Ethnic Differences in the Prevalence and Predictors of Restless Legs Syndrome between Hispanics of Mexican Descent and Non-Hispanic Whites in San Diego County: A Population-Based Study

Sawanyawisuth, Kittisak; Palinkas, Lawrence A.; Ancoli‐Israel, Sonia; Dimsdale, Joel E.; Loredo, José S.

doi:10.5664/jcsm.2338

Cited by 22 publications

(10 citation statements)

References 54 publications

(97 reference statements)

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“…73 In this large study, there were 1754 Hispanics of Mexican descent and 1913 non-Hispanic whites. Using telephone interview and asking 4 questions consistent with 2003 IRLSSG criteria, RLS/WED prevalence was 14.4% in Hispanics of Mexican descent and 18.3% in non-Hispanic whites.…”

Section: The Americasmentioning

confidence: 98%

“…65 To date, there have been 10 epidemiologic studies that have estimated RLS/WED prevalence in the United States, broadly or in regions/ states. 4,[66][67][68][69][70][71][72][73][74] Unlike most other regions of the world, the United States is largely an immigrant population, and when conducting epidemiologic studies, this allows for interesting inferences regarding the potential role of genetics, ethnicity, environment, and culture on the expression of disease. RLS/WED prevalence ranged among studies from 0.4% to 18.3%.…”

Section: The Americasmentioning

confidence: 99%

See 1 more Smart Citation

Restless Leg Syndrome Across the Globe

Koo

2015

Sleep Medicine Clinics

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Section: The Americasmentioning

confidence: 98%

Section: The Americasmentioning

confidence: 99%

Restless Leg Syndrome Across the Globe

Koo

2015

Sleep Medicine Clinics

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“…16 17 Race/ethnicity, sex, and age Few studies have examined the prevalence RLS/WED by race/ethnicity within the same population, and noncomparison reports have suggested that the proportion of people with RLS/WED, especially those experiencing symptoms at least once a month, is higher among white people than in other populations. [12][13][14][15][16][17][18][19][20][21][22] In adults over the age of 35, RLS/WED occurs about twice as often in women as in men. 3 23 However, virtually no sex difference is seen for adults under 35 years old.…”

Section: Clinical Definition Of Rls-wedmentioning

confidence: 99%

New concepts in the management of restless legs syndrome

Garcı́a-Borreguero¹,

Cano-Pumarega²

2017

BMJ

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Restless legs syndrome (RLS), also known as Willis-Ekbom disease (WED) is a neurological condition with an overall prevalence in adults of 5-10% in Europe and North America. It is characterised by strong feelings of restlessness and distressing paraesthesia-like sensations in the lower legs, particularly when at rest. The symptoms vary considerably in severity and frequency. RLS/WED has a variable clinical expression influenced by genetic, environmental, and medical factors. Research into the pathophysiology of RLS/WED has found that various genetic markers and existing dysfunctions in dopaminergic mechanisms and iron mechanisms play a central role. Until recently, the first line treatment of RLS/WED was with low dose dopamine agonists, with three drugs having been approved by the US Food and Drug Administration and the European Medicines Agency. However, the occurrence of dopaminergic augmentation and an overall increase in severity of symptoms during long term treatment with dopamine agonists is leading to a shift towards non-dopaminergic alternatives as initial treatments, and particularly to αδ ligands. Recent international guidelines recommend, whenever possible, to start treatment with these drugs (αδ ligands) to avoid augmentation from the start. Other (eg, glutamatergic or adenosine) neurotransmitters might also play an important role in causing RLS/WED and might thus lead to new treatments.

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“…A more recent regional study using data from a telephone questionnaire found that 14.4% of Mexican Americans self-reported restless legs symptoms. 7 Despite recent attention given to disturbed sleep in Mexican Americans, the literature is still lacking in breadth. This is unfortunate, as many of the risk factors for sleep disorders such as obesity, diabetes, alcohol use, and smoking are highly prevalent in Mexican American populations.…”

mentioning

confidence: 99%

The Link between Sleep Disturbance and Depression among Mexican Americans: A Project FRONTIER Study

Roane

Johnson

Edwards

et al. 2014

Journal of Clinical Sleep Medicine

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In this study, Mexican Americans reported higher rates of sleep disturbances than non-Hispanic whites. Disturbed sleep was positively associated with depression and the factor scores for Dysphoria and Cognitive Impairment in both groups. Given the paucity of research on sleep disorders in Mexican Americans, identifying what sleep disorders are present and the impact treating these sleep disorders have on depression warrant further investigation.

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Ethnic Differences in the Prevalence and Predictors of Restless Legs Syndrome between Hispanics of Mexican Descent and Non-Hispanic Whites in San Diego County: A Population-Based Study

Cited by 22 publications

References 54 publications

Restless Leg Syndrome Across the Globe

Restless Leg Syndrome Across the Globe

New concepts in the management of restless legs syndrome

The Link between Sleep Disturbance and Depression among Mexican Americans: A Project FRONTIER Study

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