Ethnicity influences gut metabolites and microbiota of the tribes of Assam, India

Dehingia, Madhusmita; Sen, Supriyo; Bhaskar, Bhuwan; Joishy, Tulsi; Deka, Manab; Talukdar, Narayan Chandra; Khan, Mojibur R.

doi:10.1007/s11306-017-1206-y

Cited by 9 publications

(5 citation statements)

References 54 publications

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“…The influence of ethnicity on these profiles may be attributed to its genetic effect. Existing studies have also shown that racial/ethnic background strongly influences metabolism and microbes ( Human Microbiome Project Consortium, 2012 ; Dehingia et al, 2017 ). A study in the United Kingdom involving 416 pairs of twins also suggested that host genes determine gut microbiome and obesity phenotype ( Goodrich et al, 2014 ).…”

Section: Conclusion and Discussionmentioning

confidence: 99%

Diversity Scaling Analysis of Chinese Gut Microbiomes Across Ethnicities and Lifestyles

et al. 2021

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Diversity scaling (changes) of human gut microbiome is important because it measures the inter-individual heterogeneity of diversity and other important parameters of population-level diversity. Understanding the heterogeneity of microbial diversity can be used as a reference for the personalized medicine of microbiome-associated diseases. Similar to diversity per se, diversity scaling may also be influenced by host factors, especially lifestyles and ethnicities. Nevertheless, this important topic regarding Chinese populations has not been addressed, to our best knowledge. Here, we fill the gap by applying a recent extension to the classic species–area relationship (SAR), i.e., diversity–area relationship (DAR), to reanalyze a large dataset of Chinese gut microbiomes covering the seven biggest Chinese ethnic groups (covering > 95% Chinese) living rural and urban lifestyles. Four DAR profiles were constructed to investigate the diversity scaling, diversity overlap, potential maximal diversity, and the ratio of local to global diversity of Chinese gut microbiomes. We discovered the following: (i) The diversity scaling parameters (z) at various taxon levels are little affected by either ethnicity or lifestyles, as exhibited by less than 0.5% differences in pairwise comparisons. (ii) The maximal accrual diversity (potential diversity) exhibited difference in only about 5% of pairwise comparisons, and all of the differences occurred in ethnicity comparisons (i.e., lifestyles had no effects). (iii) Ethnicity seems to have stronger effects than lifestyles across all taxon levels, and this may reflect the reality that China has been experiencing rapid urbanization in the last few decades, while the ethnic-related genetic background may change relatively little during the same period.

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Section: Conclusion and Discussionmentioning

confidence: 99%

Diversity Scaling Analysis of Chinese Gut Microbiomes Across Ethnicities and Lifestyles

et al. 2021

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“…Extraction and derivatization of the metabolites were carried out using methods as described earlier with some modifications (Dehingia et al 2017). Briefly, 40 mg of lyophilized fecal sample was extracted with 1 ml of HPLC grade methanol (Merck, Mumbai, India) and kept in a shaker overnight at 1200 rpm.…”

Section: Extractionmentioning

confidence: 99%

Traditional rice beer depletes butyric acid-producing gut bacteria Faecalibacterium and Roseburia along with fecal butyrate levels in the ethnic groups of Northeast India

et al. 2020

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Ethnicity, geography, and dietary habits are known to have dominant roles in modulating the gut microbiota. Two major ethnic groups Ahom and Bodo in the north-east of India consume traditionally prepared rice beer which contains various microbes and substances that promote the growth of such microbes, known as prebiotics. This study aimed to understand the effect of traditionally prepared rice beer on gut microbiota. A total of 134 (67 from each group) volunteers including non-drinkers and drinkers from three locations were recruited. Fecal and blood samples were collected to study fecal bacterial and metabolite profiles and biochemical markers, respectively. Amplicon 16S rRNA gene sequencing (region V3-V4) by next-generation sequencing showed similar alpha and beta diversities in both the ethnic groups. However, with rice beer consumption the abundance of Firmicutes, Bacteroidetes, Fusobacteria phyla was higher in the drinkers (p < 0.05) of Ahom whereas only Firmicutes were higher in Bodo ethnic group. At the genus level, the bacterial abundance of Faecalibacterium and Roseburia were lower in the drinkers (p < 0.05) of both communities. Gas chromatography-mass spectrometry for the detection of fecal metabolites also revealed lower butyric acid in the feces of drinkers (p < 0.05). This study showed the effects of traditionally prepared rice beer on human gut microbiota and fecal metabolites. Further research is required to understand their effect on health.

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“…However, the relative abundance of bacterial phyla and/or colonisation by other microorganisms may vary greatly depending on all the factors that can influence the gut microenvironment parameters (e.g., pH, oxygen levels, temperature, availability of nutrients). These factors include dietary habits [ 18 ], age [ 19 ], pharmacological therapies (e.g., antibiotics) [ 20 , 21 , 22 ], host genetics [ 23 , 24 ], host geographic location [ 25 ], pathologies, lifestyle, and environmental stress [ 26 , 27 ], and account for high intra-individual time-related variations and for inter-individual diversification [ 28 , 29 , 30 ]. Compared to the microbiota which colonise other body sites (e.g., oral mucosa, vagina, and skin), gut microbiota is the major focus of researchers’ interest due to its higher clinical significance [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

“…Foods 2024, 13, 907 2 of 23 pharmacological therapies (e.g., antibiotics) [20][21][22], host genetics [23,24], host geographic location [25], pathologies, lifestyle, and environmental stress [26,27], and account for high intra-individual time-related variations and for inter-individual diversification [28][29][30]. Compared to the microbiota which colonise other body sites (e.g., oral mucosa, vagina, and skin), gut microbiota is the major focus of researchers' interest due to its higher clinical significance [31].…”

Section: Introductionmentioning

confidence: 99%

Milk Bioactive Compounds and Gut Microbiota Modulation: The Role of Whey Proteins and Milk Oligosaccharides

Gallo,

Arienzo,

Tomassetti

et al. 2024

Foods

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A strong correlation between the occurrence of various pathological conditions and intestinal dysbiosis is supported by a range of strong evidence. Vice versa, many pathologies have been shown, in turn, to be responsible for alterations in the gut microbiota, a condition that can worsen illness outcomes and response to therapies. For these reasons, great efforts have been made, and studies are still ongoing, to elucidate the mechanisms underlying gut microbiota alterations and to search for pharmacologic or other strategies that can effectively restore the gut microbiota. In this narrative review, we examined the most significant literature on the role of some milk bioactive compounds, such as milk oligosaccharides and whey proteins, in modulating the composition of the gut microbiota and the underlying mechanisms of action, with the aim of investigating the impact of the microbiota changes mediated by these milk bioactive molecules on human health, and their potential use as therapeutics to treat or adjuvate the treatment of gut dysbiosis and associated pathologies.

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Ethnicity influences gut metabolites and microbiota of the tribes of Assam, India

Cited by 9 publications

References 54 publications

Diversity Scaling Analysis of Chinese Gut Microbiomes Across Ethnicities and Lifestyles

Diversity Scaling Analysis of Chinese Gut Microbiomes Across Ethnicities and Lifestyles

Traditional rice beer depletes butyric acid-producing gut bacteria Faecalibacterium and Roseburia along with fecal butyrate levels in the ethnic groups of Northeast India

Milk Bioactive Compounds and Gut Microbiota Modulation: The Role of Whey Proteins and Milk Oligosaccharides

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