Ethnic differences in the outcome of serum screening for Down's syndrome

Gilbert, Lucy; Nicholl, Jon; Alex, Susie; Smethurst, Ian; Mander, Anthony M; Andrews, A. H.; Patrick, Janet

doi:10.1136/bmj.312.7023.94

Cited by 16 publications

(14 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gilbert et al, 1996), with more false-positives in ethnic minorities, which lead to unnecessary anxiety and invasive investigations.…”

Section: Learning Disability In Ethnic Minority Communitiesmentioning

confidence: 99%

Learning disabilities and ethnicity: achieving cultural competence

O'Hara¹

2003

Adv. psychiatr. treat

View full text Add to dashboard Cite

Despite the higher prevalence of learning disabilities among some minority ethnic communities and the greater burden of care, families from minority ethnic communities with a member who has learning disabilities are doubly disadvantaged as a result of racial discrimination and culturally inappropriate forms of care and service provision. This paper looks at the issue of discrimination, as well as the generally negative attitudes towards people with learning disabilities, and synthesises these into the concept of ‘double jeopardy’. It concludes by proposing ways of developing cultural competence in the delivery of care to this population.

show abstract

“…Gilbert et al, 1996), with more false-positives in ethnic minorities, which lead to unnecessary anxiety and invasive investigations.…”

Section: Learning Disability In Ethnic Minority Communitiesmentioning

confidence: 99%

Learning disabilities and ethnicity: achieving cultural competence

O'Hara¹

2003

Adv. psychiatr. treat

View full text Add to dashboard Cite

show abstract

“…This may be an unduly optimistic figure in populations with a high proportion of South Asians. Gilbert et al 5 reported a 27% uptake of amniocentesis in Indian Asians and Wald et al 2 reported a 42% uptake in the Bangladeshi ethnic group. Such figures would adversely affect prevention of Down's syndrome births and prejudice the public health benefits of screening.…”

Section: Introductionmentioning

confidence: 99%

The value of screening for Down's syndrome in a socioeconomically deprived area with a high ethnic population

Ford¹,

Moore²,

Jordan³

et al. 1998

BJOG

View full text Add to dashboard Cite

Objective To assess the utility of biochemical antenatal screening for Down's syndrome in a socioeconomically deprived area with a high proportion of Asian women from the Indian Subcontinent. Design Audit of Down's syndrome biochemical screening service over a four-year period.Setting Teaching hospital and community antenatal clinic in inner city Birmingham.Population Women booked between October 1992 and December 1996. Methods Blood for screening was collected between 14 and 21 weeks gestation, alpha-fetoprotein and intact human chorionic gonadotrophin were measured in serum and the risk of Down's syndrome was calculated.Main outcome measures Uptakes of screening and amniocentesis, screen positive rate, odds of being affected given a positive result, miscarriages associated with amniocentesis offered following a high risk result, detection rate, number of Down's cases prevented and a cost analysis. Outcome measures were compared between Asians and Caucasians.Results Overall 1 1,974 women (71y0) accepted serum screening. The screen positive rate was 8.3% in Asians and 5.0% in Caucasians. The uptake of amniocentesis in women following a high risk result was 54% overall (35% Asian, 67% Caucasian). Nineteen cases of Down's syndrome were identified, of which 13 occurred in women who opted for biochemical screening. The detection rate of the biochemical screening programme was 85% (1 1/13). Of these 11 cases, six (none of whom were Asian) elected to have an amniocentesis, of whom four thereafter had a termination. ConclusionIn this study the public health benefits of screening for Down's syndrome in a socioeconomically deprived area with a high Asian population, were small.

show abstract

“…EDITOR,—Lucy Gilbert and colleagues report a 3.5-fold increase in the proportion of women found to be positive on screening for Down's syndrome when rates among Indian Asian women were compared with those among white women 1. This prompted me to examine the data from Oldchurch Hospital's screening programme.…”

mentioning

confidence: 99%

Median values and maternal weight specific to the ethnic group should be used

Spencer

1996

BMJ

View full text Add to dashboard Cite

Ethnic differences in the outcome of serum screening for Down's syndrome

Cited by 16 publications

References 5 publications

Learning disabilities and ethnicity: achieving cultural competence

Learning disabilities and ethnicity: achieving cultural competence

The value of screening for Down's syndrome in a socioeconomically deprived area with a high ethnic population

Median values and maternal weight specific to the ethnic group should be used

Contact Info

Product

Resources

About