Ethnic differences in total and HDL cholesterol among Turkish, Moroccan and Dutch ethnic groups living in Amsterdam, the Netherlands

Ujcic-Voortman, Joanne K.; Bos, G.A.M. van den; Baan, Caroline A.; Uitenbroek, Daan G.; Verhoeff, Arnoud P.; Seidell, Jacob C.

doi:10.1186/1471-2458-10-740

Cited by 20 publications

(19 citation statements)

References 23 publications

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“…Evidence was presented indicating that genetic variations in the CETP gene locus may bring about significant differences at HDL-cholesterol levels (19). In contrast to the literature (20), our comparison of the HDL-risk score, which reflects the ratio of total cholesterol to HDL-cholesterol, indicated that the mean values of HDLrisk scores of men (4.95±1.22, n=61) and women (4.96±1.55, n=29) were similar and there was no statistically significant difference between the groups (p<0.96). The absence of statistically significant differences may be due to the insufficient number of participants.…”

Section: Discussionmentioning

confidence: 95%

Characteristics of Coronary Artery Disease Patients Who Have a Polymorphism in the Cholesterol Ester Transfer Protein (CETP) Gene

Arıkan¹,

İşbir²,

Yılmaz³

et al. 2019

In Vivo

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Background/Aim: Cholesterol ester transfer protein (CETP) is responsible for the transformation of high density lipoprotein (HDL) to low density lipoprotein (LDL) and is a risk factor for atherosclerosis. Our study investigated the association of the rs5883 CETP gene polymorphism with HDL and LDL levels, in 45 coronary artery disease patients and 45 control patients. Materials and Methods: CETP gene polymorphism was detected using Real Time-Polymerase Chain Reaction (RT-PCR). Lipoprotein levels were measured using Quantimetrix system. Results: There were lack of associaition regarding CETP polymorphism in atherosclerosis and HDL and LDL levels (p>0.05) BMI was higher among coronary artery disease patients (CADP) compared to the control group (28.97±6.38, 26.52±4.39 respectively, p<0.03). Frequency of CADP (82.6 %, n=19) who were taking treatment was higher (17.4 %, n=4) (p<0.00). The frequencies of hypertension and type-2 diabetes were higher among CADP (p<0.00). Families of CADP have more CADP (p<0.02). Small HDL particle levels were higher in the control group (p<0.00). Conclusion: In Turkey, BMI, and frequencies of hypertension and type-2 diabetes were higher among CADP than among healthy controls. Furthermore, the genotypes of the rs5883 CETP gene polymorphism did not differ between CADP and healthy controls.

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Section: Discussionmentioning

confidence: 95%

Characteristics of Coronary Artery Disease Patients Who Have a Polymorphism in the Cholesterol Ester Transfer Protein (CETP) Gene

Arıkan¹,

İşbir²,

Yılmaz³

et al. 2019

In Vivo

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“…Looking at the individual components of the cardiometabolic risk factors, African people, for example, tend to have healthier (higher) high-density lipoprotein (HDL) and lower triglyceride levels, but are more likely to be hypertensive than whites [8], [9]. The prevalence of hypercholesterolemia is lower among Turkish and Moroccan adults living in the Netherlands [7], [10]. However, part of this advantage is off-set by their relatively low HDL cholesterol, resulting in an unfavourable total/HDL cholesterol ratio, particularly in the Turkish population [7].…”

Section: Introductionmentioning

confidence: 99%

“…The prevalence of hypercholesterolemia is lower among Turkish and Moroccan adults living in the Netherlands [7], [10]. However, part of this advantage is off-set by their relatively low HDL cholesterol, resulting in an unfavourable total/HDL cholesterol ratio, particularly in the Turkish population [7]. Paradoxically, the risk of developing DM2 and obesity is reported to be higher among all ethnic minority groups [6], [10]–[12].…”

Section: Introductionmentioning

confidence: 99%

Ethnic Differences in Cardiometabolic Risk Profile at Age 5–6 Years: The ABCD Study

et al. 2012

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BackgroundTo examine ethnic differences in cardiometabolic risk profile in early age, and explore whether such differences can be explained by differences in body mass index (BMI) or waist circumference (WC).MethodAnthropometric measurements, blood pressure and (in a subsample) fasting blood were collected during a health check of 2,509 children aged 5–6 years. Four ethnic groups were distinguished: Dutch (n = 2,008; blood n = 1,300), African descent (n = 199; blood n = 105), Turkish (n = 108; blood n = 57) and Moroccan (n = 194; blood n = 94). Ethnic differences in diastolic and systolic blood pressure (DBP/SBP), fasting glucose, low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triglyceride levels were determined and the explanatory role of BMI and WC was examined with regression analysis.ResultsAfter adjustment for confounders, African descent children showed higher DBP (β2.22 mmHg; 95%CI:1.09–3.36) and HDL levels (β:0.09 mmol/l; 95%CI:0.03–0.16) compared to Dutch children (reference group). Turkish children showed higher SBP (β:1.89 mmHg; 95%CI:0.25–3.54), DBP (β:2.62 mmHg; 95%CI:1.11–4.13), glucose (β:0.12 mmol/L; 95%CI:0.00–0.25) and triglyceride levels (β:0.13 mmol/L; 95%CI:0.02–0.25). Higher BMI values were found in all non–Dutch groups (differences ranged from 0.53–1.03 kg/m2) and higher WC in Turkish (β:1.68 cm; 95%CI:0.99–2.38) and Moroccan (β:1.65 cm; 95%CI:1.11–2.19) children. BMI and WC partly explained the higher SBP/DBP and triglyceride levels in Turkish children.ConclusionEthnic differences in cardiometabolic profile exist early in life and are partly explained by differences in BMI and WC. African children showed favourable HDL levels and Turkish children the most unfavourable overall profile, whereas their Moroccan peers have less increased cardiometabolic risk in spite of their high BMI and WC.

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“…Hypertension was less common in Turkish-Dutch and Moroccan-Dutch citizens of Amsterdam than among native Dutch citizens [19]. In these Turkish and Moroccan groups total cholesterol levels were low, as well as HDL cholesterol levels, resulting in an unfavourable total/HDL cholesterol ratio in particularly the Turkish ethnic group [20]. Diabetes was more common among Turkish-Dutch and Moroccan-Dutch than among native Dutch citizens of Amsterdam [21].…”

Section: Introductionmentioning

confidence: 99%

Ethnic differences in the association between cardiovascular risk factors and psychological distress in a population study in the Netherlands

et al. 2012

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BackgroundThere is growing body of evidence of an association between cardiovascular risk factors and depressive and anxiety symptoms. The purpose of this study was to investigate whether these associations are similar in ethnic minority groups.MethodsA random urban population sample, aged 18+, stratified by ethnicity (484 native Dutch subjects, 383 Turkish-Dutch subjects, and 316 Moroccan-Dutch subjects), in Amsterdam, the Netherlands, was interviewed with the Kessler Psychological Distress scale (K10) in combination with measurements of several cardiovascular risk factors. The association of psychological distress (defined as a K10 score above cut-off of 20) with cardiovascular risk factors (obesity, abdominal obesity, hypertension, hypercholesterolemia, low HDL cholesterol levels or diabetes), ethnicity and their interaction was analyzed using logistic regression analyses, stratified by gender and adjusted for age.ResultsCardiovascular risk factors were not significantly associated with psychological distress in any of the gender/ethnic groups, with the exception of a positive association of obesity and hypertension with psychological distress in native Dutch women and a negative association of hypertension and psychological distress in Turkish men. Interaction terms of cardiovascular risk factors and ethnicity were approaching significance only in the association of obesity with the K10 in women.ConclusionIn this cross-sectional multi-ethnic adult population sample the majority of the investigated cardiovascular risk factors were not associated with psychological distress. The association of obesity with psychological distress varies by gender and ethnicity. Our findings indicate that the prevention of obesity and psychological distress calls for an integrated approach in native Dutch women, but not necessarily in Turkish-Dutch and Moroccan-Dutch women, in whom these problems may be targeted separately.

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Ethnic differences in total and HDL cholesterol among Turkish, Moroccan and Dutch ethnic groups living in Amsterdam, the Netherlands

Cited by 20 publications

References 23 publications

Characteristics of Coronary Artery Disease Patients Who Have a Polymorphism in the Cholesterol Ester Transfer Protein (CETP) Gene

Characteristics of Coronary Artery Disease Patients Who Have a Polymorphism in the Cholesterol Ester Transfer Protein (CETP) Gene

Ethnic Differences in Cardiometabolic Risk Profile at Age 5–6 Years: The ABCD Study

Ethnic differences in the association between cardiovascular risk factors and psychological distress in a population study in the Netherlands

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