Ethnobotanical, phytochemical, toxicology and anti-diabetic potential of Senna occidentalis (L.) link; A review

Nde, Adeline Lum; Chukwuma, Chika I.; Erukainure, Ochuko L.; Chukwuma, Maria S.; Matsabisa, Motlalepula G.

doi:10.1016/j.jep.2021.114663

Cited by 12 publications

(10 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similarly, C. papaya, Guiera senegalensis, M. indica, Musa sapientum, P. guineense were reported by at least two or all of the states as plants used for treating hepatitis. Medicinal plants cited for treatment of hepatitis in the present study including Phyllanthus amarus Senna occidentalis and Garcinia kola have also been reportedly used to treat hepatitis and liver diseases in the southern part of Nigeria [12] , [13] , [14] . Likewise, Acacia nilotica Guiera senegalesis and Leptadenia hastate among others cited herein for treatment of hepatitis are also used to treat the same viral disease in Burkina Faso ( Table 7 ) with pharmacological study validating the anti-hepatitis C activity of A. nilotica [15] .…”

Section: Discussionmentioning

confidence: 99%

“…Asthma, bronchitis, cough, mental disorders, fever, flu, febrifuge, skin disease, tuberculosis and hypertension China, Brazil, India. Malaria, fever and hepatitis in Nigeria [ 14 , 15 ] LD 50 is higher than 5 g/kg [85] . Seed extract induced subacute toxicity including hepatotoxicity in mice [109] .…”

Section: Discussionmentioning

confidence: 99%

“…Seed extract induced subacute toxicity including hepatotoxicity in mice [109] . Raw pod and seed caused poisoning in children in India affecting the hepatic, skeletal, brain system and resulting in fatal coma [14] Hepatitis, meningitis, COVID-19, yellow fever, poliomyelitis Cassia tora Leaves and seeds are used as a liver tonic, antimicrobial, skin diseases, fever, and cardiotonic in Ayurveda [ 110 , 111 ] Dried seed extract inhibited replication SARS-CoV replication [112] The ethanol seed extracts did not induce subchronic toxicity effect on biochemical parameters of rat [113] Hepatitis, meningitis, yellow fever Chasmanthera dependens Hochst. Used to treat infectious diseases, pain, malaria, epilepsy, convulsions and fractures in Nigeria and West Africa [114] Aqueous and methanol extract of leaf, root and stem did not exhibit any chronic toxicity on rats [115] Poliomyelitis, meningitis Chenopodium ambrosioides L. Used to treat fever in Morocco and as treatment for lung and fungal infection in West Africa [ 116 , 117 ] Induced antiviral activity against HSV-1 [118] High doses of 12.31–31.89 g/kg caused lung congestion and necrosis of the kidney tubules [117] Poliomyelitis, Meningitis Cordia africana Lam.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Traditional medicinal plants used for treating emerging and re-emerging viral diseases in northern Nigeria

Abubakar

Kankara

Malami

et al. 2022

European Journal of Integrative Medicine

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Traditional medicinal plants used for treating emerging and re-emerging viral diseases in northern Nigeria

Abubakar

Kankara

Malami

et al. 2022

European Journal of Integrative Medicine

View full text Add to dashboard Cite

“…Varios de sus componentes químicos han sido identificados, entre ellos, glucósidos de antraquinona, aceites grasos, glucósidos flavonoide galactomanano, polisacáridos y varios taninos. Aunque se considera autóctona de Brasil, es una planta naturalizada en Nigeria donde está muy extendida y crece profusamente (Lum Nde et al, 2022). Se emplea en medicina tradicional en la región tropical del mundo, destacándose su asociación a las funciones diurética y antifebril.…”

Section: Cecropia Pachystachya Tréculunclassified

“…Se emplea en medicina tradicional en la región tropical del mundo, destacándose su asociación a las funciones diurética y antifebril. También se ha informado sobre su posible actividad antinflamatoria y antihepatotóxica (Lum Nde et al, 2022). En cuanto a su actividad biológica, se ha informado su actividad antiplasmodial y ha sido descrito como antibacteriano en diferentes trabajos de investigación (Chomnawang et al, 2009).…”

Section: Cecropia Pachystachya Tréculunclassified

Desarrollo de aditivos antimicrobianos basados en nanopartículas metálicas obtenidas por síntesis verde para su aplicación en recubrimientos

