Ethnicity, obesity and the prevalence of impaired glucose tolerance and type 2 diabetes in PCOS: a systematic review and meta-regression

Kakoly, Nadira Sultana; Khomami, Mahnaz Bahri; Joham, Anju E.; Cooray, Shamil D.; Misso, Marie; Norman, Robert J.; Harrison, Cheryce L.; Ranasinha, Sanjeeva; Teede, Helena; Moran, Lisa J.

doi:10.1093/humupd/dmy007

Cited by 280 publications

(199 citation statements)

References 70 publications

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“…These results suggested that the association between H. pylori and diabetes was not a consequence of higher eradication failure in individuals with diabetes. It is suspected that there is an association between polycystic ovary syndrome (PCOS) and type 2 diabetes mellitus. It is also reported that there might be an association between PCOS and H. pylori infection.…”

Section: Discussionmentioning

confidence: 99%

Association between Helicobacter pylori infection, eradication and diabetes mellitus

Kato

Toda

Yamamoto‐Honda

et al. 2019

J of Diabetes Invest

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Aims/Introduction It is suspected that Helicobacter pylori is associated with extradigestive diseases including diabetes. So far, a number of studies have examined the association between H. pylori and diabetes, and the results were conflicting. The aim of the present study was to examine the association between H. pylori infection, eradication and diabetes. Materials and Methods The present cross‐sectional study was carried out using data from annual health checkups carried out at the Toranomon Hospital Health Management Center. The status of H. pylori infection, determined by serum antibodies and history of eradication, was categorized into three groups as “never,” “current” and “past.” The association between H. pylori infection and diabetes was examined using logistic regression. Results Of 21,634 participants, 6,530 (30.2%) had a current or past history of H. pylori infection, and 1,184 (5.5%) were identified as having diabetes. Multivariate adjusted odds ratios for diabetes compared with the “never” group were 1.36 (95% confidence interval 1.10–1.67) for the “current” group and 0.92 (95% confidence interval 0.79–1.07) for the “past” group. The association between H. pylori infection and diabetes was also observed among participants without a history of eradication. Conclusions We found that current H. pylori infection was associated with an increased risk of diabetes, and the increased risk was not observed among participants after eradication. The results were concordant with the hypothesis that H. pylori infection increases the risk of diabetes. Further studies are necessary to validate the present results.

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Section: Discussionmentioning

confidence: 99%

Association between Helicobacter pylori infection, eradication and diabetes mellitus

Kato

Toda

Yamamoto‐Honda

et al. 2019

J of Diabetes Invest

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“…Polycystic ovary syndrome (PCOS) is an endocrine disorder with a reported overall prevalence rate of 6% to 10% [1] based on the Rotterdam diagnostic criteria of two of three features, i.e., oligoor anovulation, hyperandrogenism (clinical or biochemical), and polycystic ovaries on ultrasound, after exclusion of other causes [2]. PCOS is associated with reproductive (hyperandrogenism, anovulation, infertility, and pregnancy complications) [3] and metabolic features (elevated prevalence of and risk factors for type 2 diabetes and cardiovascular disease) [4,5], along with psychological impact, such as increased risk of depression and anxiety [6] and impaired quality of life [7]. Insulin resistance is a key pathophysiological contributor to PCOS.…”

Section: Introductionmentioning

confidence: 99%

The Association between Dietary Intake, Asthma, and PCOS in Women from the Australian Longitudinal Study on Women’s Health

Grieger

Hodge

Mishra

et al. 2020

JCM

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Dietary intake potentially modifies the prevalence or severity of asthma. The prevalence of asthma is higher in women with polycystic ovary syndrome (PCOS); it is not known if diet confounds or modifies the association between asthma and PCOS. The aims of this study were: (i) To determine if the association of PCOS and asthma is independent of dietary pattern and (ii) to determine if dietary pattern modifies the association between PCOS and asthma. Women in this study were from the Australian Longitudinal Study on Women’s Health (ALSWH) cohort born between 1973 to 1978 and aged 18 to 23 years (n = 7382). Logistic regression was used to assess the association between PCOS and asthma, adjusting for the following: (i) Potential confounders identified a priori and (ii) dietary patterns (z-score) identified by principle component analysis. In the adjusted analysis, women with PCOS were more likely to have asthma than the women without PCOS (OR 1.35 and 95% CI, 1.02 and 1.78). This relationship was not altered by further adjustment for dietary patterns (non-core food, meats and takeaway, or Mediterranean-style pattern). In the interaction analysis, only the women consuming less than the median intake of non-core foods (i.e., lower intake of discretionary or unhealthy foods) and with PCOS were more likely to have asthma (OR 1.91 and 95% CI, 1.29 and 2.82). Dietary intake did not confound the relationship between PCOS and asthma. Other mechanistic pathways are likely responsible for the asthma and PCOS association, and further studies assessing factors such as oral contraceptive use and sex steroid hormones warrant investigation.

