Ethnicity/Race and Age-Specific Variations of Serum AMH in Women—A Review

Kotlyar, Alexander; Seifer, David B.

doi:10.3389/fendo.2020.593216

Cited by 40 publications

(32 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As reported previously [ 31 ], ethnic origin can affect the serum circulating hormonal levels such as LH, T and free testosterone in men or AMH in women [ 32 ]. This can be explained by recent data from a large series of monozygotic and dizygotic male twins [ 33 ] and a genome-wide association study [ 34 ].…”

Section: Discussionmentioning

confidence: 90%

Contribution of serum anti-Müllerian hormone in the management of azoospermia and the prediction of testicular sperm retrieval outcomes: a study of 155 adult men

Benderradji

Prasivoravong

Marcelli

et al. 2021

Basic Clin. Androl.

View full text Add to dashboard Cite

Background Testicular sperm extraction (TESE) is the method of choice for recovering spermatozoa in patients with azoospermia. However, the lack of reliable biomarkers makes it impossible to predict sperm retrieval outcomes at TESE. To date, little attention has been given to anti-Müllerian hormone (AMH) serum levels in adult men with altered spermatogenesis. In this study we aimed to investigate whether serum concentrations of AMH and the AMH to total testosterone ratio (AMH/T) might be predictive factors for sperm retrieval outcomes during TESE in a cohort of 155 adult Caucasian men with azoospermia. Results AMH serum levels were significantly lower in nonobstructive azoospermia (NOA) that was unexplained, cryptorchidism-related, cytotoxic and genetic (medians [pmol/l] = 30.1; 21.8; 26.7; 7.3; and p = 0.02; 0.001; 0.04; <0.0001, respectively]) compared with obstructive azoospermia (OA) (median = 44.8 pmol/l). Lowest values were observed in cases of genetic NOA (p < 0.0001, compared with unexplained NOA) and especially in individuals with non-mosaic Klinefelter syndrome (median = 2.3 pmol/l, p <0.0001). Medians of AMH/T values were significantly lower in genetic NOA compared to unexplained, cryptorchidism-related NOA as well as OA. Only serum concentrations of AMH differed significantly between positive and negative groups in men with non-mosaic Klinefelter syndrome. The optimal cut-off of serum AMH was set at 2.5 pmol/l. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of this cut-off to predict negative outcomes of SR were 100 %, 76.9 %, 66.6 %, 100 and 84.2 %, respectively. Conclusions Serum AMH levels, but not AMH/T values, are a good marker for Sertoli and germ cell population dysfunction in adult Caucasian men with non-mosaic Klinefelter syndrome and could help us to predict negative outcomes of SR at TESE with 100 % sensitivity when serum levels of AMH are below 2.5 pmol/l.

show abstract

Section: Discussionmentioning

confidence: 90%

Contribution of serum anti-Müllerian hormone in the management of azoospermia and the prediction of testicular sperm retrieval outcomes: a study of 155 adult men

Benderradji

Prasivoravong

Marcelli

et al. 2021

Basic Clin. Androl.

View full text Add to dashboard Cite

show abstract

“…Lastly, our population is fairly homogenous with respect to race and ethnicity and examination of AMH levels by race/ ethnicity has shown variability in AMH levels among women of different racial and ethnic backgrounds. [43][44][45] Although we would not expect the use of OCs or having a TL procedure to influence AMH levels differently by race or ethnicity, further examination in more diverse populations is important.…”

Section: Discussionmentioning

confidence: 99%

Association of oral contraceptives and tubal ligation with antimüllerian hormone

et al. 2021

View full text Add to dashboard Cite

Objective: Oral contraceptives (OCs) and tubal ligation are commonly used methods of contraception that may impact ovarian function. Few studies have examined the association of these factors with antimu ¨llerian hormone (AMH), a marker of ovarian aging.Methods: We examined the association of OC use and tubal ligation with AMH in the Nurses' Health Study II prospective cohort among a subset of 1,420 premenopausal participants who provided a blood sample in 1996-1999. History of OC use and tubal ligation were reported in 1989 and updated every 2 years until blood collection. We utilized generalized linear models to assess whether mean AMH levels varied by duration of and age at first use of OCs and history, age, and type of tubal ligation.Results: In multivariable models adjusted for smoking, reproductive events, and other lifestyle factors, we observed a significant, inverse association between duration of OC use and mean AMH levels (P for trend ¼ 0.036). Compared to women without a tubal ligation, AMH levels were significantly lower when the procedure included a clip, ring, or band (1.04 ng/ml vs 1.72 ng/ml, P < 0.01). AMH levels were not associated with age at first use of OCs or age at tubal ligation.Conclusions: Our analysis found an association between duration of OC use and certain types of tubal ligation with mean AMH levels. Further research is warranted to confirm the long-term association of these widely used contraceptive methods with AMH.

show abstract

“…AMH is closely related to female age. Several studies [32][33][34] measured the low AMH values for certain ages: 3.0 ng/mL for 25 years old, 2.5 ng/mL for 30 years old, 1.5 ng/mL for 35 years old, 1 ng/mL for 40 years old, and 0.5 ng/mL for 45 years old. Since AMH is positively correlated with the number of highquality embryos, for patients with low AMH values, the clinicians should be optimistic about the assessment of their existing ovarian function and the possible number of high-quality embryos in IVF/ICSI.…”

Section: Discussionmentioning

confidence: 99%

Investigating the correlation between AMH and the number of high-quality embryos from IVF/ICSI in 30-44 year-old infertile women

chen

et al. 2022

Preprint

View full text Add to dashboard Cite

Background To explore the effect of anti-Müllerian hormone (AMH) on embryonic development by studying the relationship between serum AMH concentration and the high-quality embryo number during the first cycle of in vitro fertilization (IVF) /intracytoplasmic sperm injection (ICSI) in 30-44 year-old infertile women.Methods A retrospective cohort study of 335 cycles was conducted. The study population was the patients who received the first IVF/ICSI cycle at the Reproductive Medicine Center of * * * * * * from January 2019 to December 2020. The basic characteristics, clinical medication and cycle outcome of patients were collected, and the correlation between AMH and the number of high-quality embryos was analyzed.Results After adjusted for confounding factors (female age, AFC and COH protocol), sensitivity analysis showed that high-quality embryo number in high AMH group increases by 2.2 units for each additional unit of AMH (≥8.5 ng/mL) (95%CI: (0.8, 3.7), P=0.003). The two-piecewise regression model identified the inflection point as AMH=7.1 ng/mL, and the effect size, 95% CI and P value on both sides of the inflection point were 0.5(0.3, 0.7), <0.001 and 0.1(-0.1, 0.2), 0.518, respectively. The results of stratified analysis and interaction test showed that the relationship between AMH and the high-quality embryo number was stable among different subgroups (P>0.05).Conclusion When AMH<7.1ng/mL, there is a positive correlation between AMH and the number of high-quality embryos in this study population. Therefore, the effect of age-related ovarian reserve biomarker AMH on reproductive prognosis can provide reference for ART clinical treatment.Plain English summary Diminished ovarian reserve (DOR) refers to a decrease in the number and/or quality of oocytes in the ovary, accompanied by a decrease in anti-Müllerian hormone (AMH) levels, a decrease in antral follicle count (AFC) and an increase in follicle stimulating hormone (FSH) levels. The most common clinical symptoms are shortened menstrual cycle and decreased menstrual flow. Most patients go to the hospital after long-term unsuccessful attempts to conceive, so delays in diagnosis are common. Assisted reproductive technology (ART) is the main means of achieving pregnancy in patients with DOR. With the improvement and adjustment of the ovulation induction program and the innovation of laboratory technology, the clinical pregnancy rate of ART has increased. However, DOR patients have poor ovarian response to gonadotropins (Gn), manifested as less follicle development, low blood estrogen levels, high Gn dosage, lower-than-expected oocyte retrieval, high cycle cancellation rate, and low clinical pregnancy rate in ovarian stimulation cycles. Therefore, this type of patients is a difficult point in the field of assisted reproduction. In the present study, elevated AMH was associated with an increased number of high-quality embryos in individuals aged 30-44 years at high risk for DOR. AMH can assess the potential reproductive prognosis of such patients and provide valuable data for clinical treatment of such patients.

show abstract

Ethnicity/Race and Age-Specific Variations of Serum AMH in Women—A Review

Cited by 40 publications

References 56 publications

Contribution of serum anti-Müllerian hormone in the management of azoospermia and the prediction of testicular sperm retrieval outcomes: a study of 155 adult men

Contribution of serum anti-Müllerian hormone in the management of azoospermia and the prediction of testicular sperm retrieval outcomes: a study of 155 adult men

Association of oral contraceptives and tubal ligation with antimüllerian hormone

Investigating the correlation between AMH and the number of high-quality embryos from IVF/ICSI in 30-44 year-old infertile women

Contact Info

Product

Resources

About