Synthetic drugs show major side effects, as well as the fact that they have been discovered to be extremely harmful to human assistance, many synthetic medications claimed to be used for treatment are of the least interest today. Therefore, herbal medicines have acquired prominence in recent decades. This review's primary objective is to give a complete overview of three distinct species of the Genus Atalantia mainly Atalantia monophylla (Roxb) DC, Atalantia racemaosa Wight, Atalantia wightii Tanaka. The Genus Atalantia belongs to Rutaceae family and there are 22 accepted species of which three species are selected because these are available in Western Ghat region of Maharashtra, these species have ethnopharmacological significance and many of their facets are still unexplored. The Atalantia genus is utilized in conventional medicine to treat a diverse array of ailments like fever, rheumatic pains, cough, allergy, swelling, and as a blood purifier, etc. The current work is a comprehensive analysis of the published literature on phytochemical and pharmacological reports of the above species of Atalantia genus in an effort to deliver comprehensive information and suggest future research avenues. Out of these three species, Atalantia monophylla has received the most research attention but the remaining two species are not much explored. The aim of this review is to discuss the potential application of these three species as herbal medicine. The plant characteristics, ethnobotanical uses, phytochemistry, and pharmacological activities are summarized as a guide for phytochemical and pharmacological investigations.