these individuals are absent or have a low incidence in East Sepik (0-2 per cent [12]) and Vanuatu (1.2 per cent;[7] Figure 2).…”

Section: Discussioncontrasting

confidence: 75%

“…The * 3 allele is absent in Caucasian populations [5] but is found in Asian populations at a frequency of 0.045-0.156 [21]. To our knowledge, the highest incidence of the CYP219 *3 allele reported is in Indonesian populations of south-east Asia (0.37);[22] thus, the frequency of the * 3 allelic variant in the Iruna population of PNG is one of the highest reported to date.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A high incidence of polymorphic CYP2C19 variants in archival blood samples from Papua New Guinea

et al. 2008

View full text Add to dashboard Cite

There is considerable inter-ethnic variability in the incidence of CYP2C19 genetic poor metabolisers (var/var). About 3 per cent of Caucasians are CYP2C19 var/var. By contrast, an extremely high incidence (70 per cent) is observed in the Melanesian island of Vanuatu. The colonisation of the Pacific Islands is believed to have involved migration through Papua New Guinea (PNG), and hence a high incidence may also be expected in this population. The reported incidence in PNG was only 36 per cent, however. PNG is a country of extensive ethnic diversity, and the incidence of the CYP2C19 var/var in other regional populations of PNG is currently not established. In this study, restriction fragment length polymorphism-polymerase chain reaction analysis of archival blood serum samples was used to determine the prevalence of the CYP2C19*2 and *3 variant alleles in three different ethnic and geographically isolated populations of PNG. In the largest population studied (Iruna), the frequency of both variant CYP2C19 alleles was high (0.37 and 0.34, respectively). Specifically, the frequency of the CYP2C19*3 allele was significantly higher than in the PNG (East Sepik) population reported previously (0.34 vs 0.16; p <0.0001). In the Iruna population, 48.9 per cent of the samples were homozygous variants for CYP2C19*2 or *3, which although higher was not statistically different from the East Sepik population (36 per cent). The results of this study indicated that other regional populations of PNG also have a relatively high incidence of the CYP2C19 genetic polymorphism compared with Caucasian populations. The high incidence reported in Vanuatu, however, may be due to genetic drift rather than a PNG founder population, as the Vanuatu population is dominated by the CYP2C19*2 allele, with a lower contribution from the *3 allelic variant.

show abstract

Section: Discussioncontrasting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

A high incidence of polymorphic CYP2C19 variants in archival blood samples from Papua New Guinea

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Those ethnic groups were selected in order to obtain a subject population that represented the native Indonesian population. According to anthropologic and genetic review of the experts in some literatures, [27][28][29][30][31][32] the selected ethnic groups are included in one "family", which has similar genetic characteristics. Such similarities in geographic, culture and phenotype were assumed to be a valid representative of a population that will bring advantages for other studies in the future.…”

Section: Discussionmentioning

confidence: 99%

“…27 Furthermore, signet ring cell carcinoma and mucinous adenocarcinoma were significantly dominant in the young patients compared to the old patients.…”

Section: Tumor Location Histopathology and Gradingmentioning

confidence: 96%

Colorectal cancer among young native Indonesians: A clinicopathological and molecular assessment on microsatellite instability

Sudoyo¹,

Hernowo

Krisnuhoni³

et al. 2010

Med J Indones

View full text Add to dashboard Cite

Aim: To obtain clinicopathological characteristics of colorectal cancer among young native Indonesians and to assess MLH1, MSH2, and SMAD4 protein expressions, comparing them with a matched population of colorectal cancer patients aged 60 years old and older.Methods: Medical records of colorectal cancer patients aged 40 years or younger and 60 years or older from several hospitals in three Indonesian cities -Jakarta, Makassar, and Bandung -were reviewed. The "native" ethnic groups were selected from those originating from Java, Makassar (South Celebes), Miinangkabau (West Sumatra). Ethnicity of 121 colorectal carcinoma patients was confirmed by fulfilling requirements in a questionnaire. Tumor specimens of those patients underwent evaluation for histopathology, tumor grading as well as immunohistochemical analysis to assess MLH1, MSH2 protein expressions to detect microsatellite instability mutation pathway and SMAD4 protein expression to reconfirm that the specimens were not microsatellite instability origin.Results: There were 121 colorectal carcinoma cases of Sundanese, Javanese, Macassarese and Minangkabau ethnic group. This study indicated that colorectal cancer has statistically different grade (p = 0.001) between the young and the older patients. Immunohistochemical staining for MSH2 protein and MLH1 were done for 92 and 97 specimens respectively. There was no significant difference between the expressions of MLH1 and MSH2 on tumor grading, indicated there was no correlation between microsatellite instability and tumor grading in this study. Conclusion:Colorectal cancer in young native Indonesian patients (40 years old or less) was not different in clinicopathological characteristics compared to older patients (60 years old or more) in similar ethnic groups. There was also no difference in MSH2 and MLH1 protein expressions, important indicators of microsatellite instability and .

show abstract

“…Previous study has indicated that the cytochrome P450 (CYP) 2C19 poor metabolizers may exhibit less antiplatelet activity when they were exposed to the same clopidogrel regimen than other healthy volunteers. The variation of prevalence of CYP2C19 poor metabolizers in different populations (3-6% of Europeans and Africans, and 13-23% of Asians) thus need to be taken into account when interpreting our findings [19]. Fourthly, we did not report risk of bleeding according to the duration of clopidogrel as it was not the main focus of our study.…”

Section: Discussionmentioning

confidence: 99%

Duration of dual antiplatelet therapy following percutaneous coronary intervention on re-hospitalization for acute coronary syndrome

Chen

Hsiao

Lee

et al. 2014

BMC Cardiovasc Disord

View full text Add to dashboard Cite

BackgroundThe optimal duration of dual antiplatelet therapy after percutaneous coronary intervention (PCI) remains uncertain. The objective of this study was to examine the association between duration of dual antiplatelet therapy and re-hospitalization for acute coronary syndrome (ACS) in ACS patients who underwent PCI.MethodsWe identified 975 newly diagnosed ACS patients who underwent PCI between July, 2007 and June, 2009, at a medical center in Taiwan. Cox proportional hazard models were used to examine the association between duration of dual antiplatelet therapy (9 months, 12 months and 15 months) and risks of re-hospitalization for ACS.ResultsAt a mean follow-up of 2.3 years, we found that use of clopidogrel for ≥ 12 months was associated with a decreased risk of re-hospitalization for ACS (adjusted HR 0.59, 95% CI 0.36-0.95; p = 0.03). However, use of clopidogrel for ≥ 15 months was not associated with a decreased risk of re-hospitalization for ACS (adjusted HR 0.57, 95% CI 0.29-1.13; p = 0.11). Similar results were found in patients who implanted drug-eluting stents (DES), for whom at least 12 months of clopidogrel therapy is especially critical.ConclusionThe benefit of ≥ 12 months of clopidogrel use in reducing the risk of re-hospitalization for ACS was significant among ACS patients who underwent PCI and was especially critical for those who implanted DES.

show abstract

Ethnic and Geographical Distributions of CYP2C19 Alleles in the Populations of Southeast Asia

Cited by 13 publications

References 32 publications

A high incidence of polymorphic CYP2C19 variants in archival blood samples from Papua New Guinea

A high incidence of polymorphic CYP2C19 variants in archival blood samples from Papua New Guinea

Colorectal cancer among young native Indonesians: A clinicopathological and molecular assessment on microsatellite instability

Duration of dual antiplatelet therapy following percutaneous coronary intervention on re-hospitalization for acute coronary syndrome

Contact Info

Product

Resources

About