Ethnobotanical study of medicinal plants used for the treatment of malaria in the plateau region, Togo

Agbodeka, Kodjovi; Gbekley, Holaly E.; Karou, Simplice Damintoti; Anani, Kokou; Agbonon, Amégnona; Tchacondo, Tchadjobo; Batawila, Komlan; Simporé, Jacques; Gbéassor, Messanvi

doi:10.4103/0974-8490.178646

Cited by 25 publications

(18 citation statements)

References 41 publications

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“…Malaria, liver disease [12], tuberculosis [30], malaria, [86,87], fever [18] Antibacterial activity (Methanol root extract) [88], antitumour activity and immunomodulatory effects (Aqueous leaf extract) [89] in vitro (Cup plate agar diffusion method) [88], in vitro (Cell viability assay, caspase assay, microarray analysis) [89] The aqueous and ethanol leaf extracts were reported to be cytotoxic on human oral squamous cell carcinoma SCC25 cell lines [90] The aqueous leaf extract was reported to disrupt cell division and to induce mitotic spindle disturbance in Allium cepa [91] The methanol leaf extract was reported to be cytotoxic against LLC-MK2 cell lines [92] The aqueous leaf extract was reported to be non-toxic in Sprague Dawley rats at a 2000 mg/kg dose [93] No morphological alterations were reported in Sprague Dawley rats treated with a 28-day repeated oral dose of 2000 mg/kg [94] Aqueous and ethanol leaf extracts were reported to be nontoxic at doses of up to 5000 mg/kg [95] The methanol leaf, root, and stem bark extracts were reported to be nontoxic against MRC- 5 Croton megalocarpus Del.…”

Section: Diversity Of Medicinal Plants Identified In the Study Area Amentioning

confidence: 99%

Medicinal plants used in managing diseases of the respiratory system among the Luo community: an appraisal of Kisumu East Sub-County, Kenya

et al. 2020

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Background: Poor access to healthcare in rural communities causes many people to seek herbalists who use medicinal plants for the treatment of various disease conditions. Most knowledge of traditional herbal medicine makes use of indigenous remedies which are often undocumented and are at risk of being lost. The preservation of this knowledge may facilitate scientific inquiry into promising new therapeutic molecules. Methods: Semi-structured questionnaires were used to collect the sociodemographic information of 30 herbalists in Kisumu East Sub County. The local names of medicinal plants used in managing illnesses of the respiratory system, their habit, active parts, indications, methods of preparation, routes of administration, scientific identity, and conservation status were also recorded. Other reported traditional uses, pharmacological activities, and toxicological data were identified via a literature search. Results: Most herbalists were female (86.7%), aged between 61 and 70 years (43.3%) with no formal education (56.7%), and had 21-30 years of practice (30%). 44 plant species, belonging to 43 genera and 28 families were identified. Leguminosae and Rutaceae plant families were predominant, leaves were frequently used (33%), and trees were the most common habit (44.4%). Most plants were collected in the wild (79.2%), preparation was mainly by decoction (68.8%), and the administration was mainly orally. The main indication was cough and 79.5% of all documented plant species had previously been reported to have a pharmacological activity relevant to the mitigation of respiratory illnesses. Toxicological data was available for 84.1% of the plant species identified. Conclusions: The predominant use of roots, root barks, and root tubers by herbalists in Kisumu East Sub County threatens to negatively impact the ecological survival of some plant species. The preservation of herbalists' knowledge of medicinal plants in the study area is a pressing concern considering their advanced age and little formal education. There is a need to conserve some of the medicinal plants documented in this study. The medicinal claims made by herbalists also warrant scientific scrutiny.

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Section: Diversity Of Medicinal Plants Identified In the Study Area Amentioning

confidence: 99%

Medicinal plants used in managing diseases of the respiratory system among the Luo community: an appraisal of Kisumu East Sub-County, Kenya

et al. 2020

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“…Engl. Malaria, fever [54], swollen testicles and abdominal pains [38], pneumonia [30] Ethanolic crude root extract had antifungal and antibacterial activity [55] Warburgia salutaris (G.Bertol) Chiov Chest complaints, cough, fever, pneumonia [15] Yellow fever [56], common cold, malaria [57], and Aspergillosis [58] Acetone extract showed fungicidal activity against Fusarium species [59], antimycobacterial activity [60,61] Carica papaya L. Malaria, liver disease [22], tuberculosis [34], malaria [62,63], fever [14] Methanolic extract of roots showed antibacterial activity [64], the presence of alkaloids, tannins, saponins, glycosides and phenols were detected [64] Terminalia brownie Fresen…”

Section: Graymentioning

confidence: 99%

Medicinal Plants Used In Managing Diseases Of The Respiratory System Among The Luo Community: An Appraisal Of Kisumu East Sub-County, Kenya

Mailu

Nguta

Mbaria

et al. 2020

Preprint

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Background Respiratory diseases cause many deaths in children under 5 years of age particularly in Africa. The efficacy of current treatment differs among respiratory diseases and adverse effects may depend on dosage, duration of treatment, and the type of drug. Poor access to healthcare in rural areas makes many people in such communities to rely on traditional medicine. Most knowledge on traditional medicine makes use of indigenous remedies which are often undocumented and are at risk of being lost. Ethnobotanical data on medicinal plants used in managing diseases of the respiratory system may facilitate the search for new pharmaceutical agents. Methods Semi-structured questionnaires were used to collect information from 30 traditional medicine practitioners in Kisumu East Sub County. The sociodemographic characteristics of the informants, the local names of the plants used, their habit, active parts, indications, and methods of preparation, as well as routes of administration, scientific identity, and conservation status were recorded. A literature search was conducted via PubMed, Google Scholar, and Research Gate to identify other reported activities of the plants. Results Most practitioners were female (86.7%), were aged between 61 and 70 years (43.3%), had no formal education (56.7%), and had 21-30 years of practice (30%). A total of 45 plant species, belonging to 43 genera and 28 families were identified. Leguminosae and Rutaceae were the most dominant plant families, leaves were the most frequently used (33%), and trees were the most common habit (44.4%). Cough was the most common indication, decoction was the most common method of administration (68.8%), most preparations were taken orally, and most plants were collected in the wild (79.2%). Literature search established that at least 42/45 plant species had pharmacological activities. Conclusions Many plant species reported in this study have similar traditional uses in other communities. One plant; Keetia gueinzii (Sond.) Bridson was reported for the first time in the management of asthma, pneumonia, and cough. Documentation and preservation of ethno medicinal knowledge in the study area is of prime concern as most practitioners are advanced in age with little formal education. Plans to conserve some of the medicinal plants documented here should be initiated. Scientific validation of the traditional claims made is also needed.

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“…It is a plant used in traditional medicine in treating of a lot of diseases. The plant is used in the treatment of yellow fever, malaria and stomach disorders (Mann et al, 2003;Chakraborty et al, 2012;Agbodeka et al, 2016). In some parts of South America, it is used as diuretic.…”

Section: Introductionmentioning

confidence: 99%

Toxicological Study of Hydroalcohol Leaf Extract of Acanthospermum hispidum (Asteraceae)

Diallo

Salem

Badjabaissi

et al. 2020

American Journal of Pharmacology and Toxicology

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Acanthospermum hispidum is a widely plant used in African traditional medicine. This study aims to assess cardiotoxicity and subchronic (28-days) oral toxicity of hydroalcohol leaf extract of A. hispidum. The sub-chronic toxicity was evaluated after administering daily oral doses of 500 and 1000 mg/kg body wt., for 28 days to the rats, biochemical and haematological assessments as well as body and relative organ weights of the rats were carried out. The results of the study have shown that blood sodium was significantly (p < 0.05) lower in the group treated with 500 and 1000 mg/kg of A. hispidum extract and the blood platelet was significantly high. The weekly body and organ weight of the rats showed no significant differences between the control and the rats treated with the extract except for the testis where there was a significant decrease (p < 0.05) in rats that received 1000 mg/kg, i.e., 1.16±0.2 g against 0.78±0.22 g for the control. A discreet seminiferous tubular atrophy and fibrosis of the tube wall were observed at this dose. The hydroalcoholic extract of A. hispidum at 0.1; 1; 10 and 100 mg/ml on toad heart and isolated atria of guinea pigs have caused a significant increase in cardiac amplitude (positive inotropic) and a significant decrease (p < 0.0001) in frequency (negative chronotropism). Our results suggest that the hydroalcohol extract of A. hispidum is relatively toxic to the testis and caution must be taken at high doses especially for the heart.

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Ethnobotanical study of medicinal plants used for the treatment of malaria in the plateau region, Togo

Cited by 25 publications

References 41 publications

Medicinal plants used in managing diseases of the respiratory system among the Luo community: an appraisal of Kisumu East Sub-County, Kenya

Medicinal plants used in managing diseases of the respiratory system among the Luo community: an appraisal of Kisumu East Sub-County, Kenya

Medicinal Plants Used In Managing Diseases Of The Respiratory System Among The Luo Community: An Appraisal Of Kisumu East Sub-County, Kenya

Toxicological Study of Hydroalcohol Leaf Extract of Acanthospermum hispidum (Asteraceae)

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