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“…По данным метаанализа 35 исследований, проведенного N.S. Kakoly et al (2018), у женщин с СПКЯ чаще отмечались НТГ, СД 2-го типа и метаболический синдром [11]. В датском популяционном исследовании 2017 г. частота развития СД 2-го типа была в 4 раза выше у женщин с СПКЯ по сравнению с группой контроля, кроме того, СД 2-го типа был диагностирован в более молодом возрасте у пациенток с установленным диагнозом СПКЯ [12].…”

Section: Discussionunclassified

Clinical features of polycystic ovary syndrome phenotypes in women with normogonadotropic anovulation in reproductive age

et al. 2019

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Hypothesis/aims of study. Polycystic ovary syndrome (PCOS) is a common disease, the frequency of which ranges from 8 to 13% in women of reproductive age. PCOS is a complex polygenic endocrine disorder with reproductive, metabolic, and psychological features. Currently, four PCOS phenotypes are identified that are associated with metabolic disorders, insulin resistance, impaired glucose tolerance (IGT), diabetes mellitus, and an increase in the number of risk factors for cardiovascular diseases. The aim of this study was to investigate the clinical features of PCOS phenotypes in women with normogonadotropic anovulation in reproductive age. Study design, materials, and methods. The study included 60 women of reproductive age from 24 to 37 years (mean age 28 ± 4 years) with PCOS and normogogonadotropic, normoprolactinemic anovulation. We studied the levels of anti-mullerian, follicle-stimulating, luteinizing hormone, prolactin, estradiol, and androgens from days 2 to 5 of the menstrual cycle. The serum progesterone level was studied by ELISA using test systems manufactured by Alkor Bio Ltd. (Russia) on days 20–23 of the menstrual cycle for three consecutive cycles. The average level of progesterone in the blood on days 20–23 of the menstrual cycle was 3.1 ± 1.5 nM. Echographic methods for diagnosing polycystic ovaries were used. All women included in the study underwent hysteroscopy on days 18–22 of the menstrual cycle, followed by a histological and immunohistochemical study of the endometrium. Results. In women with anovulatory PCOS phenotypes, phenotype A (classical) was detected in 32 (53.3%) women; phenotype B (anovulatory) in 18 (30%) women; phenotype D (non-androgenic) in 10 (16.7%) women with. In 32 (53.3%) patients, changes in carbohydrate metabolism (IGT) were found. Clinical and biochemical manifestations of androgen-dependent dermopathy (acne, oily seborrhea, and hirsutism) were significantly (p < 0.05) more often observed in PCOS patients with phenotypes A (84.4%) and B (88.9%) than in women with phenotype D (30%). In the majority (93.8%) of patients with IGT, the androgenic-anovulatory PCOS phenotypes were detected: phenotype A in 20 (62.5%) women and phenotype B in 10 (31.3%) women. Phenotype D (non-androgenic) was present only in two women with PCOS and IGT. As a result of complex histological and immunohistochemical studies of endometrial biopsy specimens, chronic endometritis was detected in 44 (73.3%) examined women with PCOS and simple glandular endometrial hyperplasia was diagnosed in 13 (21.7%) PCOS patients. The incidence of chronic endometritis and simple glandular endometrial hyperplasia in women with normogonadotropic anovulation and PCOS directly depended (r = 0.35; p < 0.05) on disorders of carbohydrate metabolism and was detected more often in patients with PCOS and IGT. Conclusion. The differential approach to the examination of patients with various PCOS phenotypes allows personalizing the therapy of this disease and determining the complex of preventive measures to improve the quality of life of women of reproductive age.

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Ethnicity, obesity and the prevalence of impaired glucose tolerance and type 2 diabetes in PCOS: a systematic review and meta-regression

Abstract: CRD42017056524.

Cited by 280 publications

References 70 publications

Association between Helicobacter pylori infection, eradication and diabetes mellitus

Association between Helicobacter pylori infection, eradication and diabetes mellitus

The Association between Dietary Intake, Asthma, and PCOS in Women from the Australian Longitudinal Study on Women’s Health

Clinical features of polycystic ovary syndrome phenotypes in women with normogonadotropic anovulation in reproductive age

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