Roque

Bellotti

Viera

View full text Add to dashboard Cite

La preocupación creciente por el control de la colonización y crecimiento de hongos y bacterias en los interiores edilicios ha impulsado distintas líneas investigativas que comprenden el desarrollo de nuevas pinturas y recubrimientos con propiedades antimicrobianas que eviten el asentamiento de los microorganismos. Estas formulaciones contienen uno o más aditivos antimicrobianos llamados biocidas. Entre los productos investigados se destacan las nanopartículas de ciertos materiales metálicos (plata, cobre, selenio y oro) que han mostrado algún grado de bioactividad. Las nanopartículas se caracterizan por contar con propiedades dependientes del tamaño y la forma, a su vez, éstas son afectadas por el método y las condiciones de síntesis. Existe un creciente interés en desarrollar procesos de obtención de nanopartículas que sean amigables con el ambiente, es decir que eviten el uso de productos químicos cuestionados desde el punto de vista de su toxicidad. Esta tendencia enmarcada en la denominada química verde tiene como objetivos principales reducir los desechos, minimizar el uso de productos no seguros y beneficiar el uso de solventes y reactivos amigables con el ambiente. La síntesis verde de nanopartículas basada en el uso de extractos vegetales acuosos resulta promisoria por ser accesible, efectiva, segura, de bajo costo, no contaminante y por ofrecer vastas posibilidades. El objetivo de esta investigación fue desarrollar nuevos aditivos antimicrobianos de base nanotecnológica obtenidos por síntesis verde, aplicables en forma eficiente en la formulación de pinturas antimicrobianas que prevengan el biodeterioro. Para lograr este objetivo se trabajó en primer lugar en la obtención, caracterización y selección de las nanopartículas con mayor actividad tanto antibacteriana como antifúngica. En una siguiente etapa, se formularon y prepararon pinturas con los aditivos antimicrobianos desarrollados reemplazando los biocidas tradicionales que se usan en las pinturas comerciales fuertemente cuestionados desde el punto de vista de la salud y el impacto ambiental.

show abstract

Novel Natural Candidates for Replacing Synthetic Additives in Nutraceutical and Pharmaceutical Areas: Two Senna Species (S. alata (L.) Roxb. and S. occidentalis (L.) Link)

Yagi,

Cetiz,

Zengin

et al. 2024

Food Science & Nutrition

View full text Add to dashboard Cite

Senna alata (L.) Roxb. and Senna occidentalis (L.) Link (family Fabaceae) are commonly used in different systems of traditional medicine to treat ailments. The present study was designed to determine the phytoconstituents, antioxidant, enzyme inhibition, and antimicrobial activities of the methanolic extract from the leaves of these two Senna species. A total of 75 phenolic compounds belonging to dihydroxybenzoic acids, dihydroxycinnamic acids, flavonoid C‐glycosides, flavonoid O‐glycosides, flavonoid aglycones, anthraquinone glycosides, and anthraquinone aglycones were identified. Flavonoid C‐glycosides were only found in S. occidentalis while sennosides A, B, and C were only detected in S. alata. In line with its higher total phenolic and flavonoids contents, S. alata exerted significantly (p < 0.05) higher antiradical (2,2‐diphenyl‐1‐picrylhydrazy (DPPH) = 58.36 mg trolox equivalent (TE)/g; 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid (ABTS) = 118.86 mg TE/g), ions reducing (cupric reducing antioxidant capacity (CUPRAC) = 93.85 mg TE/g; ferric reducing antioxidant power (FRAP) = 50.42 mg TE/g), and total antioxidant (1.39 mmol TE/g) activities than S. occidentalis. S. alata revealed significantly (p < 0.05) higher inhibitory effect against butyrylcholinesterase (1.67 mg galantamine equivalent (GALAE)/g), tyrosinase (45.07 mg KAE/g) 45.07 mg kojic acid equivalent (KAE)/g), α‐glucosidase (0.73 mmol acarbose equivalent (ACAE)/g), and α‐amylase (2.95 mmol ACAE/g) enzymes. Both species showed high antibacterial and antifungal activities with remarkable antifungal activity exerted by S. alata against Trichoderma viride (minimum inhibition concentration (MIC) 1 mg/mL), similar to that of Ketoconazole. The study utilized molecular docking, molecular mechanics Poisson–Boltzmann surface area (MM/PBSA) free energy calculations, and molecular dynamics simulations to evaluate the binding interactions between anthraquinone glycosides and various bacterial enzymes, including targets from Escherichia coli and Staphylococcus aureus. The findings suggest that compounds like sennoside A, sennoside B, and chrysophanol exhibit strong binding affinities, stable interactions, and potential as antimicrobial inhibitors, especially against vital bacterial proteins such as MurE and 30S ribosome S3. In conclusion, our findings underscore the biopharmaceutical potential of these two Senna species, suggesting their significance as sources of bioactive agents for health‐related applications.

show abstract

Ethnobotanical, phytochemical, toxicology and anti-diabetic potential of Senna occidentalis (L.) link; A review

Cited by 12 publications

References 101 publications

Traditional medicinal plants used for treating emerging and re-emerging viral diseases in northern Nigeria

Traditional medicinal plants used for treating emerging and re-emerging viral diseases in northern Nigeria

Desarrollo de aditivos antimicrobianos basados en nanopartículas metálicas obtenidas por síntesis verde para su aplicación en recubrimientos

Novel Natural Candidates for Replacing Synthetic Additives in Nutraceutical and Pharmaceutical Areas: Two Senna Species (S. alata (L.) Roxb. and S. occidentalis (L.) Link)

Contact Info

Product

Resources

About