Ethnic differences in alpha-1 antitrypsin deficiency in the United States of America

Serres, Frederick J. de; Blanco, Ignacio; Fernández-Bustillo, Enrique

doi:10.1177/1753465810365158

Cited by 43 publications

(27 citation statements)

References 26 publications

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“…Most were White (97%), which reflects the biology of Alpha-1 (de Serres, Blanco, & Fernandez-Bustillo, 2010). The registry members were mostly female (81.2%).…”

Section: Methodsmentioning

confidence: 99%

Living with a rare health condition: the influence of a support community and public stigma on communication, stress, and available support

Zhu

Smith

Parrott

2017

Journal of Applied Communication Research

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People affected by rare diseases often have limited coping resources and sometimes face stigma. They build communities with others who share their conditions, but not all members may benefit from these communities. This study investigated how adults with a rare genetic health condition (Alpha-1 antitrypsin deficiency; AATD) think about both the Alpha-1 community and public stigma about AATD, and how these cognitions were associated with their communication responses and well-being. The results showed that people with AATD encountered stigmatization from various sources, including family, employers, healthcare providers, and insurance companies. Stronger public stigma predicted more secrecy, more stress, and less available support. Stronger group identification with the Alpha-1 community predicted less secrecy; stronger group activism predicted more available support and more communication to challenge stigmatizers. Post-hoc analyses showed significant interactions between public stigma and group cognitions on communication to challenge stigmatizers. Practical implications for bolstering communities to improve the well-being of people with rare diseases were discussed.

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“…Most were White (97%), which reflects the biology of Alpha-1 (de Serres, Blanco, & Fernandez-Bustillo, 2010). The registry members were mostly female (81.2%).…”

Section: Methodsmentioning

confidence: 99%

Living with a rare health condition: the influence of a support community and public stigma on communication, stress, and available support

Zhu

Smith

Parrott

2017

Journal of Applied Communication Research

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“…While the ZZ genotype is relatively well-studied, there is little information regarding MZ, SZ, and other less common genotypes and to date there have been no investigations into the functional consequences of AATD heterozygosity. This is a vital clinical and public health question, as there are predicted to be over 6.6 million MZ and 230,000 SZ individuals in the US alone (de Serres, Blanco, and Fernandez-Bustillo 2010) and the total economic costs of COPD in the US were estimated to be almost $50 billion in 2010 (National Heart 2009). From a basic research perspective, a careful examination of AATD heterozygosity may lead to a new appreciation of this understudied area and the development of new therapies.…”

Section: Resultsmentioning

confidence: 99%

Alpha-1 Antitrypsin Deficiency – A Genetic Risk Factor for COPD

Carroll¹,

O’Connor²,

Reeves³

et al. 2012

Chronic Obstructive Pulmonary Disease - Current Concepts and Practice

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“…While we hypothesized that the biological factors that increase black smokers' vulnerability to COPD would also elevate risks in never-smokers (e.g., shorter sitting height [18] and/or poorer metabolism of cigarette smoke [19]), it is likely that different factors are in play. An example may be alpha-1 antitrypsin deficiency, a genetic mutation linked to higher risk of COPD, which is more prevalent among white Americans than blacks [28]. However, if alpha-1 antitrypsin deficiency plays a role, it is unclear why the influence would not be comparable for black-white differences in women as well.…”

Section: Discussionmentioning

confidence: 99%

COPD in a Population-Based Sample of Never-Smokers: Interactions among Sex, Gender, and Race

Fuller‐Thomson

Chisholm

Brennenstuhl

2016

International Journal of Chronic Diseases

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This observational epidemiological study investigates sex/gender and racial differences in prevalence of COPD among never-smokers. Data were derived from the 2012 Center for Disease Control's Behavioral Risk Factor Surveillance System. The sample consisted of 129,535 non-Hispanic whites and blacks 50 years of age and older who had never smoked. Descriptive and multivariable analyses were conducted, with the latter using a series of logistic regression models predicting COPD status by sex/gender and race, adjusting for age, height, socioeconomic position (SEP), number of household members, marital status, and health insurance coverage. Black women have the highest prevalence of COPD (7.0%), followed by white women (5.2%), white men (2.9%), and black men (2.4%). Women have significantly higher odds of COPD than men. When adjusting for SEP, black and white women have comparably higher odds of COPD than white men (black women OR = 1.66; 99% CI = 1.46, 1.88; white women OR = 1.49; 99% CI = 1.37, 1.63), while black men have significantly lower odds (OR = 0.62; 99% CI = 0.49, 0.79). This research provides evidence that racial inequalities in COPD (or lack thereof) may be related to SEP.

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Ethnic differences in alpha-1 antitrypsin deficiency in the United States of America

Cited by 43 publications

References 26 publications

Living with a rare health condition: the influence of a support community and public stigma on communication, stress, and available support

Living with a rare health condition: the influence of a support community and public stigma on communication, stress, and available support

Alpha-1 Antitrypsin Deficiency – A Genetic Risk Factor for COPD

COPD in a Population-Based Sample of Never-Smokers: Interactions among Sex, Gender, and Race

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