Ethnobotanical study of antimalarial plants in Shinile District, Somali Region, Ethiopia, and in vivo evaluation of selected ones against Plasmodium berghei

Mesfin, Akalu; Giday, Mirutse; Animut, Abebe; Teklehaymanot, Tilahun

doi:10.1016/j.jep.2011.11.006

Cited by 73 publications

(53 citation statements)

References 28 publications

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“…A water extract of the fruits of Tamarindus indica showed the highest level of parasitemia suppression (81.09%) at a dose of 650 mg/kg. For the in vivo tests, all of the plant extracts were given to mice orally (29). The use of lipid nanocarriers such as liposomes and nanocapsules to improve the delivery of antimalarial compounds has also been established.…”

Section: Discussionmentioning

confidence: 99%

Enhanced Antimalarial Activity by a Novel Artemether-Lumefantrine Lipid Emulsion for Parenteral Administration

Zhao

et al. 2014

Antimicrob Agents Chemother

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dArtemether and lumefantrine (also known as benflumetol) are difficult to formulate for parenteral administration because of their low aqueous solubility. Cremophor EL as an emulsion excipient has been shown to cause serious side effects. This study reports a method of preparation and the therapeutic efficacies of novel lipid emulsion (LE) delivery systems with artemether, lumefantrine, or artemether in combination with lumefantrine, for parenteral administration. Their physical and chemical stabilities were also evaluated. Furthermore, the in vivo antimalarial activities of the lipid emulsions developed were tested in Plasmodium berghei-infected mice. Artemether, lumefantrine, or artemether in combination with lumefantrine was encapsulated in an oil phase, and the in vivo performance was assessed by comparison with artesunate for injection. It was found that the lumefantrine lipid emulsion (LUM-LE) and artemether-lumefantrine lipid emulsion (ARM-LUM-LE-3) (1:6) began to decrease the parasitemia levels after only 3 days, and the parasitemia inhibition was 90% at doses of 0.32 and 0.27 mg/kg, respectively, with immediate antimalarial effects greater than those of the positive-control group and constant antimalarial effects over 30 days. LUM-LE and ARM-LUM-LE-3 demonstrated the best performance in terms of chemical and physical stabilities and antiplasmodial efficacy, with a mean particle size of 150 nm, and they have many favorable properties for parenteral administration, such as biocompatibility, physical stability, and ease of preparation. Malaria is one of the most significant causes of morbidity and death worldwide. Every year, nearly one million deaths result from malaria infection, with about 85% occurring among children under 5 years of age. Indeed, one patient dies from malaria every 36 s (1).Artemisinin and its derivatives are the most important antimalarial drugs; the chemical structures of the four artemisinin compounds and lumefantrine (also known as benflumetol) are presented in Fig. 1. Artemisinin is an effective antimalarial drug isolated from the Chinese herbal medicine Artemisia annua L. It has a special sesquiterpene lactone with a peroxy group. In malaria parasites, artemisinin can be activated by intraparasitic heme iron, which catalyzes cleavage of the endoperoxide (2). Due to its unique structure and antimalarial mechanism, artemisinin has excellent antimalarial activity with low toxicity; therefore, artemisinin-based combination therapy (ACT) is recommended as the first-line strategy to treat malaria (3). After the introduction of ACT interventions, morbidity and mortality rates associated with malaria were decreased in several parts of the world (4). However, antimalarial resistance would probably be increased after longterm application of artemisinin alone. WHO reformed the malaria treatment policy in February 2004, proposing to stop the use of single antimalarial drugs (e.g., artemisinin and quinine) and promoting the use of ACTs. Recently, combination therapies such as artemether in co...

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Section: Discussionmentioning

confidence: 99%

Enhanced Antimalarial Activity by a Novel Artemether-Lumefantrine Lipid Emulsion for Parenteral Administration

Zhao

et al. 2014

Antimicrob Agents Chemother

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“…These properties may be attributable to the presence in the plant of various phytochemicals with, among others, antibacterial, antifungal, antiviral, antiparasitic, anti-inflammatory, and antioxidant properties [191,192,193,194]. T. indica leaves contain various polyphenols and flavonoids with wound healing-stimulating properties [195,196], the seeds contain the hemicellulose xyloglucan which can protect the skin from the damaging effects of ultraviolet radiation [197], and the seed oil contains abundant amounts of linoleic acid and oleic acid [194].…”

Section: Tamarindus Indica Lmentioning

confidence: 99%

“A thing of beauty is a joy forever”. Plants and plant-based preparations for facial care in Suriname

Mans¹,

Grant²

2017

Clin Med Invest

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People have probably used plant-based substances to improve their appearance since the existence of mankind. The first documented use of cosmetics dates back to 3,000 BC from ancient Egypt, but it is safe to say that this custom has been (and still is) an integral part of daily life in all civilizations. The initial use of plantderived makeup -sometimes supplemented with paints and dyes -has come full circle and is back with the contemporary trend of using beauty products that are mainly derived from plant sources. The Republic of Suriname (South America) is renowned for its extensive ethnopharmacological knowledge and unique plant biodiversity that provides ample raw material that can be processed into cosmetics and cosmeceuticals. This paper gives some historical highlights on the use of makeup throughout the world with the emphasis on naturally-derived products; focuses on the herbal cosmetics industry in Suriname; extensively addresses the scientific rationale for incorporating extracts from plants in cosmetics and cosmeceuticals in the country; and concludes with the conditions to establish a beauty products industry in Suriname.

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“…This is a remarkable step given that DRC accounts for about 15% of global malaria deaths (Hay et al, 2010). Mesfin et al (2012) documented medicinal plants that are traditionally used for the treatment of malaria in Shinile District, eastern Ethiopia. They also evaluated some of the plants for activity against P. berghei.…”

Section: Democratic Republic Of Congomentioning

confidence: 99%

“…According to their results, species of Aloe L., A. indica and Tamarindus indica L were the most commonly reported antimalarial plants. In mice, ethanol and water leaf extracts of Aloe species at a dose of 650 mg/kg suppressed parasitaemia by 73.94% and 58.10%, respectively (Mesfin et al, 2012). An ethanol extract of A. indica leaves at a dose of 650 mg/kg produced 54.79% parasitaemia suppression but its water extract gave significantly lower parasite suppression (21.47%) at a similar dose.…”

Section: Democratic Republic Of Congomentioning

confidence: 99%

Plants as antimalarial agents in Sub-Saharan Africa

Chinsembu

2015

Acta Tropica

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Ethnobotanical study of antimalarial plants in Shinile District, Somali Region, Ethiopia, and in vivo evaluation of selected ones against Plasmodium berghei

Cited by 73 publications

References 28 publications

Enhanced Antimalarial Activity by a Novel Artemether-Lumefantrine Lipid Emulsion for Parenteral Administration

Enhanced Antimalarial Activity by a Novel Artemether-Lumefantrine Lipid Emulsion for Parenteral Administration

“A thing of beauty is a joy forever”. Plants and plant-based preparations for facial care in Suriname

Plants as antimalarial agents in Sub-Saharan Africa

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