PurposeHigh levels of youth unemployment in Africa, the difficulty of accessing salaried jobs, and the weakness of public institutions in charge of employment issues push youths towards informal channels that can help them find jobs. Among these informal channels, religion has been playing an increasingly important role. Thus, this study aimed to analyse the effects of religion on youths' access to self-employment.Design/methodology/approachThis study used data from the survey on the improvement of youth employment policies in Francophone Africa—conducted in 2018 by the Laboratory for Economic and Social Research and Studies (LARES) of Marien Ngouabi University—to estimate the effects of religion on access to self-employment. The econometric model employed is a two-stage model. Conditional mixed process developed by Roodman (2011) was used to verify the model's robustness.FindingsThe results indicate that religion exhibits a positive and significant effect on access to self-employment. This effect is stronger for youths from Muslim communities than for those from other religious communities, compared to youths who do not engage in religious communities.Social implicationsBased on the current dynamics observed in numerous African countries with respect to employment access, these results imply that religious denominations should be considered when developing policies and programs related to employment, particularly for youths.Originality/valueThe approach followed in this study contributes to the literature predominantly by demonstrating how the network theory approach helps explain, to some extent, the link between religion and access to employment in general and access to self-employment, particularly in developing economies—mainly in sub-Saharan Africa, where the recourse to informal channels of access to self-employment constitutes a significant solution approach for youths.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-02-2023-0097