Ethnicity-stratified analysis of the association between P53 rs1042522 polymorphism and women HPV infection: A meta-analysis

Si, Dan; Yao, Yan-Ping; Xu, Chen; Qiu, Jun

doi:10.1016/j.micpath.2021.105099

Cited by 13 publications

(6 citation statements)

References 23 publications

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“…Our results do not fully align with those reported in previous literature, a discrepancy we consider to be reasonable. [11][12][13][14][15][16][17] Contradictory findings are not uncommon in genetic research due to the influence of race, region, and other factors. Genetic polymorphisms vary significantly across different countries and regions, impacted by the distinct racial backgrounds present.…”

Section: Discussionmentioning

confidence: 99%

Genetic polymorphism of IL-17 influences susceptibility to recurrent pregnancy loss in a Chinese population

Li,

Uskenbayeva,

Fang

et al. 2024

Medicine

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The current research aims to investigate the relationship between Interleukin-17 (IL-17) polymorphism and the risk of recurrent pregnancy loss (RPL) within a Chinese population. Totally, 120 patients with RPL were selected and enrolled as the experiment group. Additionally, 210 healthy individuals undergoing routine physical examinations during the same period served as the control group. The IL-17 gene polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism method. The IL-17 rs2275913 polymorphism exhibited 3 genotypes: GG, GA, and AA. Significant associations were observed with the AA genotype and A allele (all P < .05), indicating women with the AA genotype were 2.06 times more likely to experience RPL compared to those with the GG genotype. Similarly, women carrying the A allele faced a 1.63 times higher risk of RPL than those with the G allele. Regarding the IL-17 rs763780 polymorphism, which also presented 3 genotypes (TT, TC, CC), significant associations were noted for the CC genotype and C allele (all P < .05). Women with the CC genotype had a 1.84 times greater risk of suffering from RPL compared to those with the TT genotype, and those with the C allele were 1.51 times more likely to experience RPL than those with the T allele. The IL-17 rs2275913 and rs763780 polymorphisms contribute an increased risk to RPL in the Chinese population. Further studies, with larger sample sizes and more rigorous designs, are necessary to validate or replicate our current results.

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Section: Discussionmentioning

confidence: 99%

Genetic polymorphism of IL-17 influences susceptibility to recurrent pregnancy loss in a Chinese population

Li,

Uskenbayeva,

Fang

et al. 2024

Medicine

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“…All methods applying the present meta-analysis were based on published literatures. [11][12][13][14][15][16][17][18][19][20][21][22][23][24] 2.4. Statistical analysis SPSS17, STATA11 software, t test, χ2 test statistic tools were applied in our investigation, as reported by previous literatures.…”

Section: Meta-analysis Processmentioning

confidence: 99%

MMP-3 gene regulates the carcinogenesis and metabolic process of ovarian cancer, evidence from a Chinese population: Observational study and meta-analysis

Wang,

Yao,

2023

Medicine

Self Cite

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The current investigation aims to explore the relationship between matrix metalloproteinase-3 (MMP-3) gene polymorphism and ovarian cancer (OC) risk. Two hundred forty pathologically confirmed OC patients and 390 healthy controls participated in the present investigation. Polymerase chain reaction-restriction fragment length polymorphism was applied to investigate the present polymorphism. At the same time, the meta-analysis was also performed to comprehensively explore the relationship. Three genotypes (5A/5A, 5A/6A, and 6A/6A) were observed for MMP-3 gene polymorphism. 6A/6A genotype and 6A allele displayed significant increase in OC patients (all P < .05). Meta-analysis found that no significant results (all P > .05). In conclusion, our results indicate that MMP-3 gene polymorphism contributes increased risk to OC for southern Chinese population. And meta-analysis indicates that MMP-3 gene polymorphism contributes no risk to OC in other populations.

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“…However, these analyzes were mainly performed by microarray with validation by qRT-PCR with potential biases linked to the methodology such as the comparison between tumoral sample and adjacent normal appearance tissue and by the preselection of some miRNAs as proven in other context ( 113 ). In addition, most studies are from China raising the issue on variations of HPV genotypes according to ethnicity thus on ncRNA expression ( 114 ). Moreover, the relatively small number of studies with limited sample size focusing on early CC stages especially concerning miRNAs expression in biofluids of patients with CC limit their potential clinical utility.…”

Section: Perspectivesmentioning

confidence: 99%

Value of non-coding RNAs to assess lymph node status in cervical cancer

et al. 2023

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Cervical cancer (CC) is the fourth cancer in women and is the leading cause of cancer death in 42 countries. Lymph node metastasis is a determinant prognostic factor, as underlined in the latest FIGO classification. However, assessment of lymph node status remains difficult, despite the progress of imaging such as PET-CT and MRI. In the specific setting of CC, all data underlined the need for new biomarkers easily available to assess lymph node status. Previous studies have underlined the potential value of ncRNA expression in gynecological cancers. In this review, we aimed to evaluate the contribution of ncRNAs in tissue and biofluid samples to determine lymph node status in CC with potential impact on both surgical and adjuvant therapies. In tissue samples, our analysis found that there are arguments to support the role of ncRNAs in physiopathology, differential diagnosis from normal tissue, preinvasive and invasive tumors. In biofluids, despite small studies especially concerning miRNAs expression, promising data opens up new avenue to establish a non-invasive signature for lymph node status as well as a tool to predict response to neo- and adjuvant therapies, thus improving management algorithm of patients with CC.

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Ethnicity-stratified analysis of the association between P53 rs1042522 polymorphism and women HPV infection: A meta-analysis

Cited by 13 publications

References 23 publications

Genetic polymorphism of IL-17 influences susceptibility to recurrent pregnancy loss in a Chinese population

Genetic polymorphism of IL-17 influences susceptibility to recurrent pregnancy loss in a Chinese population

MMP-3 gene regulates the carcinogenesis and metabolic process of ovarian cancer, evidence from a Chinese population: Observational study and meta-analysis

Value of non-coding RNAs to assess lymph node status in cervical cancer

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