2021
DOI: 10.1371/journal.pmed.1003672
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Ethnic differences in guideline-indicated statin initiation for people with type 2 diabetes in UK primary care, 2006–2019: A cohort study

Abstract: Background Type 2 diabetes is 2–3 times more prevalent in people of South Asian and African/African Caribbean ethnicity than people of European ethnicity living in the UK. The former 2 groups also experience excess atherosclerotic cardiovascular disease (ASCVD) complications of diabetes. We aimed to study ethnic differences in statin initiation, a cornerstone of ASCVD primary prevention, for people with type 2 diabetes. Methods and findings Observational cohort study of UK primary care records, from 1 Januar… Show more

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Cited by 25 publications
(11 citation statements)
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“…Ethnicity was grouped into 16 categories in primary care and 11 categories in secondary care, which we further re‐grouped as the following: (1) White, (2) South Asian, (3) Black, and (4) Mixed/other (Table S1 ). We considered this re‐grouping necessary to ensure sufficient sample sizes within each ethnic group, and to follow precedent studies using the same data sources, 12 , 33 , 34 as well as the ethnic groupings used in the 2011 England and Wales census. 35 If the two sources for ethnicity provided different categorizations, then we used ethnicity as defined in the CPRD since these data have been shown to be more reliable than HES inpatient data.…”
Section: Methodsmentioning
confidence: 99%
“…Ethnicity was grouped into 16 categories in primary care and 11 categories in secondary care, which we further re‐grouped as the following: (1) White, (2) South Asian, (3) Black, and (4) Mixed/other (Table S1 ). We considered this re‐grouping necessary to ensure sufficient sample sizes within each ethnic group, and to follow precedent studies using the same data sources, 12 , 33 , 34 as well as the ethnic groupings used in the 2011 England and Wales census. 35 If the two sources for ethnicity provided different categorizations, then we used ethnicity as defined in the CPRD since these data have been shown to be more reliable than HES inpatient data.…”
Section: Methodsmentioning
confidence: 99%
“…This is consistent with previous studies using English primary care data. 17 As this is a descriptive study, multiple imputation techniques were not employed as we were not trying to gain an unbiased estimate of a single exposure-outcome association, and therefore did not have an analytic model around which to build an imputation procedure. Additionally, the missing at random assumption (required for imputation) was unlikely to hold, e.g.…”
Section: Statistical Modelsmentioning
confidence: 99%
“…Several clinical factors, such as diabetes and obesity had been identified as predictors for LLM use [12]. Inversely, several sociodemographic characteristics, such as ethnicity and the availability of health insurance had been found to be negatively associated with the use of LLM [13,14]. In Malaysia, the prevalence of LLM use among individuals with hypercholesterolemia was previously reported [15], however its use among high CVD risk population has yet to be explored.…”
Section: Introductionmentioning
confidence: 99%