Ethnic skin disorders overview

Halder, Rebat M.; Nootheti, Pavan K.

doi:10.1067/mjd.2003.274

Cited by 208 publications

(166 citation statements)

References 26 publications

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“…In addition, they may explain the high prevalence of disorders of pigmentation in tan skin types in individuals of Asian, Hispanic/Latin American and African descent. 5,6,[30][31][32][33] These findings complete and confirm previous data obtained using skin colour classification based on ethnic origin or racial criteria. 34 They also emphasize that more pigmented melanocytes from intermediate and tan skin types may be targeted by UVR.…”

Section: Dna Damage In Melanocytessupporting

confidence: 80%

Variations in skin colour and the biological consequences of ultraviolet radiation exposure

2013

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SummaryHarmful consequences of sun exposure range from sunburn, photoageing and pigmentary disorders to skin cancer. The incidence and extent of these detrimental effects are largely due to the degree of constitutive pigmentation of the skin. The latter can be objectively classified according to the individual typology angle (°ITA) based on colorimetric parameters. The physiological relevance of the ITA colorimetric classification was assessed in 3500 women living in various geographical areas. Furthermore, in order to understand the relationship between constitutive pigmentation and ultraviolet radiation (UVR) sensitivity, we worked on ex vivo human skin samples of different colour exposed to increasing UVR doses. For each sample we defined the biologically efficient dose (BED), based on the induction of sunburn cells, and analysed UVR-induced DNA damage (cyclobutane thymine dimers, CPD). We found a significant correlation between ITA and BED. We also found a correlation between ITA and DNA damage. As the epidermal basal layer also hosts melanocytes and in order to analyse the relationship between skin colour and DNA damage occurring specifically within this cell type, we performed double staining for CPD and tyrosinase-related protein (TRP) 1, a key enzyme in melanin synthesis. We found that DNA damage within melanocytes depends on ITA. Taken together our results may explain the higher risk of lighter skin types developing skin cancers, including melanoma, as well as the development of pigmentary disorders in moderately pigmented skin. They show that skin classification based on ITA is physiologically relevant (as it correlates with constitutive pigmentation) and further support the concept of a more personalized approach to photoprotection that corresponds to a particular skin colour type's sensitivity to solar UVR.What's already known about this topic?• Sun exposure sensitivity is largely dependent on the degree of skin constitutive pigmentation.What does this study add?• The individual typology angle (ITA)-based skin colour classification correlates with constitutive pigmentation and is physiologically relevant in different geographical areas.• It may help identify differential responses to ultraviolet radiation (UVR) exposure that correspond to particular skin colour type's UVR sensitivities.• It supports the concept of personalized photoprotection.Harmful consequences of sun exposure range from sunburn, photoageing and pigmentary disorders to skin cancer. The incidence and extent of these detrimental effects is largely dependent on the degree of constitutive pigmentation of the skin.1-6 Human skin colour is determined by the total quantity of melanin, the proportion between the brown-black eumelanin

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Section: Dna Damage In Melanocytessupporting

confidence: 80%

Variations in skin colour and the biological consequences of ultraviolet radiation exposure

2013

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“…These hyperpigmented lentigenes include melasma, age spots or liverspots, and actinic damage (i.e., due to solar ultraviolet irradiation). [7][8][9][10] Thus the unique biochemical pathways in melanocytes responsible for melanogenesis provide rational mechanism-based means for developing both pharmacologic regulators of pigmentation and cytotoxic chemotherapeutic drugs for the treatment of melanoma.…”

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confidence: 99%

Inhibitory Effect of Miconazole on Melanogenesis

Mun

Lee

Jeong

et al. 2004

Biological & Pharmaceutical Bulletin

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Miconazole (MIC), a regional antifungal agent, has been used worldwide in the treatment of superficial mycosis. However, the effect of MIC on skin pigmentation is not known. In this study, we investigated the inhibitory effect of MIC on melanogenesis in B16 melanoma cells. Tyrosinase activity and melanin content were dose dependently decreased by MIC as compared with untreated cells. The level of tyrosinase protein expression was reduced with treatment MIC. A decrease in cell proliferation was observed in B16 cells treated with MIC 30 m mM, indicating that the MIC-induced depigmenting effect was caused by inhibition of melanin synthesis and not by destruction of B16 cells. Furthermore, MIC markedly suppressed a a-melanocyte stimulating hormone or forskolin-induced tyrosinase activity in B16 cells. Therefore the depigmenting effect of MIC might be due to the inhibition of tyrosinase activity and tyrosinase expression, which eventually slows melanin biosynthesis. These results indicate that MIC may be a useful inhibitor of melanogenesis in B16 cells and suggest that it may have beneficial effects in the treatment of hyperpigmentation disorders such as ephelis and melasma.

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“…Disturbance in melanin production can cause esthetic problems including skin hypopigmentary disorders, such as vitiligo, and hyperpigmentary disorders, such as melasma, freckles and postinflammatory hyperpigmentation, that may affect the quality of life of the patients (Halder & Nootheti, 2003). Environmental factors (e.g., UVR and drugs) and endogenous factors (e.g., hormone and age) can mediate the stimulation of melanin production through various signal pathways, which influence tyrosinase regulation.…”

Section: Fig 2 Melanin Synthesis Pathwaymentioning

confidence: 99%

Antioxidant Defense and UV-Induced Melanogenesis: Implications for Melanoma Prevention

Panich¹

2011

Current Management of Malignant Melanoma

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Ethnic skin disorders overview

Cited by 208 publications

References 26 publications

Variations in skin colour and the biological consequences of ultraviolet radiation exposure

Variations in skin colour and the biological consequences of ultraviolet radiation exposure

Inhibitory Effect of Miconazole on Melanogenesis

Antioxidant Defense and UV-Induced Melanogenesis: Implications for Melanoma Prevention

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