Ethnic Manifestations of Gene Polymorphisms of Vitamin D Receptor (VDR) in Adolescents of Western Kazakhstan Region

Аманжолкызы, А; Нургалиева, Р Е; Dosimov, A.Zh.; Stankevičius, Edgaras; Калдыбаева, А Т

doi:10.1016/j.jnma.2017.02.012

Cited by 6 publications

(7 citation statements)

References 18 publications

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“…Although, previous studies reported an association between VDR polymorphism and decreased serum 25(OH)D [28,29]. The current study was the rst study, conducted to detect the relation between serum 25(OH)D and PD, and the odds of PD in Asian adolescents with VDR [TaqI (rs731236)] polymorphism.…”

Section: The Taqi Genotypes and Its Relation To Serum 25(oh)d And Pdmentioning

confidence: 91%

Vitamin D and Vitamin D receptor polymorphism in Asian Adolescents with primary dysmenorrhea

Donayeva

Amanzholkyzy

Nurgaliyeva

et al. 2023

Preprint

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Background: The expression of vitamin D receptor in the normal endometrium and ovaries supports the role of vitamin D in local immunity and inflammatory cytokines regulation. Objective: This study aimed to detect the relation between serum 25(OH)D and primary dysmenorrhea. Methods: Two hundred and five (205) adolescents complaining of primary dysmenorrhea (study group) were compared with matched controls (210 controls), after informed consent following the Helsinki Declaration. After thorough evaluation, and pelvic ultrasound examination, blood samples were collected from the studied adolescents for measuring the serum 25(OH)D and for vitamin D receptor TaqI (rs731236) genotyping. Collected data were analyzed using the Pearson`s correlation to detect the relation between serum 25(OH)D and primary dysmenorrhea (primary outcome). The secondary outcome measures the odds of primary dysmenorrhea in Asian adolescents with TaqI (rs731236) polymorphism. Results: The serum 25(OH)D was significantly lower in the studied-dysmenorrhea group compared to controls (16.17 ± 7.36 versus 17.65 ± 6.36 ng/ml, respectively), (P=0.01). The correlation analysis showed a significant negative correlation between the serum 25(OH)D, and visual analogue scale of dysmenorrhea (r=-0.9003, P<0.0001). The studied-dysmenorrhea cases with T/t and t/t genotypes had significantly lower serum 25(OH)D (16.7 ± 8.05 and 14.4 ± 4.1 ng/ml, respectively) compared to controls (18.97 ± 6.7 and 21.4 ± 2.45 ng/ml, respectively), (P=0.02 and 0.004, respectively). The odds of primary dysmenorrhea were significantly higher in T/t and t/t genotypes (OR 1367.2, P<0.0001, and 106.2, P=0.001, respectively). Conclusion: The serum 25(OH)D was significantly lower in the studied-dysmenorrhea group compared to controls. The studied-dysmenorrhea cases with T/t and t/t TaqI genotypes had significantly lower serum 25(OH)D compared to controls. The odds of primary dysmenorrhea were significantly higher in T/t and t/t TaqI genotypes.

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Section: The Taqi Genotypes and Its Relation To Serum 25(oh)d And Pdmentioning

confidence: 91%

Vitamin D and Vitamin D receptor polymorphism in Asian Adolescents with primary dysmenorrhea

Donayeva

Amanzholkyzy

Nurgaliyeva

et al. 2023

Preprint

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“…Another reason is that summer temperatures in CA are so hot that people probably do not spend much time in the sun. Table 3 shows [6][7][8][9][10][11][12][13][14][15][16][17][18][19], mean serum 25(OH)D concentrations range from 4 to 23 ng/ml in CA and from 19 to 32 ng/ml in NE. (To convert ng/ml to nmol/L, divide by 2.5.)…”

Section: Data For Countries In Central Asia and Northern Europementioning

confidence: 99%

Comparing Vitamin D Status in Central Asia and Northern Europe

Grant

2020

CAJMHE

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Over the past two decades, the understanding of the roles of vitamin D has expanded to include many nonskeletal effects such as reduced risk of acute respiratory tract infections, autoimmune diseases, cancer, cardiovascular disease, diabetes mellitus, neurological diseases, and adverse pregnancy and birth outcomes. The role of vitamin D for optimal health is well known in Western developed countries but less so in Central Asian countries. This narrative review compares the status of vitamin D between Central Asian countries and Northern European countries. The analysis also summarizes the evidence for the beneficial effects of vitamin D and recommendations for Central Asian countries.

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“…Oznaczenia odmian polimorficznych genu VDR mogą stać się także czynnikiem predykcyjnym występowania reumatoidalnego zapalenia stawów (RZS) [55] i młodzieńczego zapalenia stawów [56]. Polimorfizmy genu VDR Apa1, Taq1, Bsm1 i Fok1 oznaczono u pacjentów z reumatoidalnym zapaleniem stawów (kobiety po menopauzie z osteoporozą i zdrowa grupa kontrolna) [55].…”

Section: Wpływ Polimorfizmów Genu Receptora Witaminy D (Vdr) Na Układunclassified

The impact of VDR gene polymorphisms on obesity, metabolic changes, bone mass disorders and neoplastic processes

Wysoczańska-Klaczyńska

Ślęzak

Hetman

et al. 2018

Pediatr Endocrino Diabetes Metab

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Ethnic Manifestations of Gene Polymorphisms of Vitamin D Receptor (VDR) in Adolescents of Western Kazakhstan Region

Cited by 6 publications

References 18 publications

Vitamin D and Vitamin D receptor polymorphism in Asian Adolescents with primary dysmenorrhea

Vitamin D and Vitamin D receptor polymorphism in Asian Adolescents with primary dysmenorrhea

Comparing Vitamin D Status in Central Asia and Northern Europe

The impact of VDR gene polymorphisms on obesity, metabolic changes, bone mass disorders and neoplastic processes

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