Ethnic differences in stratum corneum functions between Chinese and Thai infants residing in Bangkok, Thailand

Fujimura, Tsutomu; Miyauchi, Yuhei; Shima, Kyoko; Hotta, Mitsuyuki; Tsujimura, Hiroji; Kitahara, Takashi; Palungwachira, Pakhawadee; Laohathai, Diane; Chanthothai, Jetchawa; Nararatwanchai, Thamthiwat

doi:10.1111/pde.13335

Cited by 9 publications

(5 citation statements)

References 16 publications

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“…18 Likewise, TEWL on the upper arm (not on the thigh and buttock) were inversely correlated with age in Thai children, not in Chinese, aged 6-24-month old. 19 In contrast, we showed here that TEWL on the shin were positively correlated with age in girls aged >12 months to 3-year old, and boys aged 1 month to 12-month old, in consistent with other study in Chinese…”

Section: Discussionsupporting

confidence: 93%

“…The trend of changes in stratum corneum hydration levels was similar to that in TEWL. Previous study demonstrated that stratum corneum hydration levels on the upper arm were lower in 13–24‐month‐old infants than in 2–12‐month‐old infants 19 . Correspondingly, we show here that stratum corneum hydration levels were higher in infants 1–12‐month old than in that over 12‐month old.…”

Section: Discussionsupporting

confidence: 84%

“…Previous study demonstrated that stratum corneum hydration levels on the upper arm were lower in 13-24month-old infants than in 2-12-month-old infants. 19 Correspondingly, we show here that stratum corneum hydration levels were higher in infants 1-12-month old than in that over 12-month old. Interestingly, stratum corneum hydration levels tended to increase in the first year of life in both boys and girls, which is in agreement with prior study and is ascribed to the maturation of eccrine gland function.…”

Section: Discussionsupporting

confidence: 75%

“…Previous studies showed that both TEWL and stratum corneum hydration levels on the upper inner arm and the dorsal forearm were negatively correlated with age in a cohort of aged 3 months to 50‐year old 18 . Likewise, TEWL on the upper arm (not on the thigh and buttock) were inversely correlated with age in Thai children, not in Chinese, aged 6–24‐month old 19 . In contrast, we showed here that TEWL on the shin were positively correlated with age in girls aged >12 months to 3‐year old, and boys aged 1 month to 12‐month old, in consistent with other study in Chinese showing that TEWL on the upper arm were higher in 13–24‐month‐old infants than in 2–12‐month‐old infants 20 .…”

Section: Discussionmentioning

confidence: 91%

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Trend of changes in epidermal biophysical properties in the Chinese aged 1 month to 17‐year old

Lai²,

Wang

et al. 2023

Skin Research and Technology

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Background: Although it is known that epidermal biophysical properties vary with age and gender, the changes in epidermal biophysical properties over the time from baby to adolescence have not been elucidated yet. In the present study, we assessed the trend of changes in transepidermal water loss rates (TEWL), stratum corneum hydration, and skin surface pH in Chinese children. Participants and methods:A total of 780 boys and 610 girls, aged 1 month to 17-year old, were enrolled in this study. TEWL and stratum corneum hydration on the forearm and the shin were measured with GPSkin Barrier, whereas skin surface pH was measured with portable skin pH meter.Results: Overall, TEWL and stratum corneum hydration levels decreased, whereas skin surface pH increased in children from 1-month old to 17-year old. Significant decline in TEWL was observed on both the forearm and the shin of girls, and the shin of boys aged 13-17-year old. Similarly, marked decline in stratum corneum hydration levels started at ages of 6-12-year old. In contrast, decline in skin surface pH was observed in both girls and boys aged one to 12-month old except on the forearm of boys. Afterward, skin surface pH remained either stable or slight increase except on the shin of boys aged >12 months to 3-year old.Conclusions: These results demonstrate that both TEWL and stratum corneum hydration levels decrease, whereas skin surface pH increases in children aged 1 month to 17-year old. The changes in these biophysical properties vary with age, gender, and body site.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 84%

Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 91%

See 2 more Smart Citations

Trend of changes in epidermal biophysical properties in the Chinese aged 1 month to 17‐year old

Lai²,

Wang

et al. 2023

Skin Research and Technology

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“…A lower NMF and ceramide content was observed in young children compared to adult epidermis [7, 27, 28]. In addition, ethnic variations in SC ceramide levels have been described [29].…”

Section: Biochemical Composition Adaptationmentioning

confidence: 99%

How do the skin barrier and microbiome adapt to the extra‐uterine environment after birth? Implications for the clinical practice

Darlenski

Fluhr

2023

Intern J of Cosmetic Sci

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The multiple protective functions of the skin derive from the interactions between epithelial skin and immune cells as well as the commensal microbiota. Developed in the last trimester of intra‐uterine life, the skin barrier adapts dynamically after birth. Specific differences in the structure and physiology have been disclosed between infant and adult skin. The stratum corneum of infants is thinner and structured by thicker corneocytes with a more anisotropic surface in comparison to adult skin. Lower levels of the natural moisturizing factor and its constituents, together with the increased protease activity in the epidermis result in dry baby skin and ongoing adaptation of the desquamation to the extra‐uterine environment. Infant epidermis is characterized by an accelerated proliferation rate and clinically competent permeability barrier in term neonates, despite the higher baseline values of transepidermal water loss in infants. The skin surface of newborns is less acidic, which could increase susceptibility to diaper and atopic dermatitis. Immediately after birth, skin is colonized by commensal bacteria—a process dependent on the mode of delivery and of major importance for the maturation of the immune system. Skin bacterial diversity and dysbiosis have been related to different pathology such as atopic and seborrheic dermatitis. This paper focuses on the ongoing structural, functional and biochemical adaptation of the human skin barrier after birth. We discuss the interactions on the ‘skin barrier/ microbiota/ immune system’ axis and their role in the development of competent functional integrity of the epidermal barrier.

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Experimental Variability in TEWL Data

Peer

Burli²,

Maibach³

2022

Dermal Absorption and Decontamination

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Ethnic differences in stratum corneum functions between Chinese and Thai infants residing in Bangkok, Thailand

Abstract: Background/Objectives: Ethnic and racial differences in infant skin have not been

Cited by 9 publications

References 16 publications

Trend of changes in epidermal biophysical properties in the Chinese aged 1 month to 17‐year old

Trend of changes in epidermal biophysical properties in the Chinese aged 1 month to 17‐year old

How do the skin barrier and microbiome adapt to the extra‐uterine environment after birth? Implications for the clinical practice

Experimental Variability in TEWL Data